Objective: The present study investigated the health-related quality of life (QOL) of patients with acute myocardial infarction (AMI) who were treated with percutaneous coronary intervention (PCI). Methods: Forty-three patients were asked to complete the SF-36 questionnaire at discharge and 6 months after discharge. The SF-36 consists of 8 subscales: Physical Functioning (PF), Role Physical (RP), Bodily Pain (BP), General Health perception (GH), Vitality (VT), Social Functioning (SF), Role Emotional (RE), and Mental Health (MH). We calculated mean scores and standard deviations for these 8 subscales at discharge and 6 months after discharge. Values were compared using the paired student ttest. Results: The PF and BP scores after 6 months were significantly higher than those at discharge, but there were no significant differences in the other subscales. Conclusions: Some of the physical parameters of healthrelated QOL may improve 6 months after discharge in AMI patients treated with PCI. Since PCI may relieve symptoms such chest pain and chest discomfort, these patients can gradually extend their daily activities. While the physical state may improve, mental health-related QOL does not appear to improve 6 months after discharge.