Changes in Externalizing Behaviors After Children First Have an Alcoholic Drink and First Drink Heavily

Staff, Jeremy; Maggs, Jennifer L.; Bucci, Rebecca; Mongilio, Jessica

doi:10.15288/jsad.2019.80.472

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…initiation, consumption, problematic use; Chassin, Pitts, & Prost, 2002;Defoe, Khurana, Betancourt, Hurt, & Romer, 2022;Elkins, King, McGue, & Iacono, 2006;Farmer et al, 2016;Fergusson, Horwood, & Ridder, 2007;King, Iacono, & McGue, 2004;Kuperman et al, 2013;Quinn & Harden, 2013;Stautz & Cooper, 2013;Wright & Jackson, 2023), in line with neurodevelopmental theories that impulsivity poses vulnerability to the initial seeking and rewarding aspects of alcohol use. A smaller body of work in large, prospective samples of youth and young adults suggests that alcohol use may be linked with increases in impulsive and externalizing phenotypes, possibly reflecting alcohol-induced neurocognitive impairment, reward learning, and/or shared genetic predisposition, consistent with the neurobiological stage-based model (Quinn, Stappenbeck, & Fromme, 2011;Staff, Maggs, Bucci, & Mongilio, 2019).…”

Section: Bidirectional Associations Between Behavior and Alcohol Invo...mentioning

confidence: 89%

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations

Paul,

Baranger,

Johnson

et al. 2024

Psychol. Med.

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Background Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk. Methods Data came from the Collaborative Study on the Genetics of Alcoholism (n = 3681; ages 11–36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones. Results Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). Problematic alcohol use PGS increased hazards for suicidal ideation (HR = 1.20). Conclusions Behavioral markers of addiction vulnerability precede and follow alcohol transitions, highlighting dynamic, bidirectional relationships between behavior and emerging addiction.

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Section: Bidirectional Associations Between Behavior and Alcohol Invo...mentioning

confidence: 89%

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations

Paul,

Baranger,

Johnson

et al. 2024

Psychol. Med.

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“…All multiple imputations were run using the "mi estimate" command in Stata 15 (StataCorp 2017). Previous studies have used multiple imputations with the MCS data and retained accurate estimates (Staff et al 2019).…”

Section: Analytic Strategymentioning

confidence: 99%

Childhood Head Injury as an Acquired Neuropsychological Risk Factor for Adolescent Delinquency

Mongilio

2022

Journal of Research in Crime and Delinquency

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Objectives This study aims to parse out the effects of childhood head injury (HI) as an acquired neuropsychological deficit that impacts adolescent delinquent behavior, while accounting for other early-life risk factors and potential temporal ordering. Methods Nationally representative prospective data from the UK Millennium Cohort Study (MCS; N = 13,287) and a series of logistic and binomial regressions are used to examine the relationship between early-life risk factors, HI, and adolescent delinquent behavior. Methodological considerations from clinical HI research, such as the use of an orthopedic injury comparison group, are incorporated. Results Findings are consistent with the conceptualization of HI as an acquired neuropsychological deficit, in that childhood HI increases the risk of early- and adolescent-onset delinquency, sustained delinquent behavior from childhood to early adolescence, and participation in a greater variety of delinquent behavior. Conclusions Childhood HI is relatively common, as over 27% of the sample reported at least one HI. The importance of HI as an acquired neuropsychological deficit and its relevance as a risk factor for later criminal behavior is reiterated. Future research should examine the importance of developmental period effects and mechanisms underlying this relationship.

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Parents Allowing Drinking Is Associated With Adolescents’ Heavy Alcohol Use

Staff

Maggs

2019

Alcoholism Clin & Exp Res

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Background.-Using intergenerational prospective data from the Millennium Cohort Study (MCS), we examine whether parents allowing 14-year-olds to drink alcohol is associated with greater likelihood of early adolescents' heavy episodic drinking (i.e., lifetime, rapid escalation from first drink, and frequent past-year), beyond shared risk factors for parental alcohol permissiveness and adolescent alcohol use.Methods.-The MCS is a unique, contemporary, nationally-representative study with mother, father, and child data from infancy through age 14 years (n=11,485 children and their parents). In a series of multivariate logistic regressions, we estimated whether teenagers whose parents allowed them to drink alcohol (>1,700 parents said "yes") faced an elevated likelihood of heavy alcohol use at age 14, controlling for a large host of likely child and parent confounders measured when children were age 11. To further assess plausible intergenerational associations of parental alcohol permissiveness and offspring heavy alcohol use, Coarsened Exact Matching (CEM) was used to match 14-year-olds whose parents allowed them to drink alcohol with teens whose parents did not allow them to drink on these childhood antecedent variables.Results.-Adolescents whose parents allowed them to drink had higher odds of heavy drinking (Odds Ratio=2.40; 95% Confidence Interval=1.96 to 2.94), rapidly escalating from initiation to heavy drinking (OR=1.94; CI=1.52 to 2.49), and frequent heavy drinking (OR=2.32; 1.73 to 3.09), beyond child and parent confounders and using CEM methods.Conclusions.-Adolescents who were allowed to drink were more likely to have transitioned quickly from their first drink to consuming 5 or more drinks at one time and to drinking heavily 3 or more times in the past year. Given well-documented harms of adolescent heavy drinking, these results do not support the idea that parents allowing children to drink alcohol inoculates them against alcohol misuse.

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Changes in Externalizing Behaviors After Children First Have an Alcoholic Drink and First Drink Heavily

Cited by 3 publications

References 49 publications

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations

Childhood Head Injury as an Acquired Neuropsychological Risk Factor for Adolescent Delinquency

Parents Allowing Drinking Is Associated With Adolescents’ Heavy Alcohol Use

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