Changes in bone mineral density after bariatric surgery in patients of different ages or patients with different postoperative periods: a systematic review and meta-analysis

Ou, Xiaodan; Chen, Mingguang; Xu, Leiting; Lin, Wei; Huang, Hui‐Bin; Chen, Gang; Wen, Junping

doi:10.1186/s40001-022-00774-0

Cited by 7 publications

(5 citation statements)

References 76 publications

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“…However, the lack of aBMD variation at the lumbar spine and the reduction in bone turnover with time may suggest a limited effect of age. Our observational results are only generalizable to the same type of surgery-i.e., SG-as variations in aBMD between different surgical approaches, in particular RYGB, have been demonstrated [16,37]. Moreover, despite the relatively long time covered by our longitudinal study, we cannot exclude the possibility that other skeletal changes occur over a longer period, and this should be considered in future studies.…”

Section: Limitations and Strengthsmentioning

confidence: 88%

“…Using a similar surgical procedure, Hofso et al [16] reported a similar aBMD loss around 5% at femoral neck and 7.8% at total hip, while at lumbar spine and whole body, minor variations occurred after 12 months. A recently published meta-analysis including 22 studies [37] noted an obvious aBMD loss at femoral neck and none at lumbar spine. This conclusion should be considered with caution, as some of the included studies reported an aBMD decrease at lumbar spine [21].…”

Section: Abmdmentioning

confidence: 99%

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Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study

Maïmoun,

Aouinti,

Puech

et al. 2023

Nutrients

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Bariatric surgery induces bone loss, but the exact mechanisms by which this process occurs are not fully known. The aims of this 2-year longitudinal study were to (i) investigate the changes in areal bone mineral density (aBMD) and bone turnover markers following sleeve gastrectomy (SG) and (ii) determine the parameters associated with the aBMD variations. Bone turnover markers, sclerostin, periostin and semaphorin 4D were assessed before and 1, 12 and 24 months after SG, and aBMD was determined by DXA at baseline and after 12 and 24 months in 83 patients with obesity. Bone turnover increased from 1 month, peaked at 12 months and remained elevated at 24 months. Periostin and sclerostin presented only modest increases at 1 month, whereas semaphorin 4D showed increases only at 12 and 24 months. A significant aBMD decrease was observed only at total hip regions at 12 and 24 months. This demineralisation was mainly related to body weight loss. In summary, reduced aBMD was observed after SG in the hip region (mechanical-loading bone sites) due to an increase in bone turnover in favour of bone resorption. Periostin, sclerostin and semaphorin 4D levels varied after SG, showing different time lags, but contrary to weight loss, these biological parameters did not seem to be directly implicated in the skeletal deterioration.

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Section: Limitations and Strengthsmentioning

confidence: 88%

Section: Abmdmentioning

confidence: 99%

Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study

Maïmoun,

Aouinti,

Puech

et al. 2023

Nutrients

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“…A recent meta-analysis comprising 22 studies evaluating BS patients found that the decrease in BMD was larger in the femoral neck than in the lumbar spine [ 15 ]. Additionally, a time-dependent loss of BMD was observed, with larger decreases found in longer follow-up periods.…”

Section: Introductionmentioning

confidence: 99%

Effects of whole-body vibration on body composition, microbiota, cardiometabolic markers, physical fitness, and quality of life after bariatric surgery: protocol for a randomized controlled trial

