Abstract:We previously established an animal model of Parkinson's disease (PD) induced by chronic low-dose rotenone as an environmental neurotoxic pesticide that reproducible central and enteric neurodegenerative features of PD, and also found that rotenone-induced enteric neurodegeneration is caused by dysfunction of enteric glia using primary cultured enteric cells. However, the mechanism of enteric neurodegeneration and inflammation are still obscure. In this study, we examined changes in enteric cellular environmen… Show more
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