Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

Duselis, Amanda R.; Obergfell, Craig; Mack, Jennifer A.; O’Neill, Michael; Nguyen, Quang; O’Neill, Rachel J.; Vrana, Paul B.

doi:10.1071/rd07015

Cited by 6 publications

(10 citation statements)

References 76 publications

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“…Moreover, the walls of the maternal blood sinuses within the female PO 3 male BW labyrinth typically appear thinner and often compromised. These defects are consistent with the previously documented reduction in female PO 3 male BW placental collagen expression as well as similar hemorrhaging in the associated embryos [11,20].…”

Section: Duselis and Vranasupporting

confidence: 91%

“…This suggests that a possible underlying cause of embryonic death may be failure of maternal-fetal nutrient transfer due to blood vessel instability in the labyrinth. Moreover, our previous research suggested a deficiency of some ECM-related proteins in female PO 3 male BW placentas [20]. …”

Section: Female Po 3 Male Bw Hybrid Placental Hemorrhagingmentioning

confidence: 90%

“…Cdkn1c and H19 are linked imprinted loci that we have previously shown to exhibit female PO 3 male BW hybrid misexpression [18][19][20]. While both are normally expressed from the maternal allele, H19 exhibits increased (biallelic) female PO 3 male BW expression, while placental Cdkn1c expression is reduced.…”

Section: Labyrinth and Junctional Zone Markersmentioning

confidence: 95%

“…As we previously found genes encoding cell-cycle regulators to be affected in the hybrid placentas [20], we investigated whether gross differences in cellular proliferation and death were apparent in the hybrid placentas. We utilized BrdU incorporation to measure proliferation and TUNEL staining, which identifies cells with DNA fragmentation typically resulting from apoptosis.…”

Section: Proliferation and Cell Deathmentioning

confidence: 99%

“…The hybrid placentas (particularly female PO 3 male BW) have been shown to misexpress extracellular matrix (ECM)-related loci, loci-encoding cell-cycle regulators, and loci subject to genomic imprinting [18][19][20]. Numerous imprinted gene products have been documented as playing significant roles in mammalian placental growth and development [21].…”

Section: Introductionmentioning

confidence: 99%

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Aberrant Growth and Pattern Formation in Peromyscus Hybrid Placental Development1

Duselis

Vrana

2010

Biology of Reproduction

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Crosses between the North American deer mouse species Peromyscus maniculatus (BW) and P. polionotus (PO) produce dramatic asymmetric developmental effects. BW females mated to PO males (female bw × male po) produce viable growth-retarded offspring. In contrast, PO females mated to BW males (female PO × male BW) produce overgrown but dysmorphic conceptuses. Most female PO × male BW offspring are dead by midgestation; those surviving to later time points display numerous defects reminiscent of several diseases. The hybrid effects are particularly pronounced in the placenta. Here we examine placental morphological defects via histology and in situ hybridization as well as the relationship between growth and mortality in the female PO × male BW cross. These assays indicate altered hybrid fetal:placental ratios by the equivalent of mouse (Mus) Embryonic Day (E) 13 and disorganization and labyrinth defects in female PO × male BW placentas and confirm earlier suggestions of a severely reduced junctional zone in the female bw × male po hybrids. Further, we show that both cellular proliferation and death are abnormal in the hybrids through BrdU incorporation and TUNEL assays, respectively. Together the data indicate that the origin of the effects is prior to the equivalent of Mus E10. Finally, as the majority of these assays had not previously been performed on Peromyscus, these studies provide comparative data on wild-type placentation.

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Section: Duselis and Vranasupporting

confidence: 91%

Section: Female Po 3 Male Bw Hybrid Placental Hemorrhagingmentioning

confidence: 90%

Section: Labyrinth and Junctional Zone Markersmentioning

confidence: 95%

Section: Proliferation and Cell Deathmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aberrant Growth and Pattern Formation in Peromyscus Hybrid Placental Development1

Duselis

Vrana

2010

Biology of Reproduction

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Peromyscus (deer mice) as developmental models

Vrana

Shorter

Szalai

et al. 2013

WIREs Developmental Biology

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Deer mice (Peromyscus) are the most common native North American mammals, and exhibit great natural genetic variation. Wild-derived stocks from a number of populations are available from the Peromyscus Genetic Stock Center (PGSC). The PGSC also houses a number of natural variants and mutants (many of which appear to differ from Mus). These include metabolic, coat-color/pattern, neurological, and other morphological variants/mutants. Nearly all these mutants are on a common genetic background, the Peromyscus maniculatus BW stock. Peromyscus are also superior behavior models in areas such as repetitive behavior and pair-bonding effects, as multiple species are monogamous. While Peromyscus development generally resembles that of Mus and Rattus, prenatal stages have not been as thoroughly studied, and there appear to be intriguing differences (e.g., longer time spent at the two-cell stage). Development is greatly perturbed in crosses between P. maniculatus (BW) and Peromyscus polionotus (PO). BW females crossed to PO males produce growth-restricted, but otherwise healthy, fertile offspring which allows for genetic analyses of the many traits that differ between these two species. PO females crossed to BW males produce overgrown but severely dysmorphic conceptuses that rarely survive to late gestation. There are likely many more uses for these animals as developmental models than we have described here. Peromyscus models can now be more fully exploited due to the emerging genetic (full linkage map), genomic (genomes of four stocks have been sequenced) and reproductive resources.

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Epigenetic Programming: The Challenge to Species Hybridization

Ishikawa

Kinoshita

2009

Molecular Plant

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In many organisms, the genomes of individual species are isolated by a range of reproductive barriers that act before or after fertilization. Successful mating between species results in the presence of different genomes within a cell (hybridization), which can lead to incompatibility in cellular events due to adverse genetic interactions. In addition to such genetic interactions, recent studies have shown that the epigenetic control of the genome, silencing of transposons, control of non-additive gene expression and genomic imprinting might also contribute to reproductive barriers in plant and animal species. These genetic and epigenetic mechanisms play a significant role in the prevention of gene flow between species. In this review, we focus on aspects of epigenetic control related to hybrid incompatibility during species hybridization, and also consider key mechanism(s) in the interaction between different genomes.

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Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

Cited by 6 publications

References 76 publications

Aberrant Growth and Pattern Formation in Peromyscus Hybrid Placental Development1

Aberrant Growth and Pattern Formation in Peromyscus Hybrid Placental Development1

Peromyscus (deer mice) as developmental models

Epigenetic Programming: The Challenge to Species Hybridization

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