Changes in Fibrin-stabilizing Factor Levels in Relation to Maternal Hemorrhage and Neonatal Disease

Ambrus, Clara M.; Ambrus, Julian L.; Niswander, Kenneth R.; Weintraub, David H.; Bross, Irwin D. J.; Lassman, Howard B.

doi:10.1203/00006450-197001000-00010

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Sick Newborns1

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1970

1983

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Cited by 13 publications

(2 citation statements)

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“…It might be mentioned that Ambrus e t al. (1,2) suggested that there might be a relation between high levels of FSF and incidence of hyaline membrane in preterm babies. As seen in Table 1, our results t o date d o not seem t o bear out this conclusion.…”

Section: Sick Newbornsmentioning

confidence: 99%

Fibrin-stabilizing Factor (Factor XIII) in the Fetus and the Newborn Infant

et al. 1974

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Section: Sick Newbornsmentioning

confidence: 99%

Fibrin-stabilizing Factor (Factor XIII) in the Fetus and the Newborn Infant

et al. 1974

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“…Such haemorrhages may be fatal, especially in premature babies. The level of pulmonary plasminogen activator in the newborn is high (Ambrus et al, 1965) and this may account for the most severe haemorrhagic manifestations occurring in the lungs. Intracranial haemorrhages are most often initiated by vascular rupture but owing to the relatively poor coagulability of the blood in newborns, it might be wise to delay fibrinolysis, a measure proposed and used with some success in the treatment of subarachnoid haemorrhages (Mullan & Acta Obstet Gynec Scand 49 (1970) Dawley, 1968;NorlCn & Thulin, 1968).…”

Section: Results and Commentsmentioning

confidence: 99%

Human Placental Transfer of an Antifibrinolytic Agent (AMCA)

Kullander

Nilsson

1970

Acta Obstet Gynecol Scand

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A fibrinolytic inhibitor AMCA (trans p-aminomethyl cyclohexane carboxylic acid) was given i.v. in a dose of 0.01 g/kg bodyweight to 12 mothers about to be delivered by Caesarean section. Immediately after delivery the concentration of AMCA was determined in the maternal blood and in cord blood. AMCA was determined by a chemical method based on high voltage paper electrophoresis and photometric determination of the ninhydrin complex. It was found that AMCA passes through the placenta and that the concentration of the drug in the cord blood can be fairly high (4-31 ,ug per ml). The possible value of prophylaxis of the foetus with AMCA by the maternal route to check fibrinolytic bleedings (pulmonary or intracranial) sustained during premature delivery is discussed.

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Blood Coagulation Factors and Fibrinolysis

Reisman

1978

Perinatal Physiology

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Changes in Fibrin-stabilizing Factor Levels in Relation to Maternal Hemorrhage and Neonatal Disease

Cited by 13 publications

References 24 publications

Fibrin-stabilizing Factor (Factor XIII) in the Fetus and the Newborn Infant

Fibrin-stabilizing Factor (Factor XIII) in the Fetus and the Newborn Infant

Human Placental Transfer of an Antifibrinolytic Agent (AMCA)

Blood Coagulation Factors and Fibrinolysis

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