Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients

Fujimoto, Toshiro; Okumura, Eiichi; Takeuchi, Kouzou; Kodabashi, Atsushi; Tanaka, Hiroki; Otsubo, Toshiaki; Nakamura, Katsumi; Shimizu, Masaki; Kamiya, Shinichiro; Higashi, Yuji; Tsuji, Miwa; Shimooki, Susumu; Tamura, Toshiyo

doi:10.2174/1874440001206010026

Cited by 18 publications

(14 citation statements)

References 72 publications

(74 reference statements)

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“…The temporal lobe plays a central role in many symptoms associated with schizophrenia, including altered cognitive function, oversensitization to sensory stimuli, and auditory hallucinations (Boyer et al, 2007; Brady et al, 2010; Bruder et al, 1999; Fujimoto et al, 2012). Structural and functional abnormalities of STG and hippocampus have been reported in this illness, while quantitative investigations have demonstrated reductions in neuronal size, cortical glial cell number, as well as changes in neuronal density (Boyer et al, 2007; Bruder et al, 1999; Heckers, 2001; Rajarethinam et al, 2004; Rajarethinam et al, 2000; Steen et al, 2006); (Benes et al, 1991; Cotter et al, 2002; Heckers and Konradi, 2002; Uranova et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia

Shan

Lucas

Drummond

et al. 2013

Schizophrenia Research

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Glutamate transporters facilitate the buffering, clearance and cycling of glutmate and play an important role in maintaining synaptic and extrasynaptic glutamate levels. Alterations in glutamate transporter expression may lead to abnormal glutamate neurotransmission contributing to the pathophysiology of schizophrenia. In addition, alterations in the architecture of the superior temporal gyrus and hippocampus have been implicated in this illness, suggesting that synapses in these regions may be remodeled from a lifetime of severe mental illness and antipsychotic treatment. Thus, we hypothesize that glutamate neurotransmission may be abnormal in the superior temporal gyrus and hippocampus in schizophrenia. To test this hypothesis, we examined protein expression of excitatory amino acid transporter 1-3 and vesicular glutamate transporter 1 and 2 in subjects with schizophrenia (n = 23) and a comparison group (n = 27). We found decreased expression of EAAT1 and EAAT2 protein in the superior temporal gyrus, and decreased EAAT2 protein in the hippocampus in schizophrenia. We didn’t find any changes in expression of the neuronal transporter EAAT3 or the presynaptic vesicular glutamate transporters VGLUT1-2. In addition, we did not detect an effect of antipsychotic medication on expression of EAAT1 and EAAT2 proteins in the temporal association cortex or hippocampus in rats treated with haloperidol for 9 months. Our findings suggest that buffering and reuptake, but not presynaptic release, of glutamate is altered in glutamate synapses in the temporal lobe in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia

Shan

Lucas

Drummond

et al. 2013

Schizophrenia Research

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“…Interestingly, while abnormalities of oscillations in schizophrenia have been observed across a wide range of frequencies [Doege et al, ; Fujimoto et al, ; Grutzner et al, ; Stephane et al, ; Uhlhaas and Singer, ], evidence implicates beta‐band abnormalities specifically in perceptual integration: Uhlhaas et al [] observed that deficits in Gestalt perception in schizophrenia were specifically associated with reduced beta‐band phase synchrony between spatially remote sites, while Sun et al [] using a similar perceptual task, showed reduced correlation between beta‐band oscillations and high gamma band activity in first episode cases of schizophrenia relative to controls.…”

