Changes in Corneal Sensation and Ocular Surface in Patients With Asymmetrical Keratoconus

Abstract

The corneal sensitivity and ocular surface changes were significant in the subclinical KC and KC eyes compared with the control subjects. Ocular surface disease in KC was characterized by tear deficiency disorder and abnormal impression cytology results. However, no significant difference in tear osmolarity was found among the groups. The decrease in corneal sensitivity and ocular surface change may be associated with the pathogenesis of ocular surface changes in KC and the progression of the disease.

Evaluation of Subbasal Nerve Morphology and Corneal Sensation after Accelerated Corneal Collagen Cross-linking Treatment on Keratoconus

“…So, the low levels of the corneal sensitivity in some of our patients on preoperative period can be explained with these findings. 21 Mocan et al and Ozgurhan et al were also reported the similar mean corneal sensitivity range with our study at the patients with keratoconus that have decreased the subbasal nerve fiber density. [20][21][22] Mastropasqua et al 23 reported the traditional CXL-induced marked corneal modifications, which were poorly evident in the transepithelial method.…”

Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study

“…Our results showed a reduction in goblet cell density in KC patients, confirming results of several previous studies. 3,37,38 Furthermore, KC goblet cells produced less mucin, i.e. a lower CLT, thus secreting less mucin into the tears, i.e.…”

Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review

“…12 Indeed, keratoconic eyes have a damaged ocular surface suffering from the consequences of inadequate tear and mucin production, as well as aberrant antioxidant status and proteome alterations that affect tear fluid stability and quality. [93][94][95][96][97] Thus, the affected ocular M A N U S C R I P T…”