Changes in immunologic response in tonsillectomized children. I Immunosuppression in recurrent tonsillitis

Sainz, M.; Gutiérrez, Francisco; Moreno, P.; Munoz, C.; Ciges, M

doi:10.1111/j.1365-2273.1992.tb01677.x

Cited by 25 publications

(18 citation statements)

References 8 publications

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“…It is speculated that tonsillectomy negatively affect the immune system in children. On the other hand, many studies indicate that tonsillectomy seems to have no counterproductive effect on the immune system [7,8].…”

Section: Introductionmentioning

confidence: 97%

Evaluation of long-term impacts of tonsillectomy on immune functions of children: A follow-up study

Kaygusuz¹,

Alpay²,

Gödekmerdan³

et al. 2009

International Journal of Pediatric Otorhinolaryngology

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Section: Introductionmentioning

confidence: 97%

Evaluation of long-term impacts of tonsillectomy on immune functions of children: A follow-up study

Kaygusuz¹,

Alpay²,

Gödekmerdan³

et al. 2009

International Journal of Pediatric Otorhinolaryngology

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“…But another study 7 has shown higher serum of IgA, IgG and IgM level in patients before operation than that of the control group. Sainz et al (1992) 8 in Spain and Lal et al (1984) 9 in India also reported increased level of IgG, IgM and IgA in patients with chronic tonsillitis than that of control group. In the present study before tonsillectomy among the patients with tonsillar disease, serum IgG level was slight higher while IgM, IgA levels were slight lower compared to group B.…”

Section: Discussionmentioning

confidence: 95%

Effect of tonsillectomy on humoral immunity

Nasrin

Miah

Datta

et al. 2012

Bangladesh Med Res Counc Bull

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Tonsils are one of the important secondary lymphoid organ in immune system. It remains controversial whether tonsillectomy results in decreased serum immunoglobulin level. The purpose of this study was to observe the effect of tonsillectomy on humoral immunity parameters among the patients with tonsillar disease. Total group A 70 patients up to the age of 18 years, who were enrolled for tonsillectomy and 30 age matched children group B were included for comparative study. Serum IgG, IgM and IgA levels were measured in all 70 patients before tonsillectomy and in 56 patients who came for 1 st follow-up after one month and 30 patients who came for 2nd follow up after three months of tonsillectomy. Serum IgG, IgM and IgA levels were also measured in group B children. Serum IgG, IgM and IgA levels in patients of group A did not show any significant difference in comparison to group B. One month after tonsillectomy the level of IgG was slightly decreased and IgM and IgA were increased compared to preoperative value but not statistically significant. All IgG, IgM and IgA were also not significantly altered in comparison to group B. Three months after tonsillectomy serum IgG, IgM and IgA level were found decreased in comparison to pre operative value and group B, among which difference of only IgG was significant. After tonsillectomy humoral parameters were found reduced but overall impact on humoral immune status was not significantly altered.

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“…After studying 53 children 3-4 yrs after tonsillectomy, LENANDER-LUMIKARI et al [22] suggested that the surgery did not weaken the humoral immune status of human saliva. Other researchers even suggested that tonsillectomy may improve the immune response [23]. Further studies are warranted to determine immunological mechanisms of predisposition to respiratory illness after T/A in response to ETS exposure.…”

Section: Discussionmentioning

confidence: 99%

Effect of environmental tobacco smoke on cough in children with a history of tonsillectomy or adenoidectomy

Chen

Rennie²,

La³

et al. 1998

Eur Respir J

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We examined the possible impact of tonsillectomy or adenoidectomy (T/A) on the relationship between environmental tobacco smoke (ETS) exposure and respiratory outcomes. This study was conducted in Humboldt, Saskatchewan, in 1993. The target population included all residents aged 6-17 yrs. Of the 1,019 eligible subjects, 892 participated (88%). Estimates of ETS exposure were based on the reported smoking habits of the children's household members. We defined current cough as a positive response to the question: "Does this child usually have a cough?". Information also included morning cough, night cough and a history of T/A. For children with no history of T/A, the prevalence of current cough was 8.9%, 12.2% and 14.5% for those living in families with 0, 1, and 2+ smokers respectively. The corresponding prevalence was 7.0%, 30.2% and 36.8% for children with history of T/A. Similar effects of ETS exposure were observed on morning cough and night cough. The results did not change significantly when we used various ETS measures and controlled for confounding factors. Compared to children living in nonsmoking families and without history of T/A, the adjusted odds ratio for children with a history of T/A was 7.19 (p<0.001) if they were living in families smoking >20 cigarettes x day(-1) at home. The corresponding odds ratio was only 1.64 (p=0.11) for children without a history of T/A. We concluded that children living in smoking family were more likely to cough than those living in nonsmoking families and tonsillectomy or adenoidectomy increased the apparent influence of environmental tobacco exposure on cough.

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Changes in immunologic response in tonsillectomized children. I Immunosuppression in recurrent tonsillitis

Cited by 25 publications

References 8 publications

Evaluation of long-term impacts of tonsillectomy on immune functions of children: A follow-up study

Evaluation of long-term impacts of tonsillectomy on immune functions of children: A follow-up study

Effect of tonsillectomy on humoral immunity

Effect of environmental tobacco smoke on cough in children with a history of tonsillectomy or adenoidectomy

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