Changes in brain cyclic AMP levels during chronic ethanol treatment and withdrawal in the rat

Shen, Anna L.; Jacobyansky, Andrew; Pathman, Donald E.; Thurman, Ronald G.

doi:10.1016/0014-2999(83)90613-1

Cited by 12 publications

(1 citation statement)

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“…At the end o f 3 weeks, all rats were given normal diet for 24 h (withdrawal state [15]), and they exhibited withdrawal signs within this period. At 24 h after chronic ethanol treatment, when ethanol had been eliminated and overt withdrawal symptoms had subsided, the rats were decapitated and the brains were rapidly removed and stored at -8 0°C until they were assayed.…”

Section: Chronic Ethanol Treatmentmentioning

confidence: 99%

Effects of Chronic Ethanol Treatment on Inositol 1,4,5-Trisphosphate Receptors and Inositol 1,3,4,5-Tetrakisphosphate Receptors in Rat Brain

et al. 1996

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In this study, the effects of chronic ethanol treatment on inositol 1,4,5-tris-phosphate (IP3) and inositol 1,3,4,5-tetrakisphosphate (IP4) specific binding in rat brain was investigated. In the cerebellum, chronic, but not acute, ethanol treatment caused a decrease in the number of IP3 receptors. The effect of chronic ethanol treatment on IP3 and IP3 receptor mRNA levels was also studied in order to determine the mechanisms responsible for the decrease in IP3 receptor binding. Chronic ethanol treatment did not change IP3 levels, indicating that the decrease of IP3 receptors is not caused by the alteration of IP3 levels. Also IP3 receptor mRNA levels had no change after chronic ethanol treatment. These findings suggest that the decrease in IP3 receptors in the cerebellum could be caused by either a decrease in the translation of IP3 receptor mRNA or an increase in proteolysis of IP3 receptors. In contrast, chronic ethanol treatment had no effect on the B_max or K_d of IP4 specific binding in the cerebellum. It is speculated that a change at the level of the IP3 receptor in the cerebellum may be associated with the development of adaptation and tolerance to chronic ethanol exposure.

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Section: Chronic Ethanol Treatmentmentioning

confidence: 99%