Changes in cochlear electrical stimulation induced Fos expression in the rat inferior colliculus following deafness

Nagase, Shigeyo; Miller, Josef M.; Dupont, Jean‐Luc; Lim, Hyun–Ho; Sato, Kazuo; Altschuler, Richard A.

doi:10.1016/s0378-5955(00)00134-9

Cited by 26 publications

(20 citation statements)

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“…Compared with other animal models, cochlear implantation in the rat is considered surgically difficult, and while there are a number of acute studies in this species (Nagase et al, 2000;Wu et al, 2003;Hsu et al, 2001;Vischer et al, 1997;Paolini and Clark, 1998;Shepherd et al, 2004), there has been no chronic cochlear implantation reported. The reasons for this difficulty includes: i) relatively smaller size of the rat cochlea; ii) the difficulty in developing such a small multiple channel scala tympani electrode array; and iii) the presence of the stapedial or pterygopalatine artery (SA), located in the middle ear cavity (Govaerts et al, 1993;Judkins and Li, 1997;Praetorius et al, 2001;Pinilla et al, 2001;Yamamoto et al, 2003), severely reducing surgical access to the scala tympani.…”

Section: Introductionmentioning

confidence: 99%

Cochlear implantation in rats: A new surgical approach

Lü

Shepherd

2005

Hearing Research

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The laboratory rat has been used extensively in auditory research but has had limited use in cochlear implant related research due mainly to the surgically restricted access to the scala tympani. We have developed a new surgical method for cochlear implantation in rats. The key to this protocol was cauterizing the stapedial artery (SA) and making a small cochleostomy near the round window in order to enlarge the surgical access to the scala tympani. Five normal hearing Hooded Wistar rats were used to investigate the effect of cauterizing the SA on hearing and auditory nerve survival. Results showed that cauterizing the SA was surgically feasible, afforded excellent exposure of the round window niche for cochleostomy, and did not adversely affect acoustic thresholds measured electrophysiologically. Moreover, there was no difference in spiral ganglion cell densities for any cochlear turn when compared with the contralateral control ears. Three deafened rats were subsequently implanted with a scala tympani electrode array using this new surgical approach. Electrically evoked auditory brainstem responses using bipolar stimulation, and subsequent cochlear histopathology demonstrated that the cochlear implantation using a custom-made rat electrode array was safe and effective. The surgical approach presented in this paper presents a safe and effective procedure for acute or chronic cochlear implantation in the rat model.

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Section: Introductionmentioning

confidence: 99%

Cochlear implantation in rats: A new surgical approach

Lü

Shepherd

2005

Hearing Research

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“…By restoring auditory input to the brain, cochlear implants (CIs) induce changes in cerebral function that affect neural structures ranging from cochlear nuclei [Lustig et al, 1994] to extra-auditory cortical territories [Giraud et al, 2001a, b], and that involve all levels of neural organisation from intracellular components [Nagase et al, 2000] to large-scale cortical networks [Naito et al, 2000]. Depending on whether subjects have acquired auditory language prior to deafness or not, implantation corresponds to the discovery of a new sensory modality that minimally interferes with language, or to the restoration of a sense that is essential for communication.…”

Section: Introductionmentioning

confidence: 99%

Imaging Plasticity in Cochlear Implant Patients

Giraud

Truy

Frackowiak³

2001

Audiol Neurotol

105

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Auditory re-afferentation by cochlear implants (CI) offers a unique opportunity to study directly from within the auditory modality plastic changes taking place at organisational levels up to the supra- or polymodal level. These plastic changes resulting from deafness and chronic electrical stimulation can be studied using modern neuroimaging techniques. In this paper, we review the available techniques and the experimental approaches to human studies of plasticity, we discuss the different forms of plasticity that are associated with cochlear implantation and we point to the interest of imaging studies for providing a prognosis of functional outcome after implantation.

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“…Thus, there is a resulting influence on the balance between excitation and inhibition reflected in changes in neuronal response profiles (Bledsoe et al, 1995;Caspary et al, 1995;Francis and Manis, 2000;Kaltenbach and Afman, 2000;Mossop et al, 2000;Salvi et al, 2000;Syka and Rybalko, 2000) as well as in changes in tonotopic maps (Willott et al, 1982(Willott et al, , 1993Robertson and Irvine, 1989;Schwartz et al, 1993;Rajan and Irvine, 1998;Salvi et al, 1999;Nagase et al, 2000). A shift towards decreased inhibition and increased excitation has been reported in the CIC (Vale and Sanes, 2002) associated with decreases in GABA release (Bledsoe et al, 1995) and decreases in the GABA synthesizing enzyme GAD (Mossop et al, 2000).…”

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confidence: 99%

Changes in glycine immunoreactivity in the rat superior olivary complex following deafness

et al. 2005

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The balance between inhibitory and excitatory amino acid neurotransmitters contributes to the control of normal functioning of the auditory brainstem. Changes in the level of neuronal activity within the auditory brainstem pathways influence the balance between inhibition and excitation. Activity-dependent plasticity in the auditory pathways can be studied by creating a large decrease in activity through peripheral deafening. Deafness-related decreases in GABA have previously been shown in the inferior colliculus. However, glycine is a more prevalent inhibitory transmitter in the mature superior olivary complex (SOC). The present study therefore examined if there were deafness-related changes in glycine in the SOC using postembedding immunocytochemistry. Animals were bilaterally deafened by an intrascalar injection of neomycin. Five nuclei in the SOC, the lateral superior olive (LSO), superior paraolivary nucleus (SPoN), and the medial, lateral, and ventral nuclei of the trapezoid body (MNTB, LNTB, and VNTB) were examined 14 days following the deafening and compared to normal hearing age-matched controls. The LSO and SPoN were divided into high and low frequency regions. The number of glycine immunoreactive puncta on the somata of principal cells showed significant decreases in all regions assessed, with changes ranging from 50% in the VNTB to 23% in the LSO. J. Comp. Neurol. 494:179-189, 2006. Indexing termsauditory; brainstem; neomycin; superior olivary complex Increases or decreases in activity induce plastic changes in the mature auditory pathways (recently reviewed by Syka, 2002; and more generally by Møller 2001, 2005). There is deafness-associated plasticity at the synaptic level in the mature auditory brainstem, with HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript changes in amino acid neurotransmitters and receptors (Bledsoe et al., 1995;Potashner et al., 1997Potashner et al., , 2000Milbrandt et al., 1997;Ryugo et al., 1998;Caspary et al., 1999;Helfert et al., 1999;Mossop et al., 2000;Nakagawa et al., 2000; Sato et al., 2000a,b;Holt et al., 2005), in ion channels (Macica et al., 2003;Lu et al., 2004;von Hehn et al., 2004), as well as in synapse-related proteins such as protein kinases, Gap43, calbindin, ERK, SAPK, NT3 and BDNF (Idrizbegovic et al., 1998;Garcia et al., 2000;Illing and Michler, 2001; Suneja and Potashner, 2003b). Thus, there is a resulting influence on the balance between excitation and inhibition reflected in changes in neuronal response profiles (Bledsoe et al., 1995;Caspary et al., 1995;Francis and Manis, 2000;Kaltenbach and Afman, 2000;Mossop et al., 2000;Salvi et al., 2000;Syka and Rybalko, 2000) as well as in changes in tonotopic maps (Willott et al., 1982(Willott et al., , 1993Robertson and Irvine, 1989;Schwartz et al., 1993;Rajan and Irvine, 1998;Salvi et al., 1999;Nagase et al., 2000). A shift towards decreased inhibition and increased excitation has been reported in the CIC (Vale and Sanes, 2002) associated with decreases in GAB...

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Changes in cochlear electrical stimulation induced Fos expression in the rat inferior colliculus following deafness

Cited by 26 publications

References 53 publications

Cochlear implantation in rats: A new surgical approach

Cochlear implantation in rats: A new surgical approach

Imaging Plasticity in Cochlear Implant Patients

Changes in glycine immunoreactivity in the rat superior olivary complex following deafness

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