Changes in Hippocampal Volume in Patients With Post-Traumatic Stress Disorder After Sertraline Treatment

Bossini, Letizia; Tavanti, M.; Lombardelli, A.; Calossi, Sara; Polizzotto, Nicola Riccardo; Galli, Rosita; Vatti, G.; Pieraccini, Fulvio; Castrogiovanni, Paolo

doi:10.1097/01.jcp.0000264979.09862.a8

Cited by 43 publications

(22 citation statements)

References 15 publications

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“…Spectroscopy studies of hippocampus have reported decreased NAA in the hippocampus, often interpreted as consistent with decreased neuronal integrity (Brown et al, 2003;Freeman et al, 1998;Ham et al, 2007a;Mohanakrishnan Menon et al, 2003;Schuff et al, 2001;Villarreal et al, 2002b). The results of two studies suggest that hippocampal volumes may increase following treatment with serotonin reuptake inhibitors (Bossini et al, 2007;Vermetten et al, 2003).…”

Section: Posttraumatic Stress Disordermentioning

confidence: 96%

The Neurocircuitry of Fear, Stress, and Anxiety Disorders

Shin

Liberzon

2009

Neuropsychopharmacol

1,748

927

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Anxiety disorders are a significant problem in the community, and recent neuroimaging research has focused on determining the brain circuits that underlie them. Research on the neurocircuitry of anxiety disorders has its roots in the study of fear circuits in animal models and the study of brain responses to emotional stimuli in healthy humans. We review this research, as well as neuroimaging studies of anxiety disorders. In general, these studies have reported relatively heightened amygdala activation in response to disorder-relevant stimuli in post-traumatic stress disorder, social phobia, and specific phobia. Activation in the insular cortex appears to be heightened in many of the anxiety disorders. Unlike other anxiety disorders, post-traumatic stress disorder is associated with diminished responsivity in the rostral anterior cingulate cortex and adjacent ventral medial prefrontal cortex. Additional research will be needed to (1) clarify the exact role of each component of the fear circuitry in the anxiety disorders, (2) determine whether functional abnormalities identified in the anxiety disorders represent acquired signs of the disorders or vulnerability factors that increase the risk of developing them, (3) link the findings of functional neuroimaging studies with those of neurochemistry studies, and (4) use functional neuroimaging to predict treatment response and assess treatment-related changes in brain function.

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Section: Posttraumatic Stress Disordermentioning

confidence: 96%

The Neurocircuitry of Fear, Stress, and Anxiety Disorders

Shin

Liberzon

2009

Neuropsychopharmacol

1,748

927

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“…Two studies examined effects of SSRIs on hippocampal volume, a structure that is part of the limbic circuitry and closely connected to the amygdala. Both studies found that PTSD patients showed increased volume posttreatment, thereby eliminating pretreatment group differences in hippocampal size 99,100. On the other hand, psychotherapy does not appear to affect the volume of the hippocampus 101.…”

Section: Reexperiencing (Intrusive) Symptomsmentioning

confidence: 99%

Tailoring therapeutic strategies for treating posttraumatic stress disorder symptom clusters

Norrholm

Jovanović²

2010

NDT

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According to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, posttraumatic stress disorder (PTSD) is characterized by three major symptom clusters following an event that elicited fear, helplessness, or horror. This review will examine each symptom cluster of PTSD separately, giving case study examples of patients who exhibit a preponderance of a given symptom domain. We use a translational approach in describing the underlying neurobiology that is relevant to particular symptoms and treatment options, thus showing how clinical practice can benefit from current research. By focusing on symptom clusters, we provide a more specific view of individual patient’s clinical presentations, in order to better address treatment needs. Finally, the review will also address potential genetic approaches to treatment as another form of individualized treatment.

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“…Indeed, previous studies showed that antidepressants increased neurogenesis in adult hippocampal neurons (Anacker et al, 2011;Boldrini et al, 2009). Although no data are available for elderly depression, antidepressant treatment is known to increase hippocampal volume in posttraumatic stress disorder (Bossini et al, 2007). In addition, there were also evidences suggesting increase in cortical thickness of the healthy elderly by cognitive training (Engvig et al, 2010).…”

Section: Limitations and Conclusionmentioning

confidence: 99%

Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression

Lim

Jung

Ahn

et al. 2011

Neuropsychopharmacol

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Previous studies have shown an association between late-onset depression (LOD) and cognitive impairment in older adults. However, the neural correlates of this relationship are not yet clear. The aim of this study was to investigate the differences in both cortical thickness and subcortical volumes between drug-naive LOD patients and healthy controls and explore the relationship between LOD and cognitive impairments. A total of 48 elderly, drug-naive patients with LOD and 47 group-matched healthy control subjects underwent 3T MRI scanning, and the cortical thickness was compared between the groups in multiple locations, across the continuous cortical surface. The subcortical volumes were also compared on a structure-by-structure basis. Subjects with LOD exhibited significantly decreased cortical thickness in the rostral anterior cingulate cortex, the medial orbitofrontal cortex, dorsolateral prefrontal cortex, the superior and middle temporal cortex, and the posterior cingulate cortex when compared with healthy subjects (all p<0.05, false discovery rate corrected). Reduced volumes of the right hippocampus was also observed in LOD patients when compared with healthy controls (p<0.001). There were significant correlations between memory functions and cortical thickness of medial temporal, isthmus cingulate, and precuneus (p<0.001). This study was the first study to explore the relationships between the cortical thickness/subcortical volumes and cognitive impairments of drug-naive patients with LOD. These structural changes might explain the neurobiological mechanism of LOD as a risk factor of dementia.

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Changes in Hippocampal Volume in Patients With Post-Traumatic Stress Disorder After Sertraline Treatment

Cited by 43 publications

References 15 publications

The Neurocircuitry of Fear, Stress, and Anxiety Disorders

The Neurocircuitry of Fear, Stress, and Anxiety Disorders

Tailoring therapeutic strategies for treating posttraumatic stress disorder symptom clusters

Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression

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