Changes in mediators of inflammation and pro-thrombosis after 12 months of dietary modification in adults with metabolic syndrome

Abstract

Objective: This study evaluated the effects of a 12-month dietary modification on indices of inflammation and pro-thrombosis in adults with metabolic syndrome (MS). Materials and methods:This longitudinal study involved 252 adults with MS recruited from the Bodija market, Ibadan and its environs. Participants were placed on 20%, 30% and 50% calories obtained from protein, total fat and carbohydrate respectively and were followed up monthly for 12 months. Anthropometry and blood pressure were measured using standard methods. Fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), fibrinogen, plasminogen activator inhibitor-1 (PAI-1)], interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured using spectrophotometric methods and ELISA as appropriate. Data was analysed using ANCOVA, Student's t-test, Mann-Whitney U and Wilcoxon signed-rank tests. P-values less than 0.05 were considered significant. Results: After 6 months of dietary modification, there was a significant reduction in waist circumference (WC), while the levels of HDL-C, fibrinogen and PAI-1 were significantly increased when compared with the corresponding baseline values. However, WC and fibrinogen reduced significantly, while HDL-C and IL-10 significantly increased after 12 months of dietary modification as compared with the respective baseline values. Conclusion: Long-term regular dietary modification may be beneficial in ameliorating inflammation and pro-thrombosis in metabolic syndrome. Sci. 2017;17(2): 453-462. https://dx.doi.org/10.4314/ahs.v17i2.20

Sex-Specific Energy Intakes and Physical Activity Levels According to the Presence of Metabolic Syndrome in Korean Elderly People: Korean National Health and Nutrition Examination Survey 2016–2018

“…These typical risk factors are associated with high levels of C-reactive protein and homocysteine, which indicate a pro-inflammatory state in the blood vessels [ 18 ]. The pro-inflammatory state causes hyper-viscosity by activating blood coagulation reactions, increasing the level of plasminogen activator inhibitor (PAI)-1 or fibrinogen [ 19 ], and increasing the level of low-density lipoprotein cholesterol (LDL-C). Additionally, the resting heart rate increases due to stress, activating the sympathetic nervous system and decreasing the activation of the parasympathetic nervous system [ 20 , 21 ].…”

Relation of Disturbances in the Erythrocytes Electrical Activity With Dyslipidemia in the Metabolic Syndrome

“…Подобные изменения функционального состояния эритроцитов могут быть обусловлены активацией процессов перекисного окисления липидов и пероксидацией липидов мем- бран с изменением конформационных свойств бел-ков, диффузией и переориентацией в мембране фос-фолипидов, несущих на себе отрицательные заряды [14,15]. В литературе имеются данные о том, что лече-ние метаболических нарушений (ожирения, дислипи-демии) как диетическими, так и фармакологическими методами (полиненасыщенными жирными кисло-тами, статинами в монотерапии и в комбинации с эзе-тимибом) способствует улучшению функционального состояния эритроцитов [16][17][18]. Это является допол-нительным свидетельством патогенетической связи метаболических нарушений и величины ЭЗЭ.…”

Etiology of Cancer Associated Thromboembolism (CAT), and Diet, Lifestyle and Medicine to Reduce Cancer and Venous Thromboembolism

“…Furthermore, consumption of grape suppresses thrombin generation and enhances fibrinolysis [44]. Diets with 20, 30, and 50% of their calories on protein, lipids, and carbohydrates for 12 months result in reduction of abdominal circumference, increased HDL-C, decreased fibrinogen, and significantly increased interleukin-10 in those with metabolic syndrome [45]. These reports suggest that diet and nutrition might directly affect the blood coagulation and fibrinolysis which play an important role in the development of VTE.…”