Changes in Calcium and Hydroxyproline Content of Cortical Bone after Compression and Neutral Plate Fixation

Paavolainen, Pekka; Slätis, P; Ahonen, J; Karaharju, Erkki

doi:10.3109/17453677808993228

Cited by 4 publications

(2 citation statements)

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“…Previous studies concerning the chemical changes after rigid plate fixation in intact bones (Paavolainen et al 1978a(Paavolainen et al , 1978b revealed only a slight increase in the content of hydroxyproline, reflecting formation of new bone subperiosteally and endosteally. LOSS of calcium content of about 15 per cent occurred during the first 2 weeks postoperatively, but there was no evidence of progressive loss of calcium, as might have been expected from the histological observations on progressive structural derangement of the bone towards the end of the experiment.…”

Section: Discussionmentioning

confidence: 84%

“…The aim of the present study was to analyse the morphometric and chemical changes after rigid plate fixation of experimental osteotomies and to compare these alterations with those earlier reported for fractures treated without any internal fixation (Penttinen 1972). The effect of these alterations on the reduced mechanical strength of bone after rigid plate fixation of fractures (Braden et al 1973, Paavolainen et al 1978a) will be discussed.…”

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confidence: 99%

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The Healing of Experimental Fractures by Compression Osteosynthesis: II.Morphometric and Chemical Analysis

Paavolainen

Penttinen

Slätis

et al. 1979

Acta Orthopaedica Scandinavica

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The effects of rigid plate fixation on the structure and chemical composition of bones during healing of experimental fractures were studied by morphometric and chemical analysis at intervals of 3 to 24 weeks after attachment of six-hole AO plates to osteotomized rabbit tibiae. After fracture union gradual porotic transformation could be observed from 9 weeks onwards, with rapid excavation and breakdown of the cortical wall. During the study over 24 weeks the degree of porosity increased from 9.0 +/- 4.8 per cent to 37.5 +/- 10.2 per cent (P less than 0.001). This osteoporosis was accompanied by formation of new subperiosteal bone. The changes in the tubular bone led to a progressive increase in overall diameter and in the area occupied by the medullary cavity throughout the experiment. In the osteotomy area increased values were found for the content of hexosamines and the ratio of hexosamines to hydroxyproline at 3 weeks, indicating formation of connective tissue in the fracture area. Later on, no chemical signs of callus formation could be detected. In spite of the slight increase in the content by hydroxyproline, reflecting the formation of new bone subperiosteally, the chemical composition of the unresorbed cortical bone remained unchanged.

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Section: Discussionmentioning

confidence: 84%

mentioning

confidence: 99%

The Healing of Experimental Fractures by Compression Osteosynthesis: II.Morphometric and Chemical Analysis

Paavolainen

Penttinen

Slätis

et al. 1979

Acta Orthopaedica Scandinavica

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Quantitative microradiography of cortical bone in disuse osteoporosis following fracture fixation

1983

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Carpal Arthrodesis in Dogs

Johnson

1980

Aust Veterinary J

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Nine dogs, each with a severe carpal sprain injury, were treated by arthrodesis (2 bilateral). The same surgical technique with articular cartilage curettage, autologous bone grafting and compression plate fixation was used for each carpus. Initial treatment with external coaptation had been unsuccessful, but arthrodesis always resulted in resolution of the lameness. Complications included fracture of the compression plate (1 case) and loosening of the implants (2 cases).

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Changes in Calcium and Hydroxyproline Content of Cortical Bone after Compression and Neutral Plate Fixation

Cited by 4 publications

References 10 publications

The Healing of Experimental Fractures by Compression Osteosynthesis: II.Morphometric and Chemical Analysis

The Healing of Experimental Fractures by Compression Osteosynthesis: II.Morphometric and Chemical Analysis

Quantitative microradiography of cortical bone in disuse osteoporosis following fracture fixation

Carpal Arthrodesis in Dogs

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