Changes in immune function following surgery for esophageal carcinoma

Tashiro, Tsuguhiko; Yamamori, Hideo; Takagi, Kazuya; Hayashi, Naganori; Furukawa, Katsunori; Nitta, Hiroshi; Toyoda, Yasuyoshi; Sano, Wataru; Itabashi, Terumi; Nishiya, Kei; Hirano, Junko; Nakajima, Nobuyuki

doi:10.1016/s0899-9007(99)00151-3

Cited by 45 publications

(34 citation statements)

References 25 publications

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“…The relationship between the extent of the surgical intervention and the level of the immunosuppressive effect was also reported when comparing moderate (gastrectomy) and major (esophagectomy) open gastrointestinal surgery [29], although controversial results were also described [30]. Tashiro [29] documented that the immunosuppressive effect on cellular functions such as ConAand PHA-stimulated lymphocyte proliferation was clearly demonstrated for 7 days after esophagectomy, but not after gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

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Prolonged Suppression of Humoral Immune Response after Organ Transplantation

Gu¹,

Dahmen²,

Li³

et al. 2002

Eur Surg Res

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Rats receiving either kidney or liver grafts were vaccinated with recombinant hepatitis B virus (HBV) vaccine either 1 or 10 weeks post-transplantation to explore the nonspecific immunosuppressive effect of transplantation surgery on antibody development. Response rate and geometric mean titer of the anti-HBs antibody were significantly lower in organ-transplanted animals undergoing early vaccination compared to unoperated control animals. Both parameters were affected when vaccination was performed early after kidney transplantation, but also in case of late vaccination in liver graft recipients. The nonspecific suppressive effect of transplantation surgery on the humoral immune response was related to the time point of vaccination after surgery and the extent of the surgical intervention and lasted longer than previously reported.

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Section: Discussionmentioning

confidence: 99%

“…Tashiro [29] documented that the immunosuppressive effect on cellular functions such as ConAand PHA-stimulated lymphocyte proliferation was clearly demonstrated for 7 days after esophagectomy, but not after gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Suppression of Humoral Immune Response after Organ Transplantation

Gu¹,

Dahmen²,

Li³

et al. 2002

Eur Surg Res

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“…Esophagectomy with extensive lymph node dissection is a lengthy procedure, inflicting a great deal of stress on patients and resulting in considerable blood loss requiring blood transfusion [15][16][17][18]. Moreover, because of heavy surgical stress under anesthesia, which is clearly greater than that associated with resection of colorectal cancer [19][20][21], esophagectomy itself induces immunosuppression [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, because of heavy surgical stress under anesthesia, which is clearly greater than that associated with resection of colorectal cancer [19][20][21], esophagectomy itself induces immunosuppression [17,18]. We recently reported that the use of autologous blood transfusion significantly improves the 3-year survival rate after esophagectomy, as compared to allogeneic transfusion [22].…”

Section: Introductionmentioning

confidence: 99%

Use of autologous instead of allogeneic blood transfusion during esophagectomy prolongs disease‐free survival among patients with recurrent esophageal cancer

Motoyama¹,

Okuyama²,

Kitamura³

et al. 2004

Journal of Surgical Oncology

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“…Immunosuppression begins immediately after surgery and lasts for hours to several days postoperatively (5)(6)(7)(8). Regulatory T cells (Tregs), characterized by the classical marker proteins CD25 and FOXP3 (9), can exert a broad suppressive effect on antitumor immunity by direct or indirect mechanisms, ultimately resulting in immunological tolerance and escape of tumor cells (10,11).…”

mentioning

confidence: 99%

Propranolol Attenuates Surgical Stress–Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy

Zhou

et al. 2016

The Journal of Immunology

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Surgical stress and inflammatory response induce the release of catecholamines and PGs, which may be key factors in facilitating cancer recurrence through immunosuppression. Animal studies have suggested the efficacy of perioperative blockades of catecholamines and PGs in reducing immunosuppression. In this study, to our knowledge, we present the first report of the effects of perioperative propranolol and/or parecoxib on peripheral regulatory T cells (Tregs) in breast cancer patients. Patients were randomly assigned to control, propranolol, parecoxib, and propranolol plus parecoxib groups. We demonstrated that levels of circulating epinephrine, norepinephrine, and PGE2 increased in response to surgery. Meanwhile, peripheral FOXP3 mRNA level and Treg frequencies were elevated on postoperative day 7. Propranolol administration, rather than parecoxib, attenuated such elevation of Tregs, indicating the critical roles for catecholamines in surgery-induced promotion of Tregs. Besides, propranolol plus parecoxib treatment demonstrated no additive or synergistic effects. Furthermore, a study of Treg activity on CD4+ T cell responses to specific tumor Ags was performed in the control and propranolol groups. Propranolol abrogated the increased Treg activity and accompanying suppression of CD4+ T cell responses after surgery. Finally, we conducted ex vivo experiments on the effects of varying concentrations of epinephrine and/or propranolol on Treg proliferation over PBMCs from breast cancer patients, to provide further direct evidence strengthening our clinical observations. Epinephrine markedly promoted Treg proliferation, whereas propranolol prevented such enhancement effect. In conclusion, our study highlights beneficial roles for propranolol in inhibiting Treg responses in vivo and in vitro, and demonstrates that propranolol could alleviate surgical stress–induced elevation of Tregs in breast cancer patients.

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Changes in immune function following surgery for esophageal carcinoma

Cited by 45 publications

References 25 publications

Prolonged Suppression of Humoral Immune Response after Organ Transplantation

Prolonged Suppression of Humoral Immune Response after Organ Transplantation

Use of autologous instead of allogeneic blood transfusion during esophagectomy prolongs disease‐free survival among patients with recurrent esophageal cancer

Propranolol Attenuates Surgical Stress–Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy

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