Changes in Calcaneal Trabecular Bone Structure after Heart Transplantation: An MR Imaging Study

Link, Thomas M.; Lotter, Albrecht; Beyer, Florian; Christiansen, Stefan; Newitt, David C.; Lü, Ying; Schmid, Çhristof; Majumdar, Sharmila

doi:10.1148/radiology.217.3.r00dc06855

Cited by 50 publications

(13 citation statements)

References 37 publications

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“…Emerging data indicate that bone microarchitecture offers important information about bone fragility [11–14]. Several studies have demonstrated increased fracture risk associated with abnormal bone microarchitecture and normal BMD, suggesting that microstructure may be a more sensitive measure than BMD in assessing such risk [20]. Parameters of bone microarchitecture are also abnormal in postmenopausal and corticosteroid-induced osteoporosis [21, 22] and are associated with increased fracture risk independent of BMD [23].…”

Section: Discussionmentioning

confidence: 99%

Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa

Lawson

Miller

Bredella

et al. 2010

Bone

115

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Osteopenia is a complication of anorexia nervosa (AN) associated with a two- to three-fold increase in fractures. Nutritional deficits and hormonal abnormalities are thought to mediate AN-induced bone loss. Alterations in bone microarchitecture may explain fracture risk independent of bone mineral density (BMD). Advances in CT imaging now allow for noninvasive evaluation of trabecular microstructure at peripheral sites in vivo. Few data are available regarding bone microarchitecture in AN. We therefore performed a cross-sectional study of 23 women (12 with AN and 11 healthy controls) to determine hormonal predictors of trabecular bone microarchitecture. Outcome measures included bone microarchitectural parameters at the ultradistal radius by flat panel Volume CT (fpVCT); BMD at the PA and lateral spine, total hip, femoral neck and ultradistal radius by dual energy X-ray absorptiometry (DXA); and IGF-I, leptin, estradiol, testosterone and free testosterone levels. Bone microarchitectural measures, including apparent (app.) bone volume fraction, app. trabecular thickness, and app. trabecular number, were reduced (p<0.03) and app. trabecular spacing was increased (p=0.02) in AN vs. controls. Decreased structural integrity at the ultradistal radius was associated with decreased BMD at all sites (p=0.05) except for total hip. IGF-I, leptin, testosterone and free testosterone levels predicted bone microarchitecture. All associations between both IGF-I and leptin levels and bone microarchitectural parameters, and most associations between androgen levels and microarchitecture remained significant after controlling for body mass index. We concluded that bone microarchitecture is abnormal in women with AN. Endogenous IGF-I, leptin and androgen levels predict bone microarchitecture independent of BMI.

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Section: Discussionmentioning

confidence: 99%

Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa

Lawson

Miller

Bredella

et al. 2010

Bone

115

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“…Firstly, a 3-dimensional (3D) excitation usually provides higher SNR than a 2D sequence. However, 2D acquisition techniques have also been used previously to image the trabecular structure of the calcaneus (17–19) albeit with lower spatial resolution. Secondly, the gradient-echo has to be acquired immediately after the excitation pulse in order to avoid signal loss due to T2 relaxation.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

High-Resolution Imaging Techniques for the Assessment of Osteoporosis

Krug¹,

Burghardt²,

Majumdar³

et al. 2010

Radiologic Clinics of North America

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197

125

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SynopsisThe importance of assessing the bone's microarchitectural make-up in addition to its mineral density in the context of osteoporosis has been emphasized in a number of publications. The high spatial resolution required to resolve the bone's microstructure in a clinically feasible scan time is challenging. Currently, the best suited modalities meeting these requirements in vivo are highresolution peripheral quantitative imaging (HR-pQCT) and magnetic resonance imaging (MRI). Whereas HR-pQCT is limited to peripheral skeleton regions like the wrist and ankle, MRI can also image other sites like the proximal femur but usually with lower spatial resolution. In addition Multidetector-CT has been used for high-resolution imaging of trabecular bone structure, however, the radiation dose is a limiting factor. This article provides an overview of the different modalities, technical requirements and recent developments in this emerging field. Details regarding imaging protocols as well as image post-processing methods for bone structure quantification are discussed.

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“…Studies in other populations, such as transplant patients [45], hypogonadal men [46], and patients with osteoarthritis [34] have also been initiated, as the promise of assessing trabecular bone microarchitecture noninvasively has clearly been established over the past decade. Chesnut et al [17••] published the first longitudinal study showing that nasal spray calcitonin preserves trabecular bone microarchitecture in the distal radius.…”

Section: Clinical Relevance Of Bone Microarchitecturementioning

confidence: 99%

Clinical utility of microarchitecture measurements of trabecular bone

Carballido‐Gamio¹,

Majumdar

2006

Curr Osteoporos Rep

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Osteoporosis is a metabolic disorder that manifests changes in bone density and structure accompanied by an increased susceptibility to fractures. Recent studies have demonstrated the potential contributions of trabecular bone microarchitecture in the assessment of the therapeutic efficacy of emerging treatments, and also in the assessment of fracture risk. The main goal of this paper is to emphasize the clinical implementation of bone microarchitecture measurements. Thus, this paper provides an overview of the main imaging modalities for depicting trabecular bone microarchitecture and a corresponding description of common computed structural bone parameters. The imaging modalities presented to characterize the complex three-dimensional trabecular bone network include micro-CT, quantitative CT, and magnetic resonance imaging. Two-dimensional analyses of radiographic patterns are also discussed. Results demonstrating the ability to distinguish between different populations based on trabecular bone microarchitecture in longitudinal studies are also presented for the various imaging modalities.

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Changes in Calcaneal Trabecular Bone Structure after Heart Transplantation: An MR Imaging Study

Abstract: MR imaging-derived structure measurements in the calcaneus are useful for monitoring bone changes after heart transplantation and assessing vertebral fracture status.

Cited by 50 publications

References 37 publications

Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa

Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa

High-Resolution Imaging Techniques for the Assessment of Osteoporosis

Clinical utility of microarchitecture measurements of trabecular bone

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