Changes in lipid peroxidation and antioxidant system of the brain during early postnatal development in rats

Galkina, Olga; Putilina, F. E.; Romanova, Anna; Eshchenko, N. D.

doi:10.1134/s1819712409020032

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…In good agreement with this finding, ketamine-induced increase in MDA content in the cortex of young rodents, associated with elevations in levels of indirect markers of oxidative stress were previously reported ( Cheung and Yew, 2019 ). Interestingly, changes in brain lipid peroxidation have been described during early postnatal development, with a physiological decrease in adult animals ( Galkina et al, 2009 ). Indeed, during the neonatal period, brain has been reported to have low peroxidation potential corresponding to the rapid phase of cell proliferation ( Pushpendran et al, 1994 ).…”

Section: Discussionmentioning

confidence: 99%

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Postnatal Antioxidant and Anti-inflammatory Treatments Prevent Early Ketamine-Induced Cortical Dysfunctions in Adult Mice

et al. 2020

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Early brain insult, interfering with its maturation, may result in psychotic-like disturbances in adult life. Redox dysfunctions and neuroinflammation contribute to long-term psychiatric consequences due to neurodevelopmental abnormalities. Here, we investigated the effects of early pharmacological modulation of the redox and inflammatory states, through celastrol, and indomethacin administration, on reactive oxygen species (ROS) amount, levels of malondialdehyde (MDA) and antioxidant enzymes (superoxide dismutase 1, SOD1, glutathione, GSH, and catalase, CAT), as well as of pro-inflammatory cytokines (tumor necrosis factor-alpha, TNF-α, interleukin-6, IL-6, and interleukin-1 beta, IL-1β), in the prefrontal cortex of adult mice exposed to a neurotoxic insult, i.e. ketamine administration, in postnatal life. Early celastrol or indomethacin prevented ketamine-induced elevations in cortical ROS production. MDA levels in ketamine-treated mice, also administered with celastrol, were comparable with the control ones. Indomethacin also prevented the increase in lipid peroxidation following early ketamine administration. Whereas no significant differences were detected in SOD1, GSH, and CAT levels between ketamine and saline-administered mice, celastrol elevated the cortical amount of these antioxidant enzymes and the same effect was induced by indomethacin per se . Both celastrol and indomethacin prevented ketamine-induced enhancement in TNF-α and IL-1β levels, however, they had no effects on increased IL-6 amount resulting from ketamine exposure in postnatal life. In conclusion, our data suggest that an early increase in cortical ROS scavenging and reduction of lipid peroxidation, via the enhancement of antioxidant defense, together with inhibition of neuroinflammation, may represent a therapeutic opportunity against psychotic-like disturbances resulting, later in life, from the effects of a neurotoxic insult on the developing brain.

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Section: Discussionmentioning

confidence: 99%

“…have been described during early postnatal development, with a physiological decrease in adult animals (Galkina et al, 2009). Indeed, during the neonatal period, brain has been reported to have low peroxidation potential corresponding to the rapid phase of cell proliferation (Pushpendran et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Postnatal Antioxidant and Anti-inflammatory Treatments Prevent Early Ketamine-Induced Cortical Dysfunctions in Adult Mice

et al. 2020

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“…In recent years, domestic and foreign scientists have been actively studying the effects of antioxidants on human health since oxidative stress is the cause of most cardiovascular, neurodegenerative, endocrine and other diseases [10,11]. In the human body, the endogenous synthesis of antioxidants depends on their intake with food [12].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the bioavailability of minerals and antioxidant activity of the grain bread in the in vivo experiment

Alekhina¹,

Пономарева²,

Zharkova³

et al. 2018

Russ Open Med J

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The aim of the study was to determine the bioavailability of minerals and oxidation-antioxidant status in the laboratory animals fed with bread from regular and bioactivated wheat grain. Material and Methods -Studies were conducted for 21 days on white inbred BALB/с mice. The animals were organized in three groups with 30 mice in each one. Group 1 (control group) was given the complete compound feed; Group 2 was fed with regular whole wheat bread; and Group 3 was given the bread from the bioactivated wheat grain. Their blood plasma was tested for total protein, cholesterol, glucose, low and high density lipoproteins, phosphorus, calcium, magnesium, iron, zinc, malondialdehyde (MDA) levels, and the activity of superoxide dismutase (SOD). Calcium was detected histochemically using McGee-Russell's method with Alizarin red S. Results -It was established that the levels of glucose, total protein, cholesterol, and lipids in the blood plasma of animals in all groups were within the physiological norms. There were no significant reliable deviations in the levels of mineral substances in the blood plasma of the animals in the study groups. However, the histochemical response of the bone tissue calcium to the Alizarin red S revealed significant differences in its content in the tissues between the animals of the three groups. At the 21 st day of the experiment, the maximum light absorption of the colored specimen was observed in Group 3 which indicated higher calcium content in the bone tissue of the animals fed with the bread from the bioactivated wheat grain. The oxidation-antioxidant status of the animals in Groups 2 and 3 was higher than that of the control group. On the 21 st day of the experiment, MDA content in the blood plasma of the animals in Group 3 was 0.04±0.017 mmol/L which is 2.0 and 1.5 times less as compared to Groups 1 and 2 respectively. The activity of SOD in the blood plasma on the 21 st day of the experiment was the highest in Group 3 animals. Conclusion -The experiment on the laboratory mice has shown that the use of the bread from the bioactivated wheat grain makes it possible to improve the bioavailability of minerals and increase the antioxidant activity of blood plasma.

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The effects of prenatal hypobaric hypoxia on the level of lipid peroxidation in the neocortex and hippocampus of rats

2015

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Changes in lipid peroxidation and antioxidant system of the brain during early postnatal development in rats

Cited by 5 publications

References 21 publications

Postnatal Antioxidant and Anti-inflammatory Treatments Prevent Early Ketamine-Induced Cortical Dysfunctions in Adult Mice

Postnatal Antioxidant and Anti-inflammatory Treatments Prevent Early Ketamine-Induced Cortical Dysfunctions in Adult Mice

Assessment of the bioavailability of minerals and antioxidant activity of the grain bread in the in vivo experiment

The effects of prenatal hypobaric hypoxia on the level of lipid peroxidation in the neocortex and hippocampus of rats

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