Changes in glutamate decarboxylase enzyme activity and tau-protein phosphorylation in the hippocampus of old rats exposed to chronic mild stress: Reversal with the neuronal nitric oxide synthase inhibitor 7-nitroindazole

El-faramawy, Yasser A.; Elbanouby, Mohamed H; Сергеев, П. В.; Mortagy, Ahmed K.; Amer, Moatassem S.; Abdel‐tawab, Ahmed M.

doi:10.1016/j.pbb.2008.08.003

Cited by 17 publications

(14 citation statements)

References 62 publications

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“…The effects of EAE and T3 treatments on tau hyperphosphorylation were evaluated in spinal cord extracts using the site‐specific phospho‐tau antibodies PHF1 and CP13 [35] that recognize the phosphorylated Ser 396/404 and Ser 202 respectively (Figure 4). In line with previous evidence [36], Western blot analyses of rat tau proteins revealed two major bands, designated in the Figure 4 as 1 and 2. As detected by PHF1 and CP13 antibodies, clear evidence of the hyperphosphorylation of tau corresponding to band 1 was found in extracts from EAE animals, but not in controls.…”

Section: Resultssupporting

confidence: 88%

Functional and molecular evidence of myelin‐ and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis

Dell'Acqua

Lorenzini²,

D’Intino³

et al. 2012

Neuropathology Appl Neurobio

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Section: Resultssupporting

confidence: 88%

Functional and molecular evidence of myelin‐ and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis

Dell'Acqua

Lorenzini²,

D’Intino³

et al. 2012

Neuropathology Appl Neurobio

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“…2006). A similar patron was observed in a model of chronic stress in old rats, in which a decreased in the enzyme activity of glutamate decarboxylase and increased of hyperphosphorylated Tau was found in the hippocampus (El‐faramawy et al. 2009).…”

Section: Metabolic Dysfunction In Alzheimer’s Diseasesupporting

confidence: 67%

Tau oligomers and aggregation in Alzheimer’s disease

Meraz-Ríos

León

Campos-Peña

et al. 2010

Journal of Neurochemistry

149

102

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J. Neurochem. (2010) 112, 1353–1367. Abstract We are analyzing the physiological function of Tau protein and its abnormal pathological behavior when this protein is self‐assemble into pathological filaments. These aggregates of Tau protein are the main components in many diseases such as Alzheimer’s disease (AD). Recent studies suggest that Tau acquires complex oligomeric conformations which may be toxic. In this review, we emphasized the possible phenomena implicated in the formation of these oligomers. Studies with chemical inductors indicates that the microtubule‐binding domain is the most important region involved in Tau aggregation and showed the requirement of a pre‐arrange Tau in abnormal conformation to promote self‐assembly. Transgenic animal models and AD neuropathology studies showed that post‐translational modifications are also implicated in Tau aggregation and neural cell death during AD development. Therefore, we analyzed some events that could be present during Tau aggregation. Finally, we included a brief discussion of the possible relation between glucose metabolism dysfunction in AD, and data of Tau aggregation by using aggregation inhibitors. In conclusion, the process Tau aggregation deserves further investigations to design possible therapeutic targets to inhibit the toxicity of these aggregates and it is possible that could be extended to other diseases with similar etiology.

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“…In fact, increased extracellular glutamate levels have been demonstrated in the rat hippocampus by several acute and chronic stress paradigms. 86 , 87 This explanation was further supported by pervious findings from our laboratory 88 reporting an increase in hippocampal glutamate level accompanied by a reduction in gamma amino butyric acid due to decrease in glutamic acid decarboxylase activity in CMS paradigm. Contrary to this view, the present study reported a decrease in NO concentrations suggesting a decrease in NO synthase (NOS) activity.…”

Section: Discussionsupporting

confidence: 56%

Paroxetine ameliorates changes in hippocampal energy metabolism in chronic mild stress-exposed rats

Khedr

Nassar

El-Denshary

et al. 2015

NDT

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The molecular mechanisms underlying stress-induced depression have not been fully outlined. Hence, the current study aimed at testing the link between behavioral changes in chronic mild stress (CMS) model and changes in hippocampal energy metabolism and the role of paroxetine (PAROX) in ameliorating these changes. Male Wistar rats were divided into three groups: vehicle control, CMS-exposed rats, and CMS-exposed rats receiving PAROX (10 mg/kg/day intraperitoneally). Sucrose preference, open-field, and forced swimming tests were carried out. Corticosterone (CORT) was measured in serum, while adenosine triphosphate and its metabolites, cytosolic cytochrome-c (Cyt-c), caspase-3 (Casp-3), as well as nitric oxide metabolites (NOx) were measured in hippocampal tissue homogenates. CMS-exposed rats showed a decrease in sucrose preference as well as body weight compared to control, which was reversed by PAROX. The latter further ameliorated the CMS-induced elevation of CORT in serum (91.71±1.77 ng/mL vs 124.5±4.44 ng/mL, P<0.001) as well as the changes in adenos-ine triphosphate/adenosine diphosphate (3.76±0.02 nmol/mg protein vs 1.07±0.01 nmol/mg protein, P<0.001). Furthermore, PAROX reduced the expression of Cyt-c and Casp-3, as well as restoring NOx levels. This study highlights the role of PAROX in reversing depressive behavior associated with stress-induced apoptosis and changes in hippocampal energy metabolism in the CMS model of depression.

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Changes in glutamate decarboxylase enzyme activity and tau-protein phosphorylation in the hippocampus of old rats exposed to chronic mild stress: Reversal with the neuronal nitric oxide synthase inhibitor 7-nitroindazole

Cited by 17 publications

References 62 publications

Functional and molecular evidence of myelin‐ and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis

Functional and molecular evidence of myelin‐ and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis

Tau oligomers and aggregation in Alzheimer’s disease

Paroxetine ameliorates changes in hippocampal energy metabolism in chronic mild stress-exposed rats

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