Changes in cytomegalovirus‐specific T‐cell immunity with immunomodulation in serodiscordant high‐risk transplant recipients

Abstract

To the Editor, Cytomegalovirus (CMV) infections cause significant morbidity and mortality among all solid organ transplant recipients. CMV discordant (D+/R−) recipients are at higher risk of developing CMV viremia after cessation of prophylaxis. 1 CMV-specific T-cell-mediated immunity (CMI) has been shown in previous studies to predict those at the highest risk for CMV-associated events. 2-4 However, it is unknown if changes in maintenance immunosuppression guided by CMI may lead to fewer CMV events as a result of improved immunity.