Gómez-Bruton,

Irún,

Matute-Llorente

et al. 2024

Trials

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Background Morbid obesity is a complex chronic condition characterized by a body mass index of 40 kg/m2 or higher. The incidence of the condition is on the rise in developed countries, and bariatric surgery has been proposed as a potential solution to address this trend. Nonetheless, bariatric surgery may also result in adverse effects, including a reduction in bone mineral density (BMD) and muscle mass, as well as an increased risk of fractures. The present study aims to elucidate the effects of bariatric surgery and whole-body vibration (WBV) training on body composition, microbiota, physical fitness, quality of life, and cardiometabolic markers. Methods Twenty-eight participants (14 females), aged 18 to 50 years, will undergo sleeve gastrectomy surgery. They will be randomly allocated into a control group or a WBV training group. The WBV group will train three times per week with increasing intensities and duration ranging from 30 to 45 min over the 4-month training period. Measurements of body composition (dual-energy X-ray absorptiometry and peripheral quantitative computed tomography), physical fitness (muscular strength, agility, cardiorespiratory fitness, and balance), gait biomechanics, cardiometabolic markers, gut microbiota, quality of life, and physical activity levels will be collected at four different time points: (1) prior to the surgery, (2) 45 days post-surgery, (3) 6 months post-surgery, and (4) 18 months post-surgery. Discussion Both groups are expected to experience improvements in most of the aforementioned variables. Nonetheless, we expect the WBV group to show larger improvements proving that the training is effective and safe. Trial registration Clinicaltrials.gov NCT05695599. Registered on January 25, 2023.

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“…Throughout different life stages, BMD values vary, with rapid growth occurring during childhood and adolescence, culminating in peak BMD in early adulthood ( Deng et al, 2021 ). However, as individuals age, hormone levels, such as estrogen and testosterone, decline, leading to a subsequent reduction in BMD ( Ou et al, 2022 ). This loss of bone mass can increase the likelihood of developing conditions like periodontitis and arthritis while raising the risk of fractures ( Hartley et al, 2022 ; Yu and Wang, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between gut microbiota and bone mineral density: a Mendelian randomization study

Wang,

Zhang,

Tang

et al. 2023

Front. Microbiol.

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BackgroundThe gut microbiota has emerged as an intriguing and potentially influential factor in regulating bone health. However, the causal effect of the gut microbiota on bone mineral density (BMD) appears to differ throughout various life stages.MethodsWe conducted a Mendelian randomization (MR) analysis to investigate the potential causal relationship between gut microbiota and BMD in five distinct age groups: 0–15, 15–30, 30–45, 45–60, and 60 years and older. The analysis employed three different methods, namely MR-Egger, weighted median, and Inverse-variance weighting, to ensure the robustness of our findings, a series of sensitivity analyses were also conducted, such as horizontal pleiotropy tests, heterogeneity tests, and leave-one-out sensitivity tests.ResultsIn the age group of 0–15 years, Eubacterium_fissicatena_group and Eubacterium_hallii_group were identified as risk factors for BMD. During the 15–30 age group, Phascolarctobacterium, Roseburia, and Ruminococcaceae_UCG_003 were found to be protective factors for BMD. In the 30–45 age group, Lachnospira genus demonstrated a protective effect on BMD, while Barnesiella and Lactococcus were identified as risk factors for BMD. Moving on to the 45–60 age group, Eubacterium_ventriosum_group, Lachnospiraceae_UCG_004, and Subdoligranulum were observed to be protective factors for BMD, while Eubacterium_coprostanoligenes_group, Fusicatenibacter, and Lactococcus were associated with an increased risk of BMD. In individuals aged 60 years and older, Fusicatenibacter and Ruminococcaceae_UCG_002 were also noted as risk factors for BMD. Conversely, Eubacterium_ruminantium_group, Ruminococcus_gauvreauii_group, Alistipes, and Coprococcus_3 were found to be protective factors for BMD, whereas Barnesiella and Sellimonas were identified as risk factors for BMD.ConclusionA robust causal relationship between gut microbiota and bone mineral density (BMD) exists throughout all stages of life, with Firmicutes phylum being the primary group associated with BMD across age groups. Gut microbiota linked with BMD primarily belong to the Firmicutes phylum across age groups. The diversity of gut microbiota phyla associated with BMD depicts relatively stable patterns during the ages of 0–45 years. However, for individuals aged 45 years and above, there is an observed increase in the number of gut microbiota species linked with BMD, and by the age of 60 years, a trend toward an increase in the Bacteroidetes phylum categories is proposed.

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Changes in bone mineral density after bariatric surgery in patients of different ages or patients with different postoperative periods: a systematic review and meta-analysis

Cited by 7 publications

References 76 publications

Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study

Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study

Effects of whole-body vibration on body composition, microbiota, cardiometabolic markers, physical fitness, and quality of life after bariatric surgery: protocol for a randomized controlled trial

The causal relationship between gut microbiota and bone mineral density: a Mendelian randomization study

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