Changes in corneal endothelial cell density after initial Ex-PRESS drainage device implantation and its relating factors over 3 years

Aoyama, Yurika; Sakata, Rei; Fujishiro, Takashi; Honjo, Megumi; Shirato, Shiroaki; Aihara, Makoto

doi:10.1038/s41433-021-01888-1

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Aoyama et al reported that at 3 years after patients with POAG underwent Ex-Press surgery, their mean CED had decreased by 5.4% [12]. Our present nding is comparable.…”

Section: Discussionsupporting

confidence: 79%

Comparison of corneal endothelial cell density reduction between primary open angle glaucoma and pseudo-exfoliation glaucoma patients at 3 years after Ex-Press® surgery

Yamazaki,

Tojo,

Otsuka

et al. 2024

Preprint

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Purpose We compared corneal endothelial cell (CED) loss between primary open angle glaucoma (POAG) and pseudo-exfoliation glaucoma (PEX) after Ex-Press (EXP) surgery. Patients and Methods: This was a single-facility retrospective study. We included patients who had undergone EXP surgery and were followed up > 3 years. We measured the CED before and after EXP surgery by noncontact specular microscopy. We measured the CED at baseline and 12, 24, and 36 months post-surgery and compared the means of the CED values and CED survival ratios after EXP surgery by paired t-test. Results We included 119 eyes that underwent EXP surgery: POAG group, n = 60 eyes; PEX group, n = 59 eyes. In the POAG group, the mean CED decreased from 2389 ± 321 at baseline to 2230 ± 424 cells/mm2 after 3 years. In the PEX group, the mean CED decreased from 2111 ± 510 at baseline to 1845 ± 628 cells/mm2 after 3 years. After the 3-year follow-up, the CED survival ratio was 93.3 ± 12.5% in the POAG group and significantly lower at 85.0 ± 19.5% in the PEX group (p = 0.0064). Two cases in the PEX group developed bullous keratopathy. Conclusions Compared to POAG, EXP surgery for PEX patients decreased their corneal endothelial cells faster.

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“…Aoyama et al reported that at 3 years after patients with POAG underwent Ex-Press surgery, their mean CED had decreased by 5.4% [12]. Our present nding is comparable.…”

Section: Discussionsupporting

confidence: 79%

Comparison of corneal endothelial cell density reduction between primary open angle glaucoma and pseudo-exfoliation glaucoma patients at 3 years after Ex-Press® surgery

Yamazaki,

Tojo,

Otsuka

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In our study, the decrease was 15.1% in the corneal insertion group and 4.2% in the TM insertion group. Aoyama et al reported that EXP decreased ECD by 1.8%/year after 3 years[14]. Our 5-year result was 2.2%/year in the TM insertion group.This study does not compare ECD loss between EXP and Trab.…”

mentioning

confidence: 39%

Corneal endothelial cell loss after EX-PRESS surgery depends on site of insertion, cornea or trabecular meshwork

2023

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Previously, we reported that the Ex-press® shunt (EXP) was associated with more rapid reduction of corneal endothelial cells when inserted into the cornea rather than the trabecular meshwork (TM). We compared the reduction rate of corneal endothelial cells between the corneal insertion group and TM insertion group. MethodsThis was a retrospective study. We included patients who had undergone EXP surgery and were followed for > 5 years. We analyzed the corneal endothelial cell density (ECD) before and after EXP implantation. ResultsWe included 25 patients in the corneal insertion group and 53 patients in the TM insertion group. One patient in the corneal insertion group developed bullous keratopathy. The ECD decreased signi cantly more rapidly in the corneal insertion group (p < 0.0001), in whom the mean ECD decreased from 2227 ± 443 to 1415 ± 573 cells/mm 2 at 5 years with a mean 5-year survival rate of 64.9 ± 21.9%. By contrast, in the TM insertion group, the mean ECD decreased from 2356 ± 364 to 2124 ± 579 cells/mm 2 at 5 years, and the mean 5-year survival rate was 89.3 ± 18.0%. The decrease rate of ECD was calculated as 8.3%/year in the corneal insertion group and 2.2%/year in the TM insertion group. ConclusionsInsertion into cornea is a risk factor for rapid ECD loss. The EXP should be inserted into the TM to preserve the corneal endothelial cells.

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Comparison of corneal endothelial cell density reduction between primary open-angle glaucoma and pseudo-exfoliation glaucoma patients at 3 years after Ex-Press® surgery

Yamazaki,

Tojo,

Otsuka

et al. 2024

Int Ophthalmol

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We compared corneal endothelial cell (CED) loss between primary open angle glaucoma (POAG) and pseudo-exfoliation glaucoma (PEX) after Ex-Press (EXP) surgery. Patients and Methods:This was a single-facility retrospective study. We included patients who had undergone EXP surgery and were followed up > 3 years. We measured the CED before and after EXP surgery by noncontact specular microscopy. We measured the CED at baseline and 12, 24, and 36 months post-surgery and compared the means of the CED values and CED survival ratios after EXP surgery by paired t-test. ResultsWe included 119 eyes that underwent EXP surgery: POAG group, n = 60 eyes; PEX group, n = 59 eyes. In the POAG group, the mean CED decreased from 2389 ± 321 at baseline to 2230 ± 424 cells/mm 2 after 3 years. In the PEX group, the mean CED decreased from 2111 ± 510 at baseline to 1845 ± 628 cells/mm 2 after 3 years. After the 3-year follow-up, the CED survival ratio was 93.3 ± 12.5% in the POAG group and signi cantly lower at 85.0 ± 19.5% in the PEX group (p = 0.0064). Two cases in the PEX group developed bullous keratopathy. ConclusionsCompared to POAG, EXP surgery for PEX patients decreased their corneal endothelial cells faster.

show abstract

Changes in corneal endothelial cell density after initial Ex-PRESS drainage device implantation and its relating factors over 3 years

Cited by 5 publications

References 28 publications

Comparison of corneal endothelial cell density reduction between primary open angle glaucoma and pseudo-exfoliation glaucoma patients at 3 years after Ex-Press® surgery

Comparison of corneal endothelial cell density reduction between primary open angle glaucoma and pseudo-exfoliation glaucoma patients at 3 years after Ex-Press® surgery

Corneal endothelial cell loss after EX-PRESS surgery depends on site of insertion, cornea or trabecular meshwork

Comparison of corneal endothelial cell density reduction between primary open-angle glaucoma and pseudo-exfoliation glaucoma patients at 3 years after Ex-Press® surgery

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