Changes in fat mass and fat-free-mass are associated with incident hypertension in four population-based studies from Germany

Ittermann, Till; Werner, N.; Lieb, Wolfgang; Merz, Benedikt; Nöthlings, Ute; Kluttig, Alexander; Tiller, Daniel; Greiser, Karin Halina; Vogt, Susanne; Thorand, Barbara; Peters, Annette; Völzke, Henry; Dörr, Marcus; Schipf, Sabine; Markus, Marcello Ricardo Paulista

doi:10.1016/j.ijcard.2018.09.035

Cited by 12 publications

(10 citation statements)

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“…BMI is an independent risk factor for hypertension in both men and women, and high fat mass is associated with a higher risk of hypertension, even in non-obese populations [ 34 ]. In contrast, it has also been shown that a reduction in fat-free mass is more strongly associated with the normalization of blood pressure than a reduction in fat mass [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Long-term changes in body composition and their relationships with cardiometabolic risk factors: A population-based cohort study

et al. 2021

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The aim of the present study was to classify the latent body fat trajectories of Chinese adults and their relationships with cardiometabolic risk factors. Data were obtained from the China Health Nutrition Survey for 3,013 participants, who underwent six follow-up visits between 1993 and 2009. Skinfold thickness and other anthropometric indicators were used to estimate body composition. The latent growth model was used to create fat mass to fat-free mass ratio (F2FFMR) trajectory groups. Blood pressure, fasting plasma glucose, total cholesterol, triglycerides, and high- and low-density lipoprotein–cholesterol were measured in venous blood after an overnight fast. Logistic regression was used to explore the relationships of F2FFMR trajectory with cardiometabolic risk factors. In men, four types of F2FFMR trajectory were identified. After adjustment for behavioral and lifestyle factors, age, and weight status, and compared with the Low stability group, the High stability group showed a significant association with diabetes. In women, three types of F2FFMR trajectory were identified. Compared to the Low stability group, the High stability group showed significant associations with diabetes and hypertension after adjustment for the same covariates as in men. Thus, in this long-term study we have identified three F2FFMR trajectory groups in women and four in men. In both sexes, the highly stable F2FFMR is associated with the highest risk of developing diabetes, independent of age and body mass. In addition, in women, it is associated with the highest risk of hypertension, independent of age and body mass.

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Section: Discussionmentioning

confidence: 99%

Long-term changes in body composition and their relationships with cardiometabolic risk factors: A population-based cohort study

et al. 2021

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“…Changes in body composition characteristics and intrarenal dopamine are associated with hypertension [30,31]. Moreover, FFM, the more metabolically active body portion, has been reported to have a more predominant effect on the human brain [32].…”

Section: Discussionmentioning

confidence: 99%

Circulating Levels of the Heparan Sulfate Proteoglycan Syndecan-4 Positively Associate with Blood Pressure in Healthy Premenopausal Women

2021

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Syndecans (SDCs) are transmembrane proteins that are present on most cell types where they play a role in multiple physiological processes, including cell–matrix adhesion and inflammation. Growing evidence suggests that elevated levels of both shed SDC1 and SDC4 are associated with hypertension and cardiovascular diseases, but their relationships with cardiovascular risk factors in healthy individuals are unknown. The primary objective of this study was to investigate whether serum levels of SDC4 and SDC1 were associated with body composition, hemodynamic parameters, pro-inflammatory cytokine concentrations, and urinary noradrenaline and dopamine levels in healthy women (17 African American and 20 European American) between the ages of 20 and 40 years old. Univariate analyses revealed only a significant (p < 0.05) inverse correlation between serum SDC1 and body fat percentage. On the other hand, serum SDC4 was positively correlated with systolic blood pressure, diastolic blood pressure, and urinary levels of noradrenaline and dopamine. Serum SDC4 was also a significant predictor of systolic blood pressure in a multivariate regression model that included fat-free mass and urinary dopamine levels as significant independent variables. The result did not change even adjusting for race. Our findings indicate that SDC4 has an important role in the physiological regulation of blood pressure.

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“…However, a recent study has shown that a higher body fat percentage (BF%) is associated with an increased risk of hypertension, even in non-obese individuals (8). Furthermore, an increase in fat mass (FM) and fat-free mass (FFM) is associated with incident hypertension (9). These findings suggest that not only BMI but also differences in body composition are associated with hypertension.…”

Section: Introductionmentioning

confidence: 99%

Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study

Takase

Nakamura

Tsuchiya

et al. 2021

Clinical and Experimental Hypertension

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Background: A higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. Methods: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. Results: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. Conclusions: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.

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Changes in fat mass and fat-free-mass are associated with incident hypertension in four population-based studies from Germany

Cited by 12 publications

References 34 publications

Long-term changes in body composition and their relationships with cardiometabolic risk factors: A population-based cohort study

Long-term changes in body composition and their relationships with cardiometabolic risk factors: A population-based cohort study

Circulating Levels of the Heparan Sulfate Proteoglycan Syndecan-4 Positively Associate with Blood Pressure in Healthy Premenopausal Women

Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study

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