2014
DOI: 10.1016/j.cbi.2014.08.007
|View full text |Cite
|
Sign up to set email alerts
|

Changes in cellular thiol content and intracellular Zn2+ level by 1,4-naphthoquinone in rat thymocytes

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
7
0

Year Published

2014
2014
2022
2022

Publication Types

Select...
5

Relationship

2
3

Authors

Journals

citations
Cited by 5 publications
(7 citation statements)
references
References 36 publications
0
7
0
Order By: Relevance
“…NAPH causes in vitro and in vivo toxicities (Wilson et al, 1996;Lamé et al, 2003;Ishihara et al, 2011) via the formation of reactive oxygen species (Kumar et al, 2009;Srinivas et al, 2011). In our previous study (Fukunaga et al, 2014), we showed that NAPH at sublethal concentrations increased the intracellular Zn 2+ levels in rat thymocytes. This phenomenon is one of the common features of cells affected by oxidative stress because the conversion of thiols to disulfides by oxidative stress releases Zn 2+ (Maret, 1994), resulting in an increase in intracellular Zn 2+ levels (Kinazaki et al, 2011).…”
Section: Introductionmentioning
confidence: 74%
See 2 more Smart Citations
“…NAPH causes in vitro and in vivo toxicities (Wilson et al, 1996;Lamé et al, 2003;Ishihara et al, 2011) via the formation of reactive oxygen species (Kumar et al, 2009;Srinivas et al, 2011). In our previous study (Fukunaga et al, 2014), we showed that NAPH at sublethal concentrations increased the intracellular Zn 2+ levels in rat thymocytes. This phenomenon is one of the common features of cells affected by oxidative stress because the conversion of thiols to disulfides by oxidative stress releases Zn 2+ (Maret, 1994), resulting in an increase in intracellular Zn 2+ levels (Kinazaki et al, 2011).…”
Section: Introductionmentioning
confidence: 74%
“…In our previous study, NAPH significantly increased cell lethality at a concentration ≥ 3 μM (Fukunaga et al, 2014). The experiments in the current study were carried out with sublethal concentrations (0.1-1 μM) of NAPH.…”
Section: The Effect Of Naph On the H 2 O 2 -Induced Increase In Cell mentioning
confidence: 92%
See 1 more Smart Citation
“…However, some cautions may be necessary to interpret Zn 2+ -mediated actions. We showed that small increase in intracellular Zn 2+ concentrations increased cellular content of nonprotein thiols [14,28,42]. The Zn 2+ -induced increase in cellular content of nonprotein thiols (glutathione) by chemical compounds may be cytoprotective against oxidative stress.…”
Section: Toxicological Implicationsmentioning
confidence: 84%
“…Zn 2+ influx into cells under control conditions was significantly reduced at low temperatures [14]. To determine if the Ziram-induced influx of Zn 2+ is sensitive to temperature, the effect of 0.3-1 lM Ziram on FluoZin-3 fluorescence was examined under cold conditions (3-4°C).…”
Section: Ziram-induced Augmentation Of Fluozin-3 Fluorescence Under Cmentioning
confidence: 99%