Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study

Lee, Hyunji; Han, Kyung Do; Park, Hae Eun; Han, Ju Hee; Bang, Chul Hwan; Park, Young Min; Lee, Ji Hyun

doi:10.1038/s41598-021-03174-2

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…Although the exact causal relationship between IR and psoriasis has not been fully established, observational studies have shown that waist circumference has the strongest association with psoriasis, followed by high-density lipoprotein and triglyceride levels. Additionally, patients with persistent metabolic syndrome have a higher risk of developing psoriasis ( 33 ). Our own study supports these findings.…”

Section: Discussionmentioning

confidence: 99%

Positive association between different triglyceride glucose index-related indicators and psoriasis: evidence from NHANES

Huang,

Ma,

Zhong

et al. 2023

Front. Immunol.

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BackgroundPsoriasis is a chronic inflammatory skin disease with effects that extend beyond the skin. Insulin resistance (IR) has been associated with psoriasis, but it remains unclear how indicators related to the triglyceride glucose (TyG) index, which were associate with IR, are associated with the condition.ObjectiveThe purpose of this study was to investigate the association between psoriasis and three TyG-related indicators: triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist to height ratio (TyG-WHtR), and triglyceride glucose-waist circumference (TyG-WC).MethodsData from adults aged 20 to 80 years in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2006 and 2009 to 2014 were utilized. Institutional Review Board approval and documented written consent was obtained from participants by NHANES (Protocol #2005–06). The patients were divided into three groups based on TyG-BMI, TyG-WC, and TyG-WHtR: Q1 (1st quintile), Q2 (2nd-3rd quintiles), and Q3 (4th-5th quintiles). Differences between the groups were further explored. Multivariate logistic regressions were used to investigate the correlation between these three indicators and psoriasis, with results expressed as odds ratios (OR) and 95% confidence intervals (CI). Subgroup analysis and supplementary analysis was further conducted to explore potential influencing factors.ResultsThe study included 9,291 participants, of which 260 had psoriasis. Compared Q2 and Q3 of TyG-BMI, TyG-WC, and TyG-WHtR to Q1, there were significantly associate with psoriasis. Among the three indicators, TyG-WC consistently had the highest OR values in Models 1 and 2 (Model 1: Q3 OR (95% CI) = 2.155 (1.442-3.220); Model 2: Q3 OR (95% CI) = 2.029 (1.341-3.069)). While in Model 3, the TyG-BMI shows more significant relationship with psoriasis (Model 3 of TyG-BMI: Q3 OR (95% CI) = 1.948 (1.300-3.000)). Similar results were observed in the majority of subgroups and in supplementