Changes in HOMA-IR index levels after bariatric surgery: Comparison of Single Anastomosis Duodenal Switch-proximal approach (SADS-p) and One Anastomosis Gastric Bypass-Mini Gastric Bypass (OAGB-MGB)

Özmen, Mehmet Mahir; Güldoğan, Cem Emir; Gündoğdu, Emre

doi:10.1016/j.ijsu.2020.04.008

Cited by 13 publications

(8 citation statements)

References 35 publications

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“… 5,70 As a result of GBy, patients can lose from 66% to 75% of their excess body weight in the first 24 months after surgery 145,146 . After GBy, patients not only successfully lose weight, but also decrease activity of serum transaminases 147 and improve glycemic control 148,149 . There are several modifications of the GBy, but their essence boils down to the fact that by crossing the stomach in the upper part of it, a “small stomach” with a volume of 20 to 30 mL is formed, to which a loop of the small intestine is sutured.…”

Section: Resultsmentioning

confidence: 99%

“…145,146 After GBy, patients not only successfully lose weight, but also decrease activity of serum transaminases 147 and improve glycemic control. 148,149 There are several modifications of the GBy, but their essence boils down to the fact that by crossing the stomach in the upper part of it, a "small stomach" with a volume of 20 to 30 mL is formed, to which a loop of the small intestine is sutured. By reducing the amount of food consumed and the absorption of nutrients, a decrease in body weight is obtained.…”

Section: Mixed Restrictive and Malabsorptive Proceduresmentioning

confidence: 99%

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Bariatric Surgery

et al. 2022

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Today, bariatric surgery is the most effective treatment of obesity. Restrictive surgeries are aimed at reducing the volume of the stomach. Such operations have the least adverse effects in terms of the physiology of digestion. However, they are less effective in losing weight. Mixed operations (gastric bypass surgery, biliopancreatic diversion) decrease the volume of the stomach and the length of the small intestine. Mixed operations tend to provide more pronounced results in a short time. However, by seriously disrupting the digestion and absorption of the food, they may result in severe micronutrient deficiencies. The assimilation of lipophilic substances is severely impaired as the biliopancreatic system is almost disconnected from the digestive tract. Furthermore, the assimilations of not only fats and essential fatty acids but also all fat-soluble vitamins are interrupted. In most cases, these patients need to take high-dose micronutrient supplements for their whole life. Usually, deficiencies of vitamins A, D, E, C, and vitamins of group B, especially B1, B6, B12, niacin, and folate, as well as iron, calcium, phosphate, magnesium, zinc, copper, and selenium, are found after operations. Restrictive operations, although less traumatic for the digestive system, significantly disrupt the digestion and absorption of nutrients, especially those in which the stomach plays a significant role in its digestion. These are proteins, folate, niacin, vitamin B12, iron, and copper. Bariatric surgical procedures are like a double-edged sword. They can be highly effective in the treatment of obesity and related complications; nevertheless, they are surgeries with serious potential for complications.

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Section: Resultsmentioning

confidence: 99%

Section: Mixed Restrictive and Malabsorptive Proceduresmentioning

confidence: 99%

Bariatric Surgery

et al. 2022

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“…Then serum insulin was detected with EZRMI-13K kit (One Touch Ultra, Johnson & Johnson, CA, USA). Finally, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated to assess the degree of insulin resistance, using the following formula: HOMA-IR=fasting serum insulin (mIU/L)×FBG (mmol/L)/22.5 ( 22 ).…”

Section: Methodsmentioning

confidence: 99%

Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats

Ding¹,

Liu²,

Zhang³

et al. 2022

Front. Endocrinol.

