Changes in Cerebral Blood Flow and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage

Yang, Jianye; Jie, Jing; Chen, Shiling; Liu, Xia; Tang, Yingxin; Pan, Chao; Tang, Zhouping

doi:10.1007/s12975-022-00998-6

Cited by 9 publications

(2 citation statements)

References 173 publications

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“…Compared to ischemic stroke, white matter injury, and demyelination after intracerebral hemorrhage (ICH) have been relatively poorly studied. However, post-ICH, white matter injury, and secondary ischemic lesions are also not uncommon [34,[235][236][237]. White matter lesions after brain hemorrhage are often associated with poor outcomes [238][239][240][241].…”

Section: Hv1 Demyelination and Myelin Repair In Strokementioning

confidence: 99%

The Emerging Role of Microglial Hv1 as a Target for Immunomodulation in Myelin Repair

Tang,

Wu,

et al. 2023

Aging and disease

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In the central nervous system (CNS), the myelin sheath ensures efficient interconnection between neurons and contributes to the regulation of the proper function of neuronal networks. The maintenance of myelin and the well-organized subtle process of myelin plasticity requires cooperation among myelin-forming cells, glial cells, and neural networks. The process of cooperation is fragile, and the balance is highly susceptible to disruption by microenvironment influences. Reactive microglia play a critical and complicated role in the demyelination and remyelination process. Recent studies have shown that the voltage-gated proton channel Hv1 is selectively expressed in microglia in CNS, which regulates intracellular pH and is involved in the production of reactive oxygen species, underlying multifaceted roles in maintaining microglia function. This paper begins by examining the molecular mechanisms of demyelination and emphasizes the crucial role of the microenvironment in demyelination. It focuses specifically on the role of Hv1 in myelin repair and its therapeutic potential in CNS demyelinating diseases.

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Section: Hv1 Demyelination and Myelin Repair In Strokementioning

confidence: 99%

The Emerging Role of Microglial Hv1 as a Target for Immunomodulation in Myelin Repair

Tang,

Wu,

et al. 2023

Aging and disease

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“…Moreover, brain aneurysms and ruptured arteriovenous malformation (AVM) can cause cerebral hemorrhages and are associated with increased morbidity and mortality, especially in young individuals [ 7 , 8 ]. Instead, cerebral ischemia is caused by a clot-induced interruption of blood flow triggering hypoxic conditions and nutrient deprivation of the cerebral tissue [ 9 , 10 , 11 , 12 ]. The lack of cerebral blood supply induces a massive necrosis and an irreversible neuronal damage that prompts a significant release of glutamate with consequent hyperactivation of the N-methyl-D-Aspartate (NMDA) receptors.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular and Neuronal Consequences of Thyroid Hormones Alterations in the Ischemic Stroke

et al. 2022

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Ischemic stroke is one of the leading global causes of neurological morbidity and decease. Its etiology depends on multiple events such as cardiac embolism, brain capillaries occlusion and atherosclerosis, which ultimately culminate in blood flow interruption, incurring hypoxia and nutrient deprivation. Thyroid hormones (THs) are pleiotropic modulators of several metabolic pathways, and critically influence different aspects of tissues development. The brain is a key TH target tissue and both hypo- and hyperthyroidism, during embryonic and adult life, are associated with deranged neuronal formation and cognitive functions. Accordingly, increasing pieces of evidence are drawing attention on the consistent relationship between the THs status and the acute cerebral and cardiac diseases. However, the concrete contribution of THs systemic or local alteration to the pathology outcome still needs to be fully addressed. In this review, we aim to summarize the multiple influences that THs exert on the brain and heart patho-physiology, to deepen the reasons for the harmful effects of hypo- and hyperthyroidism on these organs and to provide insights on the intricate relationship between the THs variations and the pathological alterations that take place after the ischemic injury.

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Perihematomal oligemia is associated with progression to ischemia and poor outcome in a subset of patients with intracerebral hemorrhage

Fainardi,

Busto,

Bernardoni

et al. 2024

Eur Radiol

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Changes in Cerebral Blood Flow and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage

Cited by 9 publications

References 173 publications

The Emerging Role of Microglial Hv1 as a Target for Immunomodulation in Myelin Repair

The Emerging Role of Microglial Hv1 as a Target for Immunomodulation in Myelin Repair

Cardiovascular and Neuronal Consequences of Thyroid Hormones Alterations in the Ischemic Stroke

Perihematomal oligemia is associated with progression to ischemia and poor outcome in a subset of patients with intracerebral hemorrhage

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