Changes in choroidal thickness during pregnancy detected by enhanced depth imaging optical coherence tomography

Dadacı, Zeynep; Alptekın, Husnu; Acır, Nurşen Öncel; Borazan, Mehmet

doi:10.1136/bjophthalmol-2014-306343

Cited by 37 publications

(40 citation statements)

References 27 publications

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“…Vance et al 40 showed the effects of sildenafil citrate (phosphodiesterase-5 inhibitor) on the choroidal thickness by vasodilatory effect of nitric oxide. Dadaci et al 41 compared the choroidal thickness measurements of healthy pregnant women obtained in the first trimester with measurements obtained in the third trimester. They reported a significant decrease in choroidal thickness in the period of the third trimester due to vasoconstriction related to the increased adrenoreceptor activity and higher α1-adrenoreceptor concentration in this period.…”

Section: Discussionmentioning

confidence: 99%

Changes in Choroidal Thickness in and Outside the Macula After Hemodialysis in Patients With End-Stage Renal Disease

Chang

Lee

Kim

2017

Retina

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Section: Discussionmentioning

confidence: 99%

Changes in Choroidal Thickness in and Outside the Macula After Hemodialysis in Patients With End-Stage Renal Disease

Chang

Lee

Kim

2017

Retina

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“…Twelve studies [2, 21-31] with a total of 1,053 participants (479 healthy pregnant women and 574 healthy nonpregnant women) were included. As shown in Figure 2, the CT of the healthy pregnancy group (μm, WMD = 34.19, 95% CI: 20.63–47.76) was significantly higher than the controls (Test of WMD = 0: z = 4.94, p = 0.000).…”

Section: Resultsmentioning

confidence: 99%

“…At different pregnant periods, changes in the CT have been found. Goktas et al [26] suggested that choroid could be thickened during the second trimester, and Dadaci et al [2] found that the CT was significantly decreased in healthy pregnant women during the third trimester compared to the first trimester. Second, except for those discussed above, there still exist variables that might differ among studies, such as the diopters of the eyes and the intraocular pressures.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Comparison of Choroidal Thickness in Preeclamptic, Healthy Pregnant, and Nonpregnant Women: A Systematic Review and Meta-Analysis

Jiang

Yang

et al. 2019

Ophthalmic Res

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Purpose: To compare the choroidal thickness (CT) measured by enhanced depth imaging optical coherence tomography (EDI-OCT) in preeclamptic, healthy pregnant, and healthy nonpregnant women. Methods: Studies that focused on the CT evaluation of pregnant women were retrieved by searching PubMed, Embase, Ovid, Cochrane, and Web of Science. We used Stata 14.0 SE for the meta-analysis and presented the results as the weighted mean difference (WMD) with a corresponding 95% CI. Results: A total of 14 studies with 1,227 participants were included in our meta-analysis. The CT of the healthy pregnancies (μm, WMD = 34.19, 95% CI: 20.63–47.76) was significantly higher than that of the nonpregnancies (Test of WMD = 0: z = 4.94, p = 0.000), but the CT of the preeclampsia (μm, WMD = 54.30, 95% CI: –13.40 to 122.01) was not significantly different from the nonpregnancies (Test of WMD = 0: z = 1.57, p = 0.116). In the preeclampsia versus healthy pregnancy group, 3 studies found that the choroid was thinner with preeclampsia, only one study found the CT increased. Conclusions: This meta-analysis suggested that the CT of the healthy pregnant women was significantly higher than that of the nonpregnant women. The presence of preeclampsia might complicate this situation. Most studies found that the CT decreased in the preeclamptic patients because of the increases in the systemic vasospasm and the blood pressure, which led to no significant difference compared with the nonpregnant women.

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“…To date, 10 studies have been done to discover the association between choroidal thickness and pregnancy [37, 52–60]. And the age of volunteers in all groups was matched.…”

Section: The Choroidal Thickness In Gestationmentioning

confidence: 99%

Enhanced Depth Imaging Optical Coherence Tomography: A New Way Measuring Choroidal Thickness in Pregnant Women

Zhang

Wang

et al. 2017

Journal of Ophthalmology

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The body changes markedly during pregnancy; each system behaves differently from a nonpregnant state. As the eyes are the only windows to see directly what is going on in the internal environment, more and more researches have been done to explain the association between ocular changes and the physiological and pathological changes during pregnancy. The choroid is one of the critical parts of the eye, providing nutrition. And abnormal choroid may result in ocular dysfunction and visual problems. As the optical coherence tomography develops, a rapid, direct, noninvasive, and nontoxic way is available to obtain the choroid situation of pregnant women, which may explain the mechanism of pregnancy-related eye diseases. This review would summarize relevant original articles published from January 1, 2008 to December 1, 2016 to assess the changes of choroidal thickness (CT) with enhanced depth imaging optical coherence tomography (EDI-OCT) during pregnancy. And the relationship between choroidal thickness changes and pregnancy remains uncertain. To our knowledge, this is the first review of EDI-OCT in assessing the choroidal thickness of the pregnant women.

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Changes in choroidal thickness during pregnancy detected by enhanced depth imaging optical coherence tomography

Abstract: Choroidal thickness was found to be significantly decreased in healthy pregnant women during the third trimester compared to the first trimester. This finding can provide valuable information when interpreting pregnancy related ocular disorders.

Cited by 37 publications

References 27 publications

Changes in Choroidal Thickness in and Outside the Macula After Hemodialysis in Patients With End-Stage Renal Disease

Changes in Choroidal Thickness in and Outside the Macula After Hemodialysis in Patients With End-Stage Renal Disease

Comparison of Choroidal Thickness in Preeclamptic, Healthy Pregnant, and Nonpregnant Women: A Systematic Review and Meta-Analysis

Enhanced Depth Imaging Optical Coherence Tomography: A New Way Measuring Choroidal Thickness in Pregnant Women

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