Changes in coagulability as measured by thrombelastography following surgery for proximal femoral fracture

Increased Risk of Stroke in the Year After a Hip Fracture

“…21 Recent studies found that systemic migration of emboli to the brain through intracardiac or extracardiac right to left shunts resulting in stroke is more common than thought earlier. 22,23 In addition, systemic hypercoagulative status is a documented complication after surgery for proximal femoral fracture, 24 which could trigger a stroke. Third, the hospitalization and surgery required for hip fracture treatment are inevitably associated with unfavorable physiological changes during anesthesia and surgical procedures, which could predispose these patients to cerebro-and cardiovascular events.…”

Cemented hemiarthroplasty in traumatic displaced femoral neck fractures and deep vein thrombosis: is there really a link?

“…Factors that reportedly contribute to this period of hypercoagulability are trauma at the initial injury, subsequent surgery, blood loss secondary to the fracture and at surgery, and fluid resuscitation before and after surgery. (13,14) Given these controversies, we reviewed and compared the incidence of DVT and progression to PE in cemented versus uncemented hemiarthroplasty in this population of patients predisposed to hypercoagulability.…”

“…(11,12) Notably, all of these studies (6)(7)(8)(9)(10)(11)(12) used healthy patients for elective surgery, while patients with traumatic femoral neck fractures are potentially in a procoagulable state due to the nature of the trauma sustained in the initial injury. (13,14) In addition, several recent studies have reported on the possible thrombogenic properties of polymethyl methacrylate cement and the activation of platelet aggregation and cytokines, which could contribute to the pathogenesis of DVT. (15)(16)(17) With this background of controversy, we aimed to review and compare the incidence of DVT and its progression to pulmonary embolism (PE) or mortality in cemented versus uncemented hemiarthroplasty for traumatic displaced femoral neck fractures.…”

Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum: une étude observationnelle prospective exploratoire

“…It is uncertain whether TEG is sufficiently sensitive to detect subtle differences in the degree of maternal hypercoagulability. Although previous non-obstetric ); Non-AMA = no advanced maternal age (B 35 yr); r = reaction time; k = clot formation time; MA = maximum amplitude; G = shear modulus elastic strength; CL30 = clot lysis at 30 min after MA; MRTG = maximal rate of thrombus generation; TMRTG = time to maximum rate of thrombus generation; TTG = thrombus generation * n = 22 (1 analyzer error) n = 21 (2 analyzer errors) à n = 20 (1 patient refusal; 2 patients discharged before 72 hr) § n = 17 (1 patient discharged before 72 hr; 4 patients prescribed nonsteroidal anti-inflammatory drugs, and one patient prescribed enoxaparin at 72 hr) || P \ 0.05 for pre-Cesarean thromboelastography (TEG) variable vs 24 hr post-Cesarean TEG variable ** P \ 0.05 for 24 hr post-Cesarean TEG variable vs 72 hr post-Cesarean TEG variable studies have used TEG to detect a hypercoagulable state associated with venous thrombosis, [13][14][15] future populationwide studies incorporating more sensitive techniques are needed for a full evaluation of the potential associations between thrombin generation and platelet reactivity with postpartum VTE.…”

“…11,12 Furthermore, previous non-obstetric studies have reported that hypercoagulable states detected by TEG are associated with an increased risk of thrombotic complications, including myocardial infarction and thromboembolic events. [13][14][15] Nevertheless, these technologies have not been used to investigate whether differences exist in the maternal coagulation profile of AMA vs non-AMA women during the peripartum period.…”