Changes in Intrinsic Properties of Pyramidal Neurons in Adult Rat S1 During Cortical Reorganization

Hickmott, P. W.

doi:10.1152/jn.00924.2004

Cited by 8 publications

(2 citation statements)

References 67 publications

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“…5 C and D). Reduced intrinsic excitability has also been observed previously after whisker deprivation (37) and peripheral denervation (38). The reduced firing rate was associated with increased spike width (ANOVA P = 0.012) but no change in spike threshold (Fig.…”

Section: Pw-evoked Excitation and Inhibitionsupporting

confidence: 83%

Rapid homeostasis by disinhibition during whisker map plasticity

Gainey

Goldbeck

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance Neurons exhibit distinct homeostatic and Hebbian forms of plasticity that stabilize firing rate and adaptively alter synaptic input patterns, respectively. How these mechanisms are recruited in response to sensory experience in vivo is unclear. We studied plasticity in rodent somatosensory cortex, where the neural map of the whiskers adaptively changes to reflect sensory statistics but only after a prominent initial delay. By recording synaptic excitation and inhibition in vivo, we found that the delay reflects not a lack of plasticity but a rapid homeostasis, in which inhibition is powerfully reduced to offset the initial Hebbian reduction of whisker-evoked excitation. Thus, rapid homeostasis by disinhibition stabilizes the whisker map and precedes classical whisker map plasticity.

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Section: Pw-evoked Excitation and Inhibitionsupporting

confidence: 83%

Rapid homeostasis by disinhibition during whisker map plasticity

Gainey

Goldbeck

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Indeed Shoykhet and Simons (2008) recently reported that the tuning properties of barrel cortex develop within a similar time frame (P14 -P28), consistent with the maturation of excitatory and inhibitory synaptic connections (Blue and Parnavelas 1983;White et al 1997). On the other hand, the membrane and response properties of individual cortical neurons are fully mature by P14 (Maravall 2004) and change very little in adult (Hickmott 2005) or senescent rats (Burke and Barnes 2006).…”

Section: Barrel Neurons In Vitro Versus In Vivomentioning

confidence: 99%

Response Sensitivity of Barrel Neuron Subpopulations to Simulated Thalamic Input

Pesavento

Rittenhouse²,

Pinto

2010

Journal of Neurophysiology

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Our goal is to examine the relationship between neuron- and network-level processing in the context of a well-studied cortical function, the processing of thalamic input by whisker-barrel circuits in rodent neocortex. Here we focus on neuron-level processing and investigate the responses of excitatory and inhibitory barrel neurons to simulated thalamic inputs applied using the dynamic clamp method in brain slices. Simulated inputs are modeled after real thalamic inputs recorded in vivo in response to brief whisker deflections. Our results suggest that inhibitory neurons require more input to reach firing threshold, but then fire earlier, with less variability, and respond to a broader range of inputs than do excitatory neurons. Differences in the responses of barrel neuron subtypes depend on their intrinsic membrane properties. Neurons with a low input resistance require more input to reach threshold but then fire earlier than neurons with a higher input resistance, regardless of the neuron's classification. Our results also suggest that the response properties of excitatory versus inhibitory barrel neurons are consistent with the response sensitivities of the ensemble barrel network. The short response latency of inhibitory neurons may serve to suppress ensemble barrel responses to asynchronous thalamic input. Correspondingly, whereas neurons acting as part of the barrel circuit in vivo are highly selective for temporally correlated thalamic input, excitatory barrel neurons acting alone in vitro are less so. These data suggest that network-level processing of thalamic input in barrel cortex depends on neuron-level processing of the same input by excitatory and inhibitory barrel neurons.

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Activity-dependent changes in the electrophysiological properties of regular spiking neurons in the sensorimotor cortex of the rat in vitro

Canu

Picquet

Bastide

et al. 2010

Behavioural Brain Research

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Changes in Intrinsic Properties of Pyramidal Neurons in Adult Rat S1 During Cortical Reorganization

Abstract: Hickmott, Peter W. Changes in intrinsic properties of pyramidal neurons in adult rat S1 during cortical reorganization.

Cited by 8 publications

References 67 publications

Rapid homeostasis by disinhibition during whisker map plasticity

Rapid homeostasis by disinhibition during whisker map plasticity

Response Sensitivity of Barrel Neuron Subpopulations to Simulated Thalamic Input

Activity-dependent changes in the electrophysiological properties of regular spiking neurons in the sensorimotor cortex of the rat in vitro

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