Changes in cellular immunity among workers occupationally exposed to styrene in a plastics lamination plant

Tulinská, Jana; Dušinská, Maria; Jahnová, E; Líšková, Aurélia; Kuricová, Miroslava; Vodička, Pavel; Vodičková, Ľudmila; Sulcová, M; Fuortes, Laurence J.

doi:10.1002/1097-0274(200011)38:5<576::aid-ajim10>3.0.co;2-f

Cited by 22 publications

(7 citation statements)

References 15 publications

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“…Environmental and occupational chemical pollutants, for example, cigarette smoke, styrene, can also alter immune functions. 38,39 We also proved an additive effect between ionizing irradiation and ETO exposure in uncontrolled conditions. 7,23 However, at all the controlled workplaces the cytogenetic end points remained at the nonexposed control level, and a strict quality control according to ISO 9001 resulted in an even lower CA yield corresponding to the healthy unexposed population.…”

Section: Discussionsupporting

confidence: 55%

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Chemical Safety and Health Conditions among Hungarian Hospital Nurses

Tompa

Jakab²,

Bíró³

et al. 2006

Annals of the New York Academy of Sciences

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In the present study genotoxicological and immunotoxicological follow-up investigations were made on 811 donors including 94 unexposed controls and 717 nurses with various working conditions from different hospitals (The Hungarian Nurse Study). The nurses were exposed to different chemicals: cytostatic drugs, anesthetic, and sterilizing gases, such as ethylene oxide (ETO) and formaldehyde. The measured biomarkers were: clinical laboratory routine tests, completed with genotoxicological (chromosome aberrations [CA], sister chromatid exchange [SCE]), and immune-toxicological monitoring (ratio of lymphocyte subpopulations, lymphocyte activation markers, and leukocyte oxidative burst). The highest rate of genotoxicologically affected donors (25.4%) was found in the group of cytostatic drug-exposed nurses. Comparing geno- and immunotoxicological effect markers, we found that among genotoxicologically affected donors the frequency of helper T cell (Th) lymphocytes, the ratio of activated T and B cells increased, whereas the oxidative burst of leukocytes decreased. In hospitals with lack of protective measures increased CA yields were observed compared to those with ISO 9001 quality control or equivalent measures. Anemia, serum glucose level, thyroid dysfunctions, benign, and malignant tumors were more frequent in the exposed groups than in controls. The hygienic standard of the working environment is the basic risk factor for the vulnerability of nurses. On the basis of these results, it is suggested, that the used cytogenetic and immunological biomarkers are appropriate to detect early susceptibility to diseases. The Hungarian Nurse Study proved that the use of safety measures could protect against occupational exposure at work sites handling cytostatic drugs, anesthetic, and sterilizing gases.

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Section: Discussionsupporting

confidence: 55%

“…SCE values in smokers were significantly increased in all investigated subgroups compared to nonsmokers. Environmental and occupational chemical pollutants, for example, cigarette smoke, styrene, can also alter immune functions 38,39 …”

Section: Discussionmentioning

confidence: 99%

Chemical Safety and Health Conditions among Hungarian Hospital Nurses

Tompa

Jakab²,

Bíró³

et al. 2006

Annals of the New York Academy of Sciences

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“…Human exposure to styrene occurs by routes depending on occupation, place of residence, and lifestyle. However, styrene and its metabolites are known to have serious negative effects on human health [13, 14]; therefore, before discharge to the environment, both the liquid and gaseous effluents of petrochemical complexes should undergo an appropriate treatment to decrease the concentration of styrene to below toxic levels [15]. Styrene and its derivatives are also polymerized via both cationic and radical routes and even with transition‐metal complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, biological activity, and thermal stability of new styrenic polymer having pendant ketone and its some derivatives

Erol

Şahin

Özcan

2012

Polymer Engineering & Sci

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A new type of styrene monomer, 1‐{4‐[(4‐vinylbenzyl)oxy]phenyl}ethanone (VBOPE), was synthesized. The oxime, phenylhydrazone, toluol‐4‐sulfonic acid hydrazone, and thiosemicarbazone (TSC) derivatives of VBOPE were prepared with hydroxylamine hydrochloride, phenylhydrazine, toluol‐4‐sulfonic acid hydrazine, and TSC hydrochloride, respectively. Radical homopolymerization of the monomers were prepared at 65°C in 1,4‐dioxane solution with benzoylperoxide as an initiator. The compounds was characterized with Fourier transform infrared and NMR techniques. The thermal properties of polymers were investigated with thermogravimetric analysis and differential scanning calorimetry. The activation energies of the thermal degradation of the polymers were calculated with the Ozawa and Kissinger method. The antibacterial and antifungal effects of the monomer and the polymer and its derivatives were also investigated on various bacteria and fungi. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers

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“…The prevalence of these compounds in the atmosphere means that exposure to organic solvents is generally unavoidable and humans are frequently exposed to low levels for prolonged periods. Although, there has been some evidence of immunotoxic effects in animals and humans exposed to volatile organic solvents, as well as from in vitro studies (Hsieh et al, 1989;Farris et al, 1997;Tulinska et al, 2000;Palermo-Neto et al, 2001;Wichmann et al, 2005;McDermott et al, 2007), data remain limited regarding the immunological alterations induced by exposure to these compounds.…”

Section: Introductionmentioning

confidence: 99%

Different sensitivity in expression of transcription factor mRNAs in congenic mice following exposure to low-level toluene

Fujimaki

Win-Shwe

Yamamoto

et al. 2010

Inhalation Toxicology

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To investigate the relationship between sensitivity to toluene exposure and genetic background, male congenic mice, C57BL/10 (H-2(b)) and B10.BR/Sg (H-2(k)) were exposed to 0, 5, and 50 ppm toluene for 6 h per day, 5 days per week for 6 weeks. Groups of mice were injected with ovalbumin (OVA) intraperitoneally before starting exposure schedule and these mice were then challenged with aerosolized OVA as a booster. Following 24 h of the last exposure, the spleens were collected. We examined spleen cell proliferation using DNA synthesis and T-helper 1/2-related transcription factor genes in spleen of two congenic mice using real-time reverse transcriptase-polymerase chain reaction. Although lipopolysaccharide-induced (LPS-induced) cell proliferation was significantly increased in 50 ppm toluene-exposed, nonimmunized B10.BR mice but not in C57BL/10 mice, exposure to 50 ppm toluene significantly decreased LPS-induced cell proliferation in immunized B10.BR mice. The expression of transcription factor forkhead box P3, signal transducers and activators of transcription (STAT)5 and STAT6 mRNAs was significantly increased in spleen from 5 ppm toluene-exposed, OVA-immunized B10.BR mice, but not in those of C57BL/10 mice. Although there may be other differences unrelated to H-2 locus between the congenic mice of the same background, the findings of the present study strongly suggest a possible role of H-2 locus in the toluene-induced immune disturbance.

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Changes in cellular immunity among workers occupationally exposed to styrene in a plastics lamination plant

Cited by 22 publications

References 15 publications

Chemical Safety and Health Conditions among Hungarian Hospital Nurses

Chemical Safety and Health Conditions among Hungarian Hospital Nurses

Synthesis, characterization, biological activity, and thermal stability of new styrenic polymer having pendant ketone and its some derivatives

Different sensitivity in expression of transcription factor mRNAs in congenic mice following exposure to low-level toluene

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