Changes in cerebral arterial pulsatility and hippocampal volume: a transcranial doppler ultrasonography study

Miller, Marion G.; Ghisletta, Paolo; Jacobs, Bradley S.; Dahle, Cheryl L.; Raz, Naftali

doi:10.1016/j.neurobiolaging.2021.08.014

Cited by 5 publications

(3 citation statements)

References 63 publications

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“…The age-volume associations were not surprising for an age where atrophy likely have set in, and the non-significant links for 8/15 regions likely reflect a narrow age span and a small cohort. However, the positive volume-pulsatility correlation for one brain region (frontal WM) contradicts previous findings of inverse relationships between regional brain volumes and pulsatility 41 , 48 , but should not be interpreted as significant when the 14 other regions showed no association.…”

Section: Discussioncontrasting

confidence: 75%

Blood–brain barrier integrity is linked to cognitive function, but not to cerebral arterial pulsatility, among elderly

Vikner,

Garpebring,

Björnfot

et al. 2024

Sci Rep

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Blood–brain barrier (BBB) disruption may contribute to cognitive decline, but questions remain whether this association is more pronounced for certain brain regions, such as the hippocampus, or represents a whole-brain mechanism. Further, whether human BBB leakage is triggered by excessive vascular pulsatility, as suggested by animal studies, remains unknown. In a prospective cohort (N = 50; 68–84 years), we used contrast-enhanced MRI to estimate the permeability-surface area product (PS) and fractional plasma volume ($${v}_{p}$$ v p ), and 4D flow MRI to assess cerebral arterial pulsatility. Cognition was assessed by the Montreal Cognitive Assessment (MoCA) score. We hypothesized that high PS would be associated with high arterial pulsatility, and that links to cognition would be specific to hippocampal PS. For 15 brain regions, PS ranged from 0.38 to 0.85 (·10−3 min−1) and $${v}_{p}$$ v p from 0.79 to 1.78%. Cognition was related to PS (·10−3 min−1) in hippocampus (β = – 2.9; p = 0.006), basal ganglia (β = – 2.3; p = 0.04), white matter (β = – 2.6; p = 0.04), whole-brain (β = – 2.7; p = 0.04) and borderline-related for cortex (β = – 2.7; p = 0.076). Pulsatility was unrelated to PS for all regions (p > 0.19). Our findings suggest PS–cognition links mainly reflect a whole-brain phenomenon with only slightly more pronounced links for the hippocampus, and provide no evidence of excessive pulsatility as a trigger of BBB disruption.

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Section: Discussioncontrasting

confidence: 75%

Blood–brain barrier integrity is linked to cognitive function, but not to cerebral arterial pulsatility, among elderly

Vikner,

Garpebring,

Björnfot

et al. 2024

Sci Rep

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“… 37 , 38 However, periventricular white matter is supplied by long arteries that branch into tortuous arterioles, 39 potentially limiting the transfer of hemodynamic stress. 40 Instead, brain regions with a vascular supply characterized by short arterial branches that provide little damping‐capacity could be particularly susceptible to pulsatile stress, potentially explaining why pulsatility correlates negatively with hippocampal volume 41 , 42 and episodic memory. 16 Importantly, BBB breakdown begins in the hippocampus and accelerates cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

5‐Year Associations among Cerebral Arterial Pulsatility, Perivascular Space Dilation, and White Matter Lesions

Vikner

Karalija

Eklund

et al. 2022

Annals of Neurology

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High cerebral arterial pulsatility index (PI), white matter lesions (WMLs), enlarged perivascular spaces (PVSs), and lacunar infarcts are common findings in the elderly population, and considered indicators of small vessel disease (SVD). Here, we investigate the potential temporal ordering among these variables, with emphasis on determining whether high PI is an early or delayed manifestation of SVD. Methods: In a population-based cohort, 4D flow MRI data for cerebral arterial pulsatility was collected for 159 participants at baseline (age 64-68), and for 122 participants at follow-up 5 years later. Structural MRI was used for WML and PVS segmentation, and lacune identification. Linear mixed-effects (LME) models were used to model longitudinal changes testing for pairwise associations, and latent change score (LCS) models to model multiple relationships among variables simultaneously. Results: Longitudinal 5-year increases were found for WML, PVS, and PI. Cerebral arterial PI at baseline did not predict changes in WML or PVS volume. However, WML and PVS volume at baseline predicted 5-year increases in PI. This was shown for PI increases in relation to baseline WML and PVS volumes using LME models (R ≥ 0.24; p < 0.02 and R ≥ 0.23; p < 0.03, respectively) and LCS models (β = 0.28; p = 0.015 and β = 0.28; p = 0.009, respectively). Lacunes at baseline were unrelated to PI. Interpretation: In healthy older adults, indicators of SVD are related in a lead-lag fashion, in which the expression of WML and PVS precedes increases in cerebral arterial PI. Hence, we propose that elevated PI is a relatively late manifestation, rather than a risk factor, for cerebral SVD.

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“…Dopamine D2 measures in the caudate revealed significant differences between WM groups at both waves, and similar observations have been made in prefrontal regions 24 . Vascular health has been linked to www.nature.com/scientificreports/ maintained brain integrity and preserved cognition 25,26 , and a growing literature suggests that excessive microvascular pulsatility can have harmful cerebral and cognitive effects 19,[27][28][29] , with marked influences on hippocampal structural and functional integrity and higher white-matter lesion burden [30][31][32] , which in turn can influence dopaminergic neurotransmission 12,33 . Moreover, excessive pulsatility may affect the blood-brain barrier 34 and impair neurovascular coupling 35,36 , thereby influencing brain activity on tasks that require sustained processing over time 26 .…”

Section: Discussionmentioning

confidence: 99%

Longitudinal stability in working memory and frontal activity in relation to general brain maintenance

Nyberg

Karalija

Papenberg

et al. 2022

Sci Rep

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Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline age = 64–68 years) into having stable or declining working-memory (WM). Consistent with a vital role of the prefrontal cortex (PFC), WM stability or decline was related to maintained or reduced longitudinal PFC functional responses. Subsequent analyses of imaging markers of general brain maintenance revealed higher levels in the stable WM group on measures of neurotransmission and vascular health. Also, categorical and continuous analyses showed that rate of WM decline was related to global (ventricles) and local (hippocampus) measures of neuronal integrity. Thus, our findings support a role of the PFC as well as general brain maintenance in explaining heterogeneity in longitudinal WM trajectories in aging.

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Changes in cerebral arterial pulsatility and hippocampal volume: a transcranial doppler ultrasonography study

Cited by 5 publications

References 63 publications

Blood–brain barrier integrity is linked to cognitive function, but not to cerebral arterial pulsatility, among elderly

Blood–brain barrier integrity is linked to cognitive function, but not to cerebral arterial pulsatility, among elderly

5‐Year Associations among Cerebral Arterial Pulsatility, Perivascular Space Dilation, and White Matter Lesions

Longitudinal stability in working memory and frontal activity in relation to general brain maintenance

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