Changes in brain functional connectivity and cognition related to white matter lesion burden in hypertensive patients from SPRINT

Shah, Chintan; Srinivasan, Dhivya; Erus, Güray; Schmitt, J. Eric; Agarwal, Adhish; Cho, Monique E.; Lerner, Alan J.; Haley, William E.; Tamura, Manjula Kurella; Davatzikos, Christos; Bryan, R. Nick; Fan, Yong; Nasrallah, Ilya M.

doi:10.1007/s00234-020-02614-6

Cited by 11 publications

(11 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This idea is reinforced by the fact that (i) resistance training improves hippocampal integrity in older adults with mild cognitive impairment [59,60] and (ii) the hippocampus mediates the relationship between higher levels of physical fitness (i.e., cardiorespiratory fitness) and spatial memory performance [56,58]. In this context, it could be speculated that the neurobiological processes leading to a higher HGS might be protective against the frequently reported hypertension-related worsening of brain integrity (e.g., faster decline in hippocampal volume and more global brain matter atrophy) and cognitive performance (e.g., more pronounced decline in executive function and memory) [61][62][63][64]. However, to the best of our knowledge, there is a lack of cross-sectional and longitudinal studies that assess and analyze the relationship between measures of HGS, brain structure, and cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension

Herold

Zhang

et al. 2021

Brain Sciences

View full text Add to dashboard Cite

Objective: There is growing evidence that in adults, higher levels of handgrip strength (HGS) are linked to better cognitive performance. However, the relationship between HGS and cognitive performance has not been sufficiently investigated in special cohorts, such as individuals with hypertension who have an intrinsically higher risk of cognitive decline. Thus, the purpose of this study was to examine the relationship between HGS and cognitive performance in adults with hypertension using data from the Global Ageing and Adult Health Survey (SAGE). Methods: A total of 4486 Chinese adults with hypertension from the SAGE were included in this study. Absolute handgrip strength (aHGS in kilograms) was measured using a handheld electronic dynamometer, and cognitive performance was assessed in the domains of short-term memory, delayed memory, and language ability. Multiple linear regression models were fitted to examine the association between relative handgrip strength (rHGS; aHGS divided by body mass index) and measures of cognitive performance. Results: Overall, higher levels of rHGS were associated with higher scores in short-term memory (β = 0.20) and language (β = 0.63) compared with the lowest tertiles of rHGS. In male participants, higher HGS was associated with higher scores in short-term memory (β = 0.31), language (β = 0.64), and delayed memory (β = 0.22). There were no associations between rHGS and cognitive performance measures in females. Conclusion: We observed that a higher level of rHGS was associated with better cognitive performance among hypertensive male individuals. Further studies are needed to investigate the neurobiological mechanisms, including sex-specific differences driving the relationship between measures of HGS and cognitive performance in individuals with hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension

Herold

Zhang

et al. 2021

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…Rs-fMRI data were preprocessed in standard fashion, as reported previously. 7 These included removal of the first 6 volumes, section-time correction, motion correction, nuisance variable regression, spatial smoothing (6-mm full width at half maximum), bandpass filtering (0.01-0.1 Hz), and registration via the T1weighted scan into Montreal Neurological Institute template space, followed by resampling to a 4-mm isotropic resolution. Scans were excluded if any framewise motion exceeded 3.5 mm and if the mean relative displacement was 0.3 mm.…”

Section: Functional Image Processingmentioning

confidence: 99%

“…15 The 20 identified components can be found in previously published work. 7 Canonical networks were identified from these by visual inspection. Subject-level independent components were extracted using group information-guided independent component analysis 16,17 and were used to calculate z score maps for each network for each study participant.…”

Section: Functional Image Processingmentioning

confidence: 99%

“…Subject-level independent components were extracted using group information-guided independent component analysis 16,17 and were used to calculate z score maps for each network for each study participant. 7 A mean connectivity score (MCS) was calculated for each network in each participant as the participant's average withinnetwork FC within a 3D mask of the network generated from the group-level independent component analysis. 18 This represents a metric of overall network coherence with greater scores reflecting more integrated dynamics within the network 18 and in this cohort, it was found to be related to baseline volume of WMH for networks of interest as described below.…”

Section: Functional Image Processingmentioning

confidence: 99%

“…In a study of SPRINT MR imaging participants at baseline, the burden of WMH was inversely related to FC of the default mode network (DMN) and of the auditory-salience-language network (ASLN). 7 To further determine the impact of hypertension treatment on brain health, we assessed longitudinal changes in brain functional connectivity (DFC) to determine whether intensive treatment results in less decline in FC and how DFC relates to changes in brain structure.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial

Shah

Srinivasan

Erus

et al. 2023

AJNR Am J Neuroradiol

Self Cite

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:The Systolic Blood Pressure Intervention (SPRINT) randomized trial demonstrated that intensive blood pressure management resulted in slower progression of cerebral white matter hyperintensities, compared with standard therapy. We assessed longitudinal changes in brain functional connectivity to determine whether intensive treatment results in less decline in functional connectivity and how changes in brain functional connectivity relate to changes in brain structure. MATERIALS AND METHODS:Five hundred forty-eight participants completed longitudinal brain MR imaging, including resting-state fMRI, during a median follow-up of 3.84 years. Functional brain networks were identified using independent component analysis, and a mean connectivity score was calculated for each network. Longitudinal changes in mean connectivity score were compared between treatment groups using a 2-sample t test, followed by a voxelwise t test. In the full cohort, adjusted linear regression analysis was performed between changes in the mean connectivity score and changes in structural MR imaging metrics.RESULTS: Four hundred six participants had longitudinal imaging that passed quality control. The auditory-salience-language network demonstrated a significantly larger decline in the mean connectivity score in the standard treatment group relative to the intensive treatment group (P ¼ .014), with regions of significant difference between treatment groups in the cingulate and right temporal/insular regions. There was no treatment group difference in other networks. Longitudinal changes in mean connectivity score of the default mode network but not the auditory-salience-language network demonstrated a significant correlation with longitudinal changes in white matter hyperintensities (P ¼ .013). CONCLUSIONS:Intensive treatment was associated with preservation of functional connectivity of the auditory-salience-language network, while mean network connectivity in other networks was not significantly different between intensive and standard therapy. A longitudinal increase in the white matter hyperintensity burden is associated with a decline in mean connectivity of the default mode network.ABBREVIATIONS: ASLN ¼ auditory-salience-language network; BOLD ¼ blood oxygen level-dependent; DMN ¼ default mode network; FC ¼ functional connectivity; MCS ¼ mean connectivity score; rs-fMRI ¼ resting-state fMRI; rTBV ¼ relative total brain volume; SBP ¼ systolic blood pressure; TBV ¼ total brain volume; WMH ¼ white matter hyperintensities

show abstract

Disrupted topological organization of functional brain networks is associated with cognitive impairment in hypertension patients: a resting-state fMRI study

et al. 2022

View full text Add to dashboard Cite

Changes in brain functional connectivity and cognition related to white matter lesion burden in hypertensive patients from SPRINT

Cited by 11 publications

References 46 publications

Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension

Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension

Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial

Disrupted topological organization of functional brain networks is associated with cognitive impairment in hypertension patients: a resting-state fMRI study

Contact Info

Product

Resources

About