Section: Introductionmentioning

confidence: 99%

Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations

Liddle

Price

Palaniyappan

et al. 2016

Human Brain Mapping

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Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, exaggerating the significance of everyday occurrences and thus leading to perceptual distortions and delusional causal inferences. Meanwhile, abnormalities in key nodes of a salience brain network have been implicated in other characteristic symptoms, including the disorganization and impoverishment of mental activity. A substantial body of literature reports disruption to brain network connectivity in schizophrenia. Electrical oscillations likely play a key role in the coordination of brain activity at spatially remote sites, and evidence implicates beta band oscillations in long‐range integrative processes. We used magnetoencephalography and a task designed to disambiguate responses to relevant from irrelevant stimuli to investigate beta oscillations in nodes of a network implicated in salience detection and previously shown to be structurally and functionally abnormal in schizophrenia. Healthy participants, as expected, produced an enhanced beta synchronization to behaviorally relevant, as compared to irrelevant, stimuli, while patients with schizophrenia showed the reverse pattern: a greater beta synchronization in response to irrelevant than to relevant stimuli. These findings not only support both the aberrant salience and disconnectivity hypotheses, but indicate a common mechanism that allows us to integrate them into a single framework for understanding schizophrenia in terms of disrupted recruitment of contextually appropriate brain networks. Hum Brain Mapp 37:1361‐1374, 2016. © 2016 Wiley Periodicals, Inc.

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“…Many studies have shown structural and functional abnormalities in temporal lobe brain regions in schizophrenia [13,58,64,65]. Schizophrenia patients showed smaller anterior, but not posterior, hippocampal volumes, and larger P50 and M50 gating ratios than controls [66].…”

Section: Discussionmentioning

confidence: 99%

“…Disturbances in oscillations in high gamma bands in this study may be related to cross-frequency coupling between gamma and theta oscillation. We reported that the ERS power in the theta band (4–8 Hz) during the oddball task in the schizophrenia patient group was significantly increased in the left temporal pole at 250–500 ms, and was significantly increased in the dorsal and medial frontal and anterior portions of the anterior cingulate cortex in both hemispheres, and the left lateral temporal regions at 500–750 ms, compared to the control group [13]. Dysfunction in the gamma band in schizophrenia, probably due to cross-frequency coupling, may reflect disturbances in the encoding of new information related to the hippocampal theta rhythm induced in the cortex via hippocampo-cortical feedback loops or vice versa.…”

Section: Discussionmentioning

confidence: 99%

“…Reduction of P300 amplitude in ERP (event related potential) study during the oddball task is one of the most replicable biological observations in patients with schizophrenia [1-13]. We therefore investigated gamma band activity in the P300 ERP component during the classical odd ball task, using electroencephalography (EEG) and magnetoencephalography (MEG) in male schizophrenia patients by reciprocal cortico-cortical connections [14].…”

Section: Introductionmentioning

confidence: 99%

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Dysfunctional Cortical Connectivity During the Auditory Oddball Task in Patients with Schizophrenia

Fujimoto¹,

Okumura²,

Takeuchi³

et al. 2013

Open Neuroimag J

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Background:We studied the imaginary coherence (IC) of gamma frequency oscillations between brain regions of male schizophrenia patients during an auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG).Methods:Subjects were 10 right-handed male schizophrenia patients, evaluated by the positive and negative symptom scale (PANSS), and 10 healthy controls. Functional connectivity during the auditory oddball task was reconstructed in low (30-50 Hz) and high (50-100 Hz) gamma bands, and represented by imaginary coherence (IC) based on significant oscillatory power changes. We calculated correlations between PANSS scores and IC.Results:In the high gamma band, IC between left occipital and right prefrontal lobe areas during the time window 750-1000 ms from stimulus onset showed negative correlations with total negative scores, total positive scores, the sum of positive and negative scores in PANSS, conceptual disorganization, and social avoidance scores. In the low gamma band, IC between the same areas from 250-500 ms also showed a negative correlation with the conceptual disorganization score. In the same time window, IC between left occipital and right frontoparietal lobe areas in the low gamma band showed a positive correlation with hallucinatory behavior; IC between right temporal pole and left prefrontal lobe areas showed a positive correlation with delusion scores, although these ICs were decreased relative to controls.Conclusions:Functional disconnection of high and low gamma bands in auditory oddball task may play an important role in the auditory processing in schizophrenia patients.

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Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients

Cited by 18 publications

References 72 publications

Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia

Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia

Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations

Dysfunctional Cortical Connectivity During the Auditory Oddball Task in Patients with Schizophrenia

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