Changes in lonized and total calcium concentrations in serum and urine during open heart surgery

Yamagata, Kenji; Tsuchioka, H; Abe, Toshio; Iyomasa, Y

doi:10.1016/0006-2944(78)90060-1

Cited by 6 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MOf fitt and co-workers ( 18) found a significant increase in PIH levels during bypass which returned to prebypass levels by the end of the bypass period . Roth Yo shioka (38) and Moffi tt ( 18) observed a decrease in ionized calcium levels during bypass, which they att ributed to a respiratory and metabolic alkalosis which persisted in their pat ient s. Mof fi tt explained the increase in PTII levels on the basis of this alkalosis and the decreased ionized calcium. Yoshioka att ributed the decrease in PIH to a circulato ry insufficiency in the distal organs at the beginning of bypass.…”

Section: Discussionmentioning

confidence: 97%

“…Cardiopulmonary bypass has been shown to cause significant metabolic disturbances in a number of electrolytes ( 12, 18. 35, 38) ( 12,18,38), the results have been inconclusive. Yo sllo ka and co-workers (38) measured a decrease in PIH at the beginning of bypass, which returned to prebypass levels by the end of bypass.…”

Section: Discussionmentioning

confidence: 99%

“…Under normal physiological co nditions, ionized calcium has a direct negative feedback on parathyroid hormone l 20, 22) ; consequently, both ionized calcium and parathy roid hormone (PTH) are best studied in co nj unction. Previous studies which have measured ionized calcium and PTH (b y radioimmu noassay) have Pt'> duced co nflicting results tI2 , 18,35,38). Thus, in the second part of th is study , a recently developed cytochemical bioassay for PTH ( 5) was used to measure bloactive PTH during and after open heart surgery, to investigat e whethe r the normal homeostasis of anoth er hormone was affected by the non-ph ysiological influence of non-pulsatile cardiop ulmonary bypass.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Hormonal and Electrolyte Responses during and after Open Heart Surgery

Chambers¹,

Karimzandi²,

Braimbridge³

et al. 1984

Thorac cardiovasc Surg

View full text Add to dashboard Cite

Maintenance of the balance of electrolytes and hormones within their normal range is necessary for normal myocardial metabolism. Open heart surgery involving cardiopulmonary bypass produces metabolic disturbances which affect normal metabolic homeostasis. Several studies have suggested that pulsatile cardiopulmonary bypass causes less severe metabolic disturbance than non-pulsatile bypass and that non-pulsatile bypass causes hypofunction of the anterior pituitary and adrenal glands. The present study, however, with non-pulsatile flow showed that there was no evidence of hypothalamo-pituitary-adrenal axis hypofunction when the hormonal values of corticotrophin (ACTH), cortisol and cortisone were corrected for the hemodilution involved in cardiac surgery. Electrolytes, particularly calcium, play an important role in myocardial contractility. The levels of ionized calcium are normally controlled by parathyroid hormone (PTH) with a negative feedback of calcium controlling the system. However, this study showed that significant increases in bioactive PTH during cardiopulmonary bypass were not related to the calcium concentration, but appeared to be influenced by low blood pH values and by the degree of hypothermia.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation