Changes in Bone Resorption During the Menstrual Cycle

Chiu, Kit Mui; Ju, Julia A.; Mayes, Darrel M.; Bacchetti, Peter; Weitz, Steve; Arnaud, Claude D.

doi:10.1359/jbmr.1999.14.4.609

Cited by 61 publications

(38 citation statements)

References 39 publications

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“…As previously reported in other studies of bone formation markers including P1NP (23)(24)(25), we found that serum automated total P1NP concentrations decreased from age 30 to 35 years and then remained stable up to 50 years in healthy premenopausal women. The higher values in younger women probably reflect the fact that skeletal maturity has not yet been achieved, especially at the cortical sites, a time of increased bone turnover.…”

Section: Discussionsupporting

confidence: 89%

Evaluation of a Fully Automated Serum Assay for Total N-Terminal Propeptide of Type I Collagen in Postmenopausal Osteoporosis

2008

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Section: Discussionsupporting

confidence: 89%

Evaluation of a Fully Automated Serum Assay for Total N-Terminal Propeptide of Type I Collagen in Postmenopausal Osteoporosis

2008

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“…Much of the variability is likely to be related to cyclic fluctuations of female sex hormones. Biochemical markers of bone resorption are clearly influenced by fluctuations in these hormones [10,23,48]. In one study, PYD varied as much as 50% from 3 days after ovulation to day 3 of the follicular period of the same menstrual cycle [48].…”

Section: Discussionmentioning

confidence: 99%

Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins

Zwart

Hargens

Lee

et al. 2007

Bone

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Supine weight-bearing exercise within lower body negative pressure (LBNP) alleviates some of the skeletal deconditioning induced by simulated weightlessness in men. We examined the potential beneficial effect in women. Because dietary acid load affected the degree of bone resorption in men during bed rest, we also investigated this variable in women. Subjects were 7 pairs of female identical twins assigned at random to 2 groups, sedentary bed rest (control) or bed rest with supine treadmill exercise within LBNP. Dietary intake was controlled and monitored. Urinary calcium and markers of bone resorption were measured before bed rest (BR) and on BR days 5/6, 12/13, 19/20, and 26/27. Bone mineral content was assessed by dual-energy X-ray absorptiometry before and after bed rest. Data were analyzed by repeated measures two-way analysis of variance. Pearson correlation coefficients were used to define the relationships between diet and markers of bone metabolism, and to estimate heritability of markers. During bed rest, all markers of bone resorption and urinary calcium and phosphorus increased (P < 0.001); parathyroid hormone (P = 0.06), bone-specific alkaline phosphatase (P = 0.06), and 1,25-dihydroxyvitamin D (P = 0.09) tended to decrease. LBNP exercise tended to mitigate bone density loss. The ratio of dietary animal protein to potassium was positively correlated with urinary calcium excretion for all weeks of bed rest in the control group, but only during weeks 1 and 3 for the exercise group. Pre-bed rest data suggested that many markers of bone metabolism have strong genetic determinants. Treadmill exercise within LBNP had less of a protective effect on bone resorption during bed rest in women than previously-published results had Sources of support: This study was funded by NASA through grant NAG 9-1425 and by NIH through grant GCRC M01-RR00827 to UCSD.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. shown for its effect in men, but the same trends were observed for both sexes. Dietary acid load of these female subjects was significantly correlated with calcium excretion but not with other bone resorption markers. NIH Public Access

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“…The effect of the menstrual cycle on markers of bone turnover is small [175,176]. Zitterman et al [177] have recently reported a signi®cant menstrual rhythm in deoxypyridinoline and pyridinoline excretion with an amplitude of 33% and 32% respectively and a nadir in the early luteal phase.…”

Section: Menstrualmentioning

confidence: 99%