Changes in dendritic arborization related to the estrous cycle in pyramidal neurons of layer V of the motor cortex

Fernández-Castillo, S.; Silva-Gómez, Adriana B.

doi:10.1016/j.jchemneu.2021.102042

Cited by 2 publications

(2 citation statements)

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“…The estrous cycle is not determined in female mice. Previous studies suggest that spine density on the mPFC pyramidal neurons is stable throughout the estrous cycle in female mice [37][38][39][40][41]. However, we cannot completely exclude the possible role of the estrous cycle in spine density changes on PrL layer II/III pyramidal neurons.…”

Section: Resultsmentioning

confidence: 63%

“…Spine density on layer 5 pyramidal neurons of the mouse somatosensory cortex is stable throughout the estrous cycle [37,38]. In addition, spine density on layer 3 pyramidal neurons of the neocortex [39], and layer 5 pyramidal neurons of both the mPFC [40] and the motor cortex [41] does not change during the estrous cycle in rats. These results suggest that the spine density of the mPFC pyramidal neurons in female mice is stable during the estrous cycle.…”

Section: Determination Of the Estrous Cyclementioning

confidence: 98%

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Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice

Li,

Tan,

et al. 2024

Mol Psychiatry

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions, communication deficits and repetitive behaviors. A study of autistic human subjects has identified RFWD2 as a susceptibility gene for autism, and autistic patients have 3 copies of the RFWD2 gene. The role of RFWD2 as an E3 ligase in neuronal functions, and its contribution to the pathophysiology of ASD, remain unknown. We generated RFWD2 knockin mice to model the human autistic condition of high gene dosage of RFWD2. We found that heterozygous knockin (Rfwd2+/−) male mice exhibited the core symptoms of autism. Rfwd2+/− male mice showed deficits in social interaction and communication, increased repetitive and anxiety-like behavior, and spatial memory deficits, whereas Rfwd2+/− female mice showed subtle deficits in social communication and spatial memory but were normal in anxiety-like, repetitive, and social behaviors. These autistic-like behaviors in males were accompanied by a reduction in dendritic spine density and abnormal synaptic function on layer II/III pyramidal neurons in the prelimbic area of the medial prefrontal cortex (mPFC), as well as decreased expression of synaptic proteins. Impaired social behaviors in Rfwd2+/− male mice were rescued by the expression of ETV5, one of the major substrates of RFWD2, in the mPFC. These findings indicate an important role of RFWD2 in the pathogenesis of autism.

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