Changes in lymphocyte subsets in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Abstract

Overall, our study showed that plasma TCDD levels had no effect on white blood cell counts and major subsets. However, a non-significant decrease in most lymphocyte subsets was noted, with the strongest effect for B cells. The latter finding may suggest that dioxin exposure might have an adverse impact on the haematopoietic system and lends some support to B cell lymphoma induction by dioxin.

Serum metabolomic pertubations among workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)

“…Participants were asked to complete a self‐administered questionnaire, which included questions on occupational history, personal medical history, medication used in the weeks prior to the blood collection, anthropometric characteristics, smoking status and alcohol intake. Blood plasma samples were collected according to a standard protocol during home visits between May 2007 and September 2008 [Boers et al, ; Saberi Hosnijeh et al, ].…”

A review of the role of lymphoma markers and occupational and environmental exposures

“…A possible association between TCDD exposure and NHL risk was recently confirmed in a follow-up of this cohort (Boers et al 2010). It was found that most lymphocyte subsets, in particular the B cell compartment, decreased in absolute counts with increasing TCDD exposure levels (Saberi Hosnijeh, Lenters, et al 2012). Moreover, blood levels of most cytokines, chemokines, and growth factors had a negative association with TCDD levels with a formal statistical significance for fractalkine, transforming growth factor alpha (TGF-), and fibroblast growth factor 2 (FGF2) (Saberi Hosnijeh, ).…”

“…The studied participants were among the highest exposed occupational individuals, based on blood TCDD concentrations, and certainly higher than the levels that have been found in environmental settings Saberi Hosnijeh, Lenters, et al 2012). The main findings of the relevant published studies that investigated immunological changes in relation to dioxin exposure are summarized in Table 1. 5.1.1.…”

“…Therefore, the value of these observations is not clear. Nevertheless, the possible effects of TCDD on suppression of the immune system Saberi Hosnijeh, Lenters, et al 2012) cannot be excluded, a process which has been linked to NHL in prospective studies (Grulich et al 2007). …”

“…We assessed a broad range of immunologic parameters directed toward detecting changes in both the humoral and cellular arms of the immune system among Dutch workers occupationally exposed to high levels of TCDD approximately 35 years after last exposure Saberi Hosnijeh, Lenters, et al 2012). The Dutch herbicide cohort consists of workers from two chemical factories in the Netherlands involved in the production and formulation of chlorophenoxy herbicides (Hooiveld et al 1998).…”