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ObjectiveTo investigate the effects of sleeve gastrectomy (SG) on diabetes-related cognitive decline (DCD) in rats with diabetic mellitus (DM).Methods and methodsForty Wistar rats were randomly divided into control (CON) group (n=10), diabetes mellitus (DM) group (n=10), sham operation (SHAM) group (n=10) and SG group (n=10). DM model was established by high-fat diet (HFD) combined with intraperitoneal injection of streptozocin (STZ). Behavioral evaluation was given using Morris water maze test and Y-maze. In addition, PET-CT, TUNEL assay, histological analysis, transmission electron microscopy (TEM), immunohistochemistry (IHC) and Western blot analysis were used to evaluate the alleviating effects and potential mechanisms of SG on DCD in DM rats.ResultsCompared with the sham group, SG induced significant improvement in the metabolic indices such as blood glucose and body weight. Besides, it could attenuate the insulin resistance compared with SHAM group. In addition, SG could improve the cognitive function of DM rats, which were featured by significant decrease in the escape latency (P<0.05), and significant increase in the time in target quadrant and platform crossings (P<0.05) compared with the SHAM group. SG induced significant elevation in the spontaneous alternation compared with SHAM group (P<0.05). Moreover, SG could improve the arrangement and biosynthesis of hippocampus neuron. Moreover, SG triggered the inhibition of apoptosis of hippocampus neurons, and Western blot analysis showed SG induced significant increase in the ratios of Bcl-2/Bax and Caspase3/cleaved Caspase 3. TEM demonstrated SG could significantly improve the microstructure of hippocampus neurons compared with the SHAM group. Western blot and IHC confirmed the significant decrease in the phosphorylation of tau at Ser404 and Ser396 sites in the SG group. Furthermore, SG activated the PI3K signaling pathway by elevating the phosphorylation of PI3K and Akt and GSK3β compared with the SHAM group.ConclusionSG attenuated the DCD in DM rats, which may be related to the activation of PI3K signaling pathway.

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“…O Duodenal Switch é uma técnica que combina a redução do estômago com a alteração do intestino delgado. Já o Single-Anastomosis Duodenal Switch (SADS) é uma variação do Duodenal Switch, que envolve apenas uma anastomose intestinal (Ozmen et al, 2020;Topart & Becouarn, 2017).…”

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“…Em resumo, as novas técnicas de cirurgia bariátrica, como o Mini-gastric bypass, Duodenal Switch e Single-Anastomosis Duodenal Switch (SADS), têm se mostrado eficazes no tratamento da obesidade. Além disso, a utilização da robótica tem contribuído para aprimorar os resultados e a segurança desses procedimentos (Bauerle et al, 2023;Ozmen et al, 2020;Topart & Becouarn, 2017).…”

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O avanço nas técnicas de cirurgia bariátrica no Brasil: Uma revisão integrativa

Vieira,

Cassarotti

2023

RSD

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A cirurgia bariátrica é considerada uma opção para pacientes com obesidade grave que não obtiveram sucesso significativo com métodos de perda de peso não cirúrgicos. Porém, ainda que exista diversas técnicas, pouco se é discutido sobre elas. Neste contexto, o objetivo deste trabalho foi explorar as novas técnicas cirúrgicas personalizadas para pacientes indicados para bariátrica, considerando ainda a robótica como apoio a essas técnicas. Trata-se de uma revisão integrativa dos últimos 10 anos (2013 a 2023) e que utilizou três bases de dados bibliográficas. Foram utilizados, 21 artigos para compor a revisão. Dentre as técnicas existentes de cirurgia bariátrica, destacam-se a mini Gastric by-pass, a Duodenal Switch e a Single-Anastomosis Duodenal Switch (SADS). Pode-se concluir, também, que a robótica tem auxiliado cirurgias bariátricas ao oferecer maior precisão, visualização tridimensional aprimorada e movimentos mais delicados, contribuindo para procedimentos menos invasivos e recuperações mais rápidas.

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Changes in HOMA-IR index levels after bariatric surgery: Comparison of Single Anastomosis Duodenal Switch-proximal approach (SADS-p) and One Anastomosis Gastric Bypass-Mini Gastric Bypass (OAGB-MGB)

Cited by 13 publications

References 35 publications

Bariatric Surgery

Bariatric Surgery

Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats

O avanço nas técnicas de cirurgia bariátrica no Brasil: Uma revisão integrativa

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