Changes in glucose‐lipid metabolism, insulin resistance, and inflammatory factors in patients with autoimmune thyroid disease

Lei, Yi; Yang, Jun; Li, Hua; Zhong, Haihua; Wan, Qin

doi:10.1002/jcla.22929

Cited by 48 publications

(50 citation statements)

References 23 publications

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“…However, our study did not show a significant correlation between vitamin D and HT, so it can be seen that vitamin D may be reduced in HT, but lower vitamin D level is not a risk factor for HT, and it cannot cause an increase in its incidence. TSH is considered a potential stimulator of interleukin (IL)-6, IL-12, and tumor necrosis factor (TNF)-α in HT patients (17). Our study found that TSH was higher in the HT group, and according to the literature, TSH further promoted the release of inflammatory factors, suggesting that TSH may be associated with the occurrence of HT.…”

Section: Discussionsupporting

confidence: 66%

Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

2020

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The purpose of this study was to further clarify the association of Hashimoto's thyroiditis (HT) and vitamin D deficiency, and to seek the connection between them and related influencing factors. Methods: Data were obtained from subjects who underwent health examinations from January 2018 to December 2018. The diagnosis of HT was based on: antithyroid peroxidase antibody (TPO-Ab) levels >35 IU/ml and/or antithyroglobulin antibody (Tg-Ab) levels >40 IU/ml. Based on the Endocrine Society guidelines, 25-hydroxyvitamin D [25(OH)D] levels ≥30.0 ng/ml were classified as a vitamin D sufficiency; those between 20 and 29.9 ng/ml, as an insufficiency; and those <20 ng/ml, as a deficiency. All statistical analysis was performed by software R. Results: Of a total of 75,436 individuals who were physically examined, 5,656 of them had 25(OH)D levels tested at the same time; 5,230 were enrolled. The level of 25(OH)D in the non-HT group was higher than that in the HT group. Multiple regression analysis showed that HT was statistically significantly correlated with being male, body mass index (BMI), waist circumference, and thyroid-stimulating hormone (TSH). TSH levels in the insufficiency group and deficiency group were higher than those in the sufficiency group. Free triiodothyronine (FT3) and thyroxine (FT4) levels in the insufficiency group and deficiency group were lower than those in the sufficiency group. 25(OH)D increased by 1 ng/ml at the normal reference level, with an increase of 2.78 ng/dl in FT4 concentration and a decrease of 0.17 mIU/L in TSH. Conclusions: Patients with HT present with a reduced 25(OH)D level, and TSH is an independent risk factor for HT. TSH is negatively correlated with 25(OH)D level. FT3 and FT4 levels were positively correlated with 25(OH)D levels.

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Section: Discussionsupporting

confidence: 66%

Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

2020

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“…Thyroid autoantibodies were believed to have potential systemic functions ( 16 ). We observed significant decrease in MAFLD prevalence with the rise of serum TRAb and TgAb.…”

Section: Discussionmentioning

confidence: 99%

“…Both innate immunity ( 14 ) and adaptive immunity ( 15 ) contribute to the progression of MAFLD. In autoimmune thyroid diseases (AITD), thyroid autoantibodies not only cause damage to thyroid tissues, but may also have potential out-thyroid actions ( 16 ). Recently, studies have shown that the presence of thyroid antibodies are involved in glucose and lipid metabolic disorders ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Thyroid Hormones and Autoantibodies in Metabolic Dysfunction Associated Fatty Liver Disease: TgAb May Be a Potential Protective Factor

Zhang

Chen

et al. 2020

Front. Endocrinol.

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BackgroundPrevious studies have shown that metabolic dysfunction associated fatty liver disease (MAFLD) is associated with thyroid hormones (THs), immunity, and inflammation status, but few studies involved thyroid autoimmunity. This study aimed to evaluate the role of THs, thyroid autoantibodies, inflammatory biomarkers in MAFLD, its cofactors, and other possible determinants.Materials and MethodsIn the study, a total of 424 Chinese patients were selected and categorized as non-MAFLD and MAFLD. Serum thyroid hormone, thyroid autoantibody and high-sensitive C-reactive protein (hsCRP) levels were measured. The data of blood pressure, the serum lipid profile, glucose and liver enzymes were collected. The differences and association between research findings were examined and analyzed by Wilcoxon Signed Rank Test, One-Way ANOVA test and Multiple Logistic Regression models.ResultsThe study showed significant increase in the prevalence of MAFLD with high thyroid stimulating hormone (TSH) levels (P < 0.01) and abnormal high-sensitive C-reactive protein (hsCRP) levels (P < 0.01). The proportion of MAFLD patients decreased significantly with the rise of free thyroxine (FT4) (P = 0.04), thyrotropin receptor antibodies (TRAb) (P < 0.01), anti-thyroglobulin antibodies (TgAb) (P < 0.01), and thyroid peroxidase antibodies (TPOAb) levels (P < 0.01). Based on logistic regression analysis, MAFLD was significantly associated with lower levels of TgAb (P < 0.01), TPOAb (P < 0.01), and higher levels of hsCRP (P < 0.01) in male. In female, elevated TgAb (P < 0.01) may be a protective factor, while higher levels of hsCRP (P < 0.01) showed increased risk of MAFLD. Logistic models were adjusted for age, BMI, SBP, DBP, FBG, ALT, AST, TC, TG, LDL, HDL.ConclusionsTaken together, TgAb may be a potential protective factor for MAFLD and elevated hsCRP level should be considered as an independent risk factor for MAFLD in both genders. TPOAb also demonstrated protective effect, but only in male. The prevalence of MAFLD increased with higher TSH levels and lower FT4, TRAb levels, but no significant association were found. However, Our findings provide a new insight into the pathogenesis of MAFLD by further investigating the impact of THs, thyroid autoimmunity, and inflammation on MAFLD patients.

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“…They proved that TNF-α levels were higher for people with hypothyroidism compared to people with levelled thyroid hormones. Interestingly, this concentration showed a decreasing relationship for hypothyroidism and euthyreosis in the group of sick people and among healthy people [17]. Results from as early as the 1990s suggested that TNF-α is present in the thyroid tissue of its various diseases.…”

Section: Discussionmentioning

confidence: 98%

Level of selected pro-inflammatory markers in middle-aged women with Hashimoto’s disease

Szczepanik¹,

Graczyk²,

Domaszewska³

2020

jhi

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Introduction: Hashimoto's disease is an autoimmune disease in which the body produces antibodies against its own tissues, in this case against thyrocytes. Autoimmune diseases are associated with impaired immune tolerance. The aim of this study was to analyse selected pro-inflammatory markers in women with Hashimoto's (HT) autoimmune thyroiditis compared to a group of healthy women. Material and methods: In this research study 41 women with HT were compared with 30 healthy women. The content of immunological markers was assessed in blood serum by enzyme-linked ELISA methods. Cytokine IL-1ß, IL-6, and TNF-α were assessed. Results: The concentration of IL-1β for women with HT was 3.1 (1.8-4.9) pg/ml, and for healthy women 1.0 (0.1-1.9) pg/ml. The concentration of IL-6 for women with HT was 12.1 (6.7-19.4) pg/ml, and for healthy women 3.8 (2.5-6.7) pg/ml. TNF-α concentration was higher for people with HT, at 3.4 (2.0-4.4) pg/ml, compared to healthy women, who had a level of 2.2 (1.2-3.4) pg/ml), but without significant statistical differences. Conclusions: In HT we observe an increased immune response associated with an elevated concentration of pro-inflammatory cytokines.

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Changes in glucose‐lipid metabolism, insulin resistance, and inflammatory factors in patients with autoimmune thyroid disease

Cited by 48 publications

References 23 publications

Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

The Role of Thyroid Hormones and Autoantibodies in Metabolic Dysfunction Associated Fatty Liver Disease: TgAb May Be a Potential Protective Factor

Level of selected pro-inflammatory markers in middle-aged women with Hashimoto’s disease

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