Changes in Incidence and Antifungal Drug Resistance in Candidemia: Results From Population-Based Laboratory Surveillance in Atlanta and Baltimore, 2008-2011

Cleveland, Angela A.; Farley, Monica M.; Harrison, Lee H.; Stein, Betsy; Hollick, Rosemary; Lockhart, Shawn R.; Magill, Shelley S.; Derado, Gordana; Park, Benjamin J.; Chiller, Tom

doi:10.1093/cid/cis697

Cited by 343 publications

(337 citation statements)

References 38 publications

Supporting

Mentioning

293

Contrasting

Unclassified

Order By: Relevance

“…The overall incidence of candidemia was found to be comparable to that of other studies around the world [8,[12][13][14][15][16]. However, the reported incidence rate is higher in hospitals in Latin America and Italy (1.2 to 1.7 episode/1000 admission) and lower in hospitals in Northern Europe (0.01 to 0.08 episode/1000 admission) [17][18][19].…”

Section: Discussionsupporting

confidence: 79%

Characteristics and clinical outcomes of patients with Candida bloodstream infections in a tertiary care hospital in Jordan

Ababneh

Abu-Bdair

Mhaidat

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Candida species are important causes of bloodstream infections, accounting for significant morbidity and mortality in hospitalized patients. Methodology: A retrospective observational study was conducted in an academic tertiary hospital of Jordan. The medical records of patients hospitalized over a ten-year period. were reviewed and patients with candidemia were identified. Data analysis included the infecting Candida species, resistance to antifungals, and risk factors associated with mortality. Results: A total of 158 cases of candidemia were identified, with an overall incidence rate of 0.48 episodes/1,000 admissions. The proportion of candidemia caused by Candida albicans (44.3%) was higher than that of candidemia caused by non-albicans Candida species (42.4%). Exposure to antibiotic therapy before hospitalization was the only independent factor associated with non-albicans Candida infection (OR 2.454; p = 0.033). The overall crude 30-day mortality was 38.7%. Central venous catheterization (OR 0.255; p = 0.026), mechanical ventilation (OR 0.162; p = 0.003), severe sepsis and septic shock (OR = 0.073; p = 0.008), admission to intensive care unit (OR 0.78; p = 0.001), C. albicans (OR 0.235; p = 0.018), length of stay (OR 1.057; p = 0.001), number of comorbidities (OR 0.580; p = 0.008) were independent risk factors for 30-day mortality. Conclusion: This study identified several risk factors associated with blood stream infections caused by Candida over 10-years period. Continuous surveillance programs to monitor such types of infection are of great value to antimicrobial stewardship programs.

show abstract

Section: Discussionsupporting

confidence: 79%

Characteristics and clinical outcomes of patients with Candida bloodstream infections in a tertiary care hospital in Jordan

Ababneh

Abu-Bdair

Mhaidat

et al. 2017

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…However, Denmark seems to be an outlier, with an annual average incidence of 8.6/100,000 from 2004 to 2009 (13). At the two extremes among western societies, Australia reports a comparatively low rate of 1.8 cases per 100,000 population (31), whereas a recent population-based surveillance study from the United States conducted from 2008 to 2011 showed incidence rates of 13.3 cases/100,000/year in Atlanta and even as high as 26.2 cases/100,000/year in Baltimore (4). Importantly, all the aforementioned studies documented an overall increase in incidence over the course of study.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, several populationbased surveys in the United States, Canada, Europe, and Australia have reported an increasing incidence. In the United States, the incidence of candidemia has ranged from 6.0 to 13.3/100,000 population per year (4)(5)(6), whereas, at the same time, the incidence rates in most European countries have been lower, ranging from 1.9 to 4.8/100,000/year (7)(8)(9)(10)(11)(12). Exceptionally high incidence of candidemia has recently been reported both in Baltimore, 26.2/ 100,000/year (4), and Denmark, 8.6/100,000/year (13).…”

mentioning

confidence: 99%

Nationwide Study of Candidemia, Antifungal Use, and Antifungal Drug Resistance in Iceland, 2000 to 2011

2013

View full text Add to dashboard Cite

Candidemia is often a life-threatening infection, with highly variable incidence among countries. We conducted a nationwide study of candidemia in Iceland from 2000 to 2011, in order to determine recent trends in incidence rates, fungal species distribution, antifungal susceptibility patterns, and concurrent antifungal consumption. A total of 208 infection episodes in 199 patients were identified. The average incidence during the 12 years was 5.7 cases/100,000 population/year, which was significantly higher than that from 1990 to 1999 (4.3/100,000/year; P ‫؍‬ 0.02). A significant reduction in the use of blood cultures was noted in the last 3 years of the study, coinciding with the economic crisis in the country (P < 0.001). Age-specific incidence rates were highest among patients at the extremes of age, 20.7/100,000 for <1 year of age and 18.1/100,000 for >60 years, and varied by gender. Age-specific incidence among males >80 years old was 28.6/100,000/year, and it was 8.3/100,000/year for females in this age group (P ‫؍‬ 0.028). The 30-day survival rate among adult patients remained unchanged compared to that from 1990 to 1999 (70.4% versus 69.5%, P ‫؍‬ 0.97). Candida albicans was the predominant species (56%), followed by C. glabrata (16%) and C. tropicalis (13%). The species distribution remained stable compared to that from previous decades. Fluconazole use increased 2.4-fold from 2000 to 2011, with no increase in resistance. In summary, the incidence of candidemia in Iceland has continued to increase but may have reached a steady state, and no increase in antifungal drug resistance has been noted. Decreased use of blood cultures toward the end of the study may have influenced detection rates.

show abstract

“…C. albicans was the dominant cause (62.5%) of CBSI [15,16]. CBSI caused by C. lipolytica and C. lusitaniae were rarely reported and accounted for only 7% of all detected CBSI [17,18] [2,19,20]. These variations in the geographical distribution of CBSI incidence is most probably due to demographic differences or dissimilar patient management.…”

Section: Discussionmentioning

confidence: 99%

Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

Stojanović

Stojanović-Radić

et al. 2016

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Candida spp. frequently cause hospital-acquired bloodstream infections (BSI) with a high mortality rate (up to 70%). We analyzed the frequency, infection characteristics, potential predisposing factors, susceptibility to antifungal drugs, biofilm production and other virulence characteristics of Candida spp. isolates obtained from a tertiary care hospital in Niš, Serbia, during a one year period. Methods: Medical histories, characteristics of isolated strains and drug susceptibility, as well as the effect on the function of isolated macrophages and other virulence features were evaluated. The obtained results were subjected to student's t-test and multivariate statistical analyzes. Results: Herein we report an annual incidence of 3.65 cases of C. albicans, C. lusitaniae and C. lipolytica infections per 10 5 population. Out of eight isolated strains, two (25%) were shown to be strong biofilm producers, one (12.5%) caused hemolysis on blood agar and in two (25%) cases macrophages were able to completely eliminate the yeast colonies. Chronic kidney disease, diabetes, malignant and other diseases were present in 37.5, 62.5, 50 and 75%, respectively, in the study group. All patients with Candida BSI received antifungal therapy (amphotericin B), however, hospital mortality was observed in 25% of patients. Conclusions: Evaluation of local Candida epidemiology, antifungal susceptibility and virulence factors, as well as personalized patient risk factors are important for the surveillance of Candida BSI, especially in intensive care unit patients and may contribute to the improved options and outcome for patients with Candida BSI.

show abstract

Changes in Incidence and Antifungal Drug Resistance in Candidemia: Results From Population-Based Laboratory Surveillance in Atlanta and Baltimore, 2008-2011

Cited by 343 publications

References 38 publications

Characteristics and clinical outcomes of patients with Candida bloodstream infections in a tertiary care hospital in Jordan

Characteristics and clinical outcomes of patients with Candida bloodstream infections in a tertiary care hospital in Jordan

Nationwide Study of Candidemia, Antifungal Use, and Antifungal Drug Resistance in Iceland, 2000 to 2011

Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

Contact Info

Product

Resources

About