Changes in intestinal blood flow during the development of chronic large bowel obstruction

Coxon, Jonny; Dickson, Caroline; Taylor, I

doi:10.1002/bjs.1800711020

Cited by 5 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16]. The methods proposed for the measurement of this tissue blood flow are radionucleidelabeled microspheres [1][2][3]10], radionucleide iodoantipyrine [7] or aminopyrine, or l33Xe washout [1][2][3]14]. Unfortunately, all these techniques are complicated, expensive and cannot be easily repeated.…”

Section: Introductionmentioning

confidence: 99%

A New Laser Doppler Interface for the Continuous Measurement of the Rat Gastric Mucosal Blood Flow

Durlik¹,

Bénichoux²,

Lopez-Gollonet³

et al. 1986

Eur Surg Res

View full text Add to dashboard Cite

The laser Doppler system (LD) has been proposed for a tissue blood flowmetry. However, its accuracy is dependent on the pressure and direction of the laser probe. Therefore, we have devised a new interface for the measurement of the gastric mucosal blood flow in rats keeping the probe constant in pressure and direction. This interface is a small cyclinder with one end fixed upon the gastric serosa and the other end fixed externally upon the skin. The laser probe adjusts exactly in direction and pressure inside this button. The LD apparatus processes two shifted beams with a differential amplification and a root mean square. It delivers an index (LDI) from 0 to 10. This interface was tested in 3 groups of rats, comparing themucosal (open stomach) with the serosal gastric LDIand the same serosal LDI with a ^l33Xe washout flow. Finally, the interface was used in control and restrained rats. The gastric serosal LDIwas found to be similar to the mucosal LDI. The correlation between the LDI and the ¹³³Xe washout flow was good, with a coefficient of 0.9. Finally, the LDI of the gastric mucosal blood was significantly different in control and stressed rats. This new interface makes the LD more reliable for the monitoring of gastric mucosal flowmetry. It has the same accuracy as the xenon washout and additionally it is simpler, cheaper and may be repeated or even be used continuously.

show abstract

Section: Introductionmentioning

confidence: 99%

A New Laser Doppler Interface for the Continuous Measurement of the Rat Gastric Mucosal Blood Flow

Durlik¹,

Bénichoux²,

Lopez-Gollonet³

et al. 1986

Eur Surg Res

View full text Add to dashboard Cite

show abstract

Vascular responsiveness in obstructed gut

Neville

Fielding

Cambria

et al. 1991

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

Multiorgan system failure due to hypotension and sepsis is an important cause of death in patients with bowel obstruction. We have investigated the pathophysiology of this entity in an animal model. After 5 days of bowel obstruction, blood flow in the superior mesenteric artery was measured with and without Pitressin and norepinephrine given in separate experiments. In controls, Pitressin in moderate dosages caused a substantial fall in gut blood flow, which was not seen in obstructed animals (blood flow reduction 52 percent vs. 11 percent in sham and obstructed animals respectively, P less than 0.01). Similarly, norepinephrine infusion had less of an effect on gut blood flow in obstructed animals (blood flow reduction 79 percent vs. 58 percent sham vs. obstructed animals (P less than 0.05). Thus, both agents had dose-related effects on gut blood flow, which was maintained at a higher level throughout the drug infusion periods in the bowel of obstructed animals, demonstrating that splanchnic flow is less responsive to vasoactive drug infusion under these experimental conditions. Because splanchnic vasoconstriction is an important feature of normal hemodynamic homeostasis, we suggest that these results may help explain some aspects of the pathophysiology of multiorgan failure caused or worsened by systemic hypotension seen in bowel obstruction.

show abstract

Effect of large-bowel obstruction on colonic blood flow

Papanicolaou¹,

Ahn²,

Nikas³

et al. 1989

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

The effect of subacute large-bowel obstruction on the mesenteric circulation was studied in a chronic dog model. Colonic obstruction was produced 40 cm distal to the ileocolic sphincter. Five days later, gut blood flow was measured with 15 microns microspheres, together with hemodynamic and metabolic values. Two other groups provided comparative data: unoperated animals to measure baseline values and sham-operative controls. With adequate hydration, hemodynamic and metabolic values remained stable in the experimental group. There was a two-fold increase (P less than 0.05) in blood flow in the dilated colon proximal to the obstruction site, whereas blood flow to the other organs remained unchanged. These results have relevance for the hemodynamic management and use of primary anastomosis in patients with large-bowel obstruction. Furthermore, these data might implicate increased local bowel blood flow as a contributory factor to the poorer long-term prognosis found in patients with large-bowel cancer presenting with intestinal obstruction.

show abstract

Changes in intestinal blood flow during the development of chronic large bowel obstruction

Cited by 5 publications

References 18 publications

A New Laser Doppler Interface for the Continuous Measurement of the Rat Gastric Mucosal Blood Flow

A New Laser Doppler Interface for the Continuous Measurement of the Rat Gastric Mucosal Blood Flow

Vascular responsiveness in obstructed gut

Effect of large-bowel obstruction on colonic blood flow

Contact Info

Product

Resources

About