Table of contents Chapter Introduction and aims of thesis 7 Part I Tools and treatment for dumping syndrome-current state of affairs Chapter Diagnostic tools for post-gastric bypass hypoglycaemia 23 Chapter Dumping Syndrome: Pathophysiology, Diagnosis, and Management 49 Part II Improving understanding of dumping syndrome Chapter Short to mid-term symptom prevalence of dumping syndrome after primary gastric bypass surgery and its impact on health related quality of life. 81 Chapter Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a Mixed Meal Tolerance Test. 103 Chapter Prevalence of hypoglycaemia in a random population after Roux-en-Y gastric bypass during a meal test 119 Part III Solving old problems, creating new ones Chapter Conversion of failed laparoscopic adjustable gastric banding to Roux-en-Y gastric bypass is safe as a single step procedure 139 Chapter Long term self-reported symptom prevalence of early and late dumping in a patient population after sleeve gastrectomy, primary and revisional gastric-bypass surgery 153 Chapter Summary and future perspectives 169 Chapter Samenvatting, discussie van belangrijkste bevindingen en toekomstig onderzoek 185 Appendices List of publications 203 Dankwoord 207 Curriculum Vitea 213 Figure 6: Vertical Banded Gastroplasty by Mason 13 The AIm And OuTlIne OF ThIs ThesIs The general aim of this thesis is to summarize what is currently known about early and especially late dumping syndrome, and to improve our understanding of this disease, with the ultimate goal of providing additional practical information for both surgeon and patient regarding their prevalence, consequence and pathophysiology. This thesis is divided into three parts. Part I Tools and treatment for dumping syndrome-current state of affairs. Chapter 2 gives an overview of the literature of the diagnostic tools used to study or to establish the presence of late dumping. Chapter 3 describes the current knowledge of the pathophysiology of early and late dumping, and provides practical treatment advice. Part II Improving our understanding of dumping syndrome. Chapter 4 describes the short-to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery, and its impact on (health-related) quality of life when studied by means of patient questionnaires. Chapter 5 reports on the prevalence and pathophysiology of early dumping in a random selection of patients after undergoing a mixed meal tolerance test. Chapter 6 describes the results from chapter 5, focusing on late dumping. Part III solving old problems, creating new ones. Chapter 7 describes the results of conversion of failed laparoscopic adjustable gastric banding to Roux-en-Y gastric bypass, and provides information about its safety as a single-step procedure. Chapter 8 reveals that the conversion to Roux-en-Y gastric bypass after gastric banding has consequences with regard to late dumping. In this chapter results on self-reported symptom prevalence of dumping are given on pat...