2006
DOI: 10.1111/j.1469-0691.2005.01348.x
|View full text |Cite
|
Sign up to set email alerts
|

Changes in macrolide resistance among respiratory pathogens after decreased erythromycin consumption in Taiwan

Abstract: Measures to alleviate the growing problem of macrolide resistance in Taiwan resulted in a decrease in macrolide consumption, from 0.629 defined daily doses/1000 inhabitants per day (DIDs) in 1999 to 0.301 DIDs in 2003 (a reduction of 52%). A linear relationship was observed between the decline in erythromycin consumption and the decline in erythromycin resistance in Streptococcus pyogenes (46% in 1999 vs. 17% in 2003; p < 0.001) and azithromycin resistance in Haemophilus influenzae (31% in 2000 vs. 0% in 2003;… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
20
2
3

Year Published

2008
2008
2011
2011

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 26 publications
(26 citation statements)
references
References 14 publications
1
20
2
3
Order By: Relevance
“…Although we did not test for erythromycin resistance, we found some resistance even to new macrolides. Since restriction of macrolide use in Taiwan, a linear relationship has been noted between the decline in erythromycin use and the decline in erythromycin resistance in S. pyogenes (15). Our study, however, found no decline in macrolide resistance from fi rst half of the study period (27.1%) to the second half (37.0%).…”
Section: Discussioncontrasting
confidence: 68%
See 1 more Smart Citation
“…Although we did not test for erythromycin resistance, we found some resistance even to new macrolides. Since restriction of macrolide use in Taiwan, a linear relationship has been noted between the decline in erythromycin use and the decline in erythromycin resistance in S. pyogenes (15). Our study, however, found no decline in macrolide resistance from fi rst half of the study period (27.1%) to the second half (37.0%).…”
Section: Discussioncontrasting
confidence: 68%
“…For years in Taiwan, macrolide resistance of streptococci has been a major health problem (14,15). A previous study found erythromycin resistance in 23.5% of GGS strains (14).…”
Section: Discussionmentioning
confidence: 99%
“…9 Recently, Hsueh et al reported that decreased erythromycin consumption in Taiwan was responsible for reduced erythromycin resistance rates since 2001 in S. pyogenes isolates only, but not in S. pneumoniae. 10 Based on previous reports from Taiwan, factors influencing decrease in erythromycin resistance rate in S. pyogenes include (1) reduced erythromycin consumption, (2) shift in genotype from erm(B) to mef(A), and (3) decrease in isolates carrying plasmid pA15 that mediate cMLS B phenotype. 10,13,20 The objectives of the present study were (1) to determine the prevalence rate of erythromycin and clindamycin resistance and MIC of the GBS clinical isolates, and (2) to investigate the mechanism(s) responsible for the MLS B resistance.…”
Section: Introductionmentioning
confidence: 99%
“…Daar staat tegenover dat het antibiotisch behandelen van alle exacerbaties een belangrijke stijging van het antibioticagebruik met zich mee zal brengen, waardoor resistentie van respiratoire pathogenen toeneemt. [38][39][40][41][42] Daarom zijn prospectieve vervolgonderzoeken nodig om te exploreren voor welke exacerbaties antibiotica met name zijn geïndiceerd. was de mortaliteit tijdens de follow-up significant lager in de groep die ook antibiotica had gekregen.…”
Section: Cox-survivalanalyseunclassified