Changes in colorectal cancer incidence and mortality trends in Spain

López‐Abente, Gonzalo; Ardanáz, Eva; Torrella-Ramos, A.; Mateos, Antonio Navareño; Delgado-Sanz, Concha; Chirlaque, María Dolores

doi:10.1093/annonc/mdq091

Cited by 71 publications

(48 citation statements)

References 22 publications

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“…3 CRC incidence in Spain was 60.8 for men and 33.8 for women, with an estimated mortality of 28.10 for men and 14.67 for women (per 100,000, age adjusted to the standard European population for the years 2000-2004). 4 The human body contains a vast number of microbes essential to its proper functioning. Moreover, the human colon microbiota is composed of 10 13 to 10 14 microorganisms, primarily bacteria.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain

Delgado²,

et al. 2015

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Colorectal cancer (CRC) is the third most common cancer in the world and the second leading cause of cancer deaths in the US and Spain. The molecular mechanisms involved in the etiology of CRC are not yet elucidated due in part to the complexity of the human gut microbiota. In this study, we compared the microbiome composition of 90 tumor and matching adjacent tissue (adjacent) from cohorts from the US and Spain by 16S rRNA amplicon sequencing in order to determine the impact of the geographic origin on the CRC microbiome. Data showed a significantly (P < 0.05) higher Phylogenetic Diversity ( Predicted metagenome functional content from 16S rRNA surveys showed that bacterial motility proteins and proteins involved in flagellar assembly were over represented in adjacent tissues of both cohorts, while pathways involved in fatty acid biosynthesis, the MAPK signaling pathway, and bacterial toxins were over represented in tumors. Our study suggests that microbiome compositional and functional dissimilarities by geographic location should be taken in consideration when approaching CRC therapeutic options.

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Section: Introductionmentioning

confidence: 99%

Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain

Delgado²,

et al. 2015

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“…In Spain, CRC is the most incident cancer when considering both sexes together. There is a marked geographic variation in CRC rates, with Catalonia being the region with the highest incidence of this tumour with an adjusted rate above the European average, particularly in men (2,3).…”

Section: Introductionmentioning

confidence: 99%

Colonoscopy quality assessment in a mass population screening programme based on faecal occult blood test

Binefa

García

Milà

et al. 2013

Rev. esp. enferm. dig.

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Background and aim: the success of colorectal cancer (CRC) screening programmes largely depends on the quality of the events, processes and outcomes and therefore, quality assurance of endoscopy is an essential component. The quality indicators for colonoscopy in a screening programme setting are different from those performed in symptomatic people. The objective of this study was to report the main quality indicators of colonoscopies performed after a positive faecal occult blood test (FOBT) in a CRC screening programme in Catalonia.Methods: the period of study includes three rounds of the CRC screening programme from June 2006 to July 2013. Two types of FOBT were used: a qualitative biochemical guaiac-based test (gFOBT) and a quantitative immunochemical test (FIT). Quality indicators analysed in this study were compared to recommended colonoscopy standards from the published guidelines.Results: during the study period, 1,806 colonoscopies were performed in 1,691 individuals with a positive FOBT. All indicators were within the standard except waiting time to colonoscopy. Caecal intubation rate was 95.6 % and adequate bowel cleansing 93.6 %. Adenoma detection rate was better using FIT than gFOBT, 30.7 and 3.8 per 1,000 screenees, respectively. Cancer detection rate was also greater using FIT. Nearly 62 % of cancers were diagnosed at an early stage. The overall complication rate was 10.7 ‰.Conclusion: although the majority of results reached the recommended standards, some areas have been identified for quality enhancement. Continuous monitoring of quality indicators is essential for improving the current effectiveness of CRC screening programmes.

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“…É um tumor que representa um desafio para os próximos anos, quando se trata de prevenção primária, de implementação de rastreio da população e planejamento de assistência oncológica (LOPEZ-ABENTE et al, 2010).…”

Section: Discussionunclassified

Análise do perfil epidemiológico e sobrevida de pacientes com câncer colorretal em um hospital universitário de 2000 a 2010

Carvalho¹

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Changes in colorectal cancer incidence and mortality trends in Spain

Cited by 71 publications

References 22 publications

Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain

Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain

Colonoscopy quality assessment in a mass population screening programme based on faecal occult blood test

Análise do perfil epidemiológico e sobrevida de pacientes com câncer colorretal em um hospital universitário de 2000 a 2010

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