Changes in glycemic control and skeletal muscle mass indices after dapagliflozin treatment in individuals with type 1 diabetes mellitus

Abstract

Aims/IntroductionDapagliflozin is used for individuals with type 1 diabetes, although the effect of this medication on skeletal muscle mass is not well established. In addition, there are few studies examining the effects of good glycemic control on skeletal muscle mass in type 1 diabetes patients. We investigated changes in glycemic control and skeletal muscle mass with dapagliflozin in individuals with type 1 diabetes, and the association between these changes.Materials and MethodsThis was a post‐hoc analysis of a multicenter, open‐label, non‐randomized, prospective, interventional study in individuals with type 1 diabetes. The participants received dapagliflozin at 5 mg/day for 4 weeks, and were reviewed before and after treatment. Weight‐ and height‐corrected appendicular skeletal muscle mass (ASM) were calculated as indices of skeletal muscle mass using bioelectrical impedance analysis.ResultsA total of 36 individuals were included in the analysis. After the 4 weeks of dapagliflozin treatment, ASM/height2 decreased in the body mass index <23 group (P = 0.004). ASM / weight decreased in all men aged >60 years. The change in ASM / weight (%) was negatively correlated with the change in glycated hemoglobin (%;P = 0.023). The change in ASM / height2 (kg/m2) was also positively correlated with the change in time within the glucose range of 70–180 mg/dL (P = 0.036).ConclusionDapagliflozin treatment of individuals with type 1 diabetes, particularly non‐obese individuals and older men, might result in loss of skeletal muscle mass. However, good glycemic control during treatment might prevent the onset and progression of sarcopenia.

d-Pinitol Improves Diabetic Sarcopenia by Regulation of the Gut Microbiome, Metabolome, and Proteome in STZ-Induced SAMP8 Mice

“…The acceleration of population aging had led to an increased prevalence of DS, characterized by elevated rates of falls, functional disability, and fractures. More research spanning from basic science to clinical studies, has revealed the complexity of DS, however, no specific treatments have been established. − Therefore, it is crucial to identify new targets for sarcopenia, muscle mass, and function loss caused by sustained hyperglycemia. In our present study, we comprehensively investigated the interactions of gut–muscle axis by evaluating multiomics, including gut microbiome, gastrocnemius metabolome, and proteome.…”