Changes in enzyme activity (glutamic-oxalacetic transaminase, lactic dehydrogenase, cytochrome c and cytochrome oxidase) in serum and heart muscle after experimental myocardial infarction

Trace Elements in Human Myocardial Infarction Determined by Neutron Activation Analysis

“…The serum Zn concentration, however, has been reported both as elevated (55,56) and as reduced (1 1, 12) in patients with myocardial infarction. An elevated Cu concentration has been reported in the serum of patients with myocardial infarction (1,18,52), and a reduced activity of cytochrome oxidase, a Cu enzyme, has been demonstrated in the infarcted rat and dog heart (2,39). I n the present investigation, however, no significant difference was found between the Cu content of injured and uninjured heart tissue.…”

“…However, the two cases with the earliest infarctions did, in fact, have an increased amount of Zn in the injured tissue. A reduction of Zn in injured tissue is in agreement with the fact that lactic dehydrogenase, a Zn enzyme, disappears from infarcted heart tissue (2,39). An increase in lactic dehydrogenase activity in the serum of patients with myocardial infarction is well documented, and is used in the diagnosis of this disease (6, 59).…”

“…Some Fe enzymes have also been stated to decrease in infarcted heart tissue. Thus, the content (4,5,8) and the activity (39) of cytochrome c and the activity of succinic dehydrogenase (2,39,54) have been reported as decreased in infarcted myocardium compared with uninjured. Moreover, a def-inite but inconstant decrease in Fe has been reported in the serum of patients with myocardial infarction (18).…”

Studies on Isocitric and Lactic Dehydrogenases in Experimental Myocardial Infarction*†

“…Several rabbits were studied to determine the normal Table I and Figure 2 record the data obtained onstrated that pentobarbital sodium anesthesia has no effect on serum enzyme activity (22). We observed increases in both ICD and LDH activity following thoracotomy; however, the increased activity of both these enzymes was similar in vena cava and coronary sinus samples.…”