Changes in general and central fatness are associated with hepatocellular carcinoma: A Korean nationwide longitudinal study

Kim, Mi Na; Han, Kyungdo; Yoo, Juhwan; Ha, Yeonjung; Chon, Young Eun; Lee, Ju Ho; Hwang, Seong Gyu

doi:10.1002/ijc.33920

Cited by 1 publication

(2 citation statements)

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“…Instead, we defined significant liver fibrosis using the fibrotic marker, the BARD score. The well‐known fibrotic markers, FIB‐4 and APRI, 19 could not be calculated because platelet count data was not available in our cohort. Third, detailed data on viral factors, such as the viral load (HBV DNA and HCV RNA levels), duration of antiviral therapy, and virological response were not available for our cohort.…”

Section: Discussionmentioning

confidence: 99%

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Diabetic MAFLD is associated with increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis patients

Kim

Han

Yoo

et al. 2023

Intl Journal of Cancer

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Metabolic dysfunction‐associated fatty liver disease (MAFLD) can coexist with chronic viral hepatitis. MAFLD is a heterogeneous disease because the diagnostic criteria include various metabolic traits. We aimed to identify patients at high risk of poor long‐term outcomes based on MAFLD subgroups in chronic viral hepatitis patients. We evaluated 63 273 chronic hepatitis B and C patients. Patient with a fatty liver index ≥30 was defined to have hepatic steatosis. MAFLD was defined as the presence of hepatic steatosis with any one of the following three conditions, overweight/obesity, type 2 diabetes or ≥2 metabolic risk factors. The prevalence of MAFLD was 38.4% (n = 24 290). During a median 8.8‐year follow‐up, 1839 HCCs and 2258 deaths were documented in MAFLD patients. Among MAFLD patients, diabetes could identify patients at high risk of HCC and mortality, whereas overweight/obesity and metabolic risk factors did not. Compared with non‐MAFLD patients, risk of HCC and mortality was significantly higher in diabetic MAFLD patients (adjusted hazard ratio [aHR] = 1.34, 95% confidence interval [CI] = 1.26‐1.43 for HCC; aHR = 1.15, 95% CI = 1.08‐1.22 for mortality). Risk of HCC and mortality was significantly higher in diabetic MAFLD patients (aHR = 1.40, 95% CI = 1.26‐1.55 for HCC; aHR = 1.77, 95% CI = 1.63‐1.93 for mortality) compared with non‐diabetic MAFLD patients. Diabetic MAFLD is associated with increased risk of HCC and mortality among chronic viral hepatitis patients. Our findings highlight the need for close surveillance and effective treatment for these high‐risk patients to reduce HCC and mortality in patients with chronic viral hepatitis.

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Section: Discussionmentioning

confidence: 99%

“…An alanine aminotransferase (ALT) level ≤ 40 IU/L was considered normal 18 . Comorbidities including liver cirrhosis, diabetes, hypertension and dyslipidemia were defined using diagnostic codes and/or medication as a previous study 19 (Table S1).…”

Section: Methodsmentioning

confidence: 99%

Diabetic MAFLD is associated with increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis patients

Kim

Han

Yoo

et al. 2023

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

Changes in general and central fatness are associated with hepatocellular carcinoma: A Korean nationwide longitudinal study

Abstract: We investigated the impact of short-term changes in general and central fatness on the risk of hepatocellular carcinoma (HCC) in a large, population-based cohort. We screened 7 221 479 subjects who underwent health examinations provided by the

Cited by 1 publication

References 58 publications

Diabetic MAFLD is associated with increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis patients

Diabetic MAFLD is associated with increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis patients

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