Changes in Inhibin Secretion during Development of the Female Duck Embryo

Yang, Pei Xin; Arai, Koji Y.; Wan, Jin; Watanabe, Gen; Groome, Nigel P.; Taya, Kazuyoshi

doi:10.2108/zsj.18.1107

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Although, it is now beyond question that the gonad is likey to be a major source of inhibin in males and females, circulating ir-inhibin was measurable even after the gonadectomy [9]. Previous reports demonstrated that the adrenal gland is probably a source of ir-inhibin in mammals [4,10] and avian species [27,37], though amount of secretion of bioactive inhibin are much less in adrenal glands than gonads. In addition, placenta secrete a large amount of immunoreactive and bioactive inhibin during pregnancy in primates [1,18,25].…”

Section: Discussionmentioning

confidence: 99%

Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

et al. 2001

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ABSTRACT. The effects of unilateral and bilateral ovariectomy and passive immunization against inhibin on follicle-stimulating hormone (FSH) secretions and follicular development in the guinea pig were investigated. Bilateral ovariectomy decreased plasma immunoreactive (ir-) inhibin rapidly and increased plasma FSH significantly. Unilateral ovariectomy decreased plasma ir-inhibin and increased plasma FSH temporarily, and doubled the number of ova released from the remaining ovary at the subsequent ovulation in guinea pigs. Injection of 1.0 ml inhibin antiserum significantly increased concentrations of plasma FSH at 6 hr onwards and the number of small follicles (100-200 µm in diameter) at 48 hr after the injection in guinea pigs bearing progesterone-containing implants. In vitro bioassay showed that inhibin antiserum could neutralize the suppression of ovarian homogenate on FSH secretion from cultured rat anterior pituitary cells. These results confirm the evidence that the ovary is the main source of inhibin secretion and both in vitro bioassay and passive immunization against inhibin show that the inhibin is a major regulator in the follicular development through FSH secretion in guinea pigs.

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Section: Discussionmentioning

confidence: 99%

Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

et al. 2001

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“…Concentrations of ir-inhibin in plasma were measured in triplicate using rabbit antiserum against bovine inhibin (TNDH-1) and 125 I-labeled 32-kDa bovine inhibin, as described previously [14], and validated for use in ducks [15]. Results were expressed in terms of 32-kDa bovine inhibin.…”

Section: Radioimmunoassay (Ria) Of Ir-inhibin Fsh Lh Estradiol-17βmentioning

confidence: 99%

Plasma Concentrations of Immunoreactive (ir)-Inhibin, Gonadotropins and Steroid Hormones during the Ovulatory Cycle of the Duck

Yang

Medan

Arai

et al. 2005

Journal of Reproduction and Development

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Abstract. The present study was undertaken to determine changes in circulating levels of immunoreactive (ir)-inhibin, FSH, LH, estradiol-17β, progesterone, and testosterone during the ovulatory cycle of Shao ducks. Serial blood samples were taken from two groups of laying ducks for measurement of ir-inhibin, gonadotropins, and steroid hormones at 2 h intervals for 24 h. Plasma concentrations of ir-inhibin did not change significantly during the ovulatory cycle. The highest level of plasma ir-inhibin was observed 6 h prior to ovulation, which coincided with a decreased level of plasma FSH. One FSH surge was found 12 h after ovulation. Estradiol-17β, progesterone, and testosterone were also determined during the ovulatory cycle. Two peak values were detected for estradiol-17β 8 h before ovulation and 4 h after ovulation, while progesterone started to increase 4 h before ovulation and reached a peak at ovulation. The highest level of plasma testosterone was detected around the time of ovulation. These results suggest that inhibin may be involved in the control of FSH secretion during the ovulatory cycle. In addition, both LH and progesterone are of importance in the ovulation process of Shao ducks.

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“…Immunoreactive inhibin has been detected in plasma and gonadal homogenates of chicken (Rombauts et al . 1992) and duck (Yang et al . 2001) embryos.…”

Section: Introductionmentioning

confidence: 99%

Ontogeny of testicular inhibin and activin in ducks: An immunocytochemical analysis

Yang

Medan

Arai

et al. 2005

Animal Science Journal

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The ontogeny of testicular inhibin/activin in ducks was investigated. Testicular localization of three inhibin/activin subunits (α, β A and β B ) was determined in embryonic and newly hatched ducks from 12 days of incubation to 1 day of age, in immature ducks and in adult ducks. In the duck embryonic testis, positive α-subunit immunostaining was first detected in the Leydig cells and Sertoli cells on day 15 of incubation, whereas β A -subunit and β B -subunit immunostaining were found in Sertoli cells and primary germ cells on day 18 of incubation. In 1 month old ducks, intense staining of α-subunit was present in the seminiferous epithelium consistent with localization in Sertoli cells and primary germ cells, and the immunostaining of the β A -and β B -subunit was also present in Sertoli cells and primary germ cells. Specific immunostaining with inhibin/activin α-, β A -and β B -subunits antisera occurred in Sertoli cells in the adult duck testes. In conclusion, it was shown that, in the duck testis, the majority of α-, β A -and β B -subunits are colocalized in Sertoli cells with a certain degree of staining in germ cells and the α-subunit is present in Leydig cells of embryonic testes before day 18 of incubation. These results indicate that Sertoli cells and possibly germ cells in the embryonic testes of late stage of incubation and newly hatched ducks, immature ducks and mature ducks may produce bioactive inhibin dimers, inhibin A and inhibin B, as a possible regulator of follicle-stimulating hormone secretion. Free inhibin/activin subunits and their dimers may also play an autocrine/paracrine role in the development of the testis and spermatogenesis. Furthermore, early onset of the αsubunit in duck testes indicates that it may have an autocrine/paracrine effect on steroid hormones, which is important for sex differentiation.

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Changes in Inhibin Secretion during Development of the Female Duck Embryo

Cited by 4 publications

References 27 publications

Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

Plasma Concentrations of Immunoreactive (ir)-Inhibin, Gonadotropins and Steroid Hormones during the Ovulatory Cycle of the Duck

Ontogeny of testicular inhibin and activin in ducks: An immunocytochemical analysis

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