Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice

McMahan, Rachel H.; Hulsebus, Holly J.; Najarro, Kevin M.; Giesy, Lauren E.; Frank, Daniel N.; Kovacs, Elizabeth J.

doi:10.1016/j.alcohol.2022.08.011

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…It should also be acknowledged that animals do not perfectly reflect every aspect of the clinical scenario 51 . However, previous studies have shown an impressive array of parallels between human and murine ageing‐ and alcohol‐associated deficiencies including increased susceptibility to infections, impaired wound healing, and heightened liver inflammation 45,52–54 …”

Section: Discussionmentioning

confidence: 99%

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Multi‐omics analysis of alcohol effects on the liver in young and aged mice

Zillich,

Wagner,

McMahan

et al. 2023

Addiction Biology

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Excessive alcohol consumption has detrimental effects on the entire organism, especially on the liver. The toxicity is partly dependent on age, as older individuals metabolize alcohol more slowly leading to increased cellular injury. This study aimed to investigate the effects of moderate binge drinking on the liver of young and aged mice in a genome‐wide multi‐omics approach. We determined DNA methylation (DNAm) using the Illumina MouseMethylation array and gene expression by RNA sequencing in 18 female Balb/c mice in a 2 × 2 design. The animals underwent three moderate binge drinking cycles (ethanol vs. vehicle) and liver tissue was harvested at 4 or 19 months of age. We tested differential gene expression (DE) and DNAm associated with ethanol intake in linear models separately in young and aged mice, performed enrichment analyses for pathways and GWAS signatures of problematic alcohol use, and analysed the overlap of DNAm and gene expression. We observed DE in young and aged animals and substantial overlap in genes such as Bhlhe40, Klf10, and Frmd8. DE genes in aged animals were enriched for biological processes related to alcohol metabolism, inflammation, liver fibrosis, and GWAS signatures of problematic alcohol use. We identified overlapping signatures from DNAm and gene expression, for example, Frmd8 in aged and St6galnac4 in young mice. This study offers converging evidence of novel age‐related targets in a moderate alcohol consumption model highlighting dysregulations in genes related to alcohol metabolism, inflammation, and liver fibrosis. Future studies are needed to confirm these results and elucidate the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

“…51 However, previous studies have shown an impressive array of parallels between human and murine ageing-and alcohol-associated deficiencies including increased susceptibility to infections, impaired wound healing, and heightened liver inflammation. 45,[52][53][54]…”

Section: Analysis Of Dna Methylation and Gene Expression Implicated Thementioning

confidence: 99%

Multi‐omics analysis of alcohol effects on the liver in young and aged mice

Zillich,

Wagner,

McMahan

et al. 2023

Addiction Biology

Self Cite

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“…Moreover, changes in the composition of the gut microbiome can impact tetracycline distribution by altering the permeability of the intestinal barrier [ 108 , 109 , 110 ]. The intestinal barrier acts as a protective layer that prevents the passage of harmful substances into the bloodstream.…”

Section: How Can the Gut Microbiome Alter Tetracycline Treatment?mentioning

confidence: 99%

Bidirectional Interaction between Tetracyclines and Gut Microbiome

Jaroszewski,

Mamun,

Czaja

2023

Antibiotics

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The escalating misuse of antibiotics, particularly broad-spectrum antibiotics, has emerged as a pivotal driver of drug resistance. Among these agents, tetracyclines are widely prescribed for bacterial infections, but their indiscriminate use can profoundly alter the gut microbiome, potentially compromising both their effectiveness and safety. This review delves into the intricate and dynamic interplay between tetracyclines and the gut microbiome, shedding light on their reciprocal influence. By exploring the effects of tetracyclines on the gut microbiome and the impact of gut microbiota on tetracycline therapy, we seek to gain deeper insights into this complex relationship, ultimately guiding strategies for preserving antibiotic efficacy and mitigating resistance development.

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On the critical need to investigate the effect of alcohol in the older population

Matthews

Koob

2023

Alcohol

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Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice

Cited by 6 publications

References 54 publications

Multi‐omics analysis of alcohol effects on the liver in young and aged mice

Multi‐omics analysis of alcohol effects on the liver in young and aged mice

Bidirectional Interaction between Tetracyclines and Gut Microbiome

On the critical need to investigate the effect of alcohol in the older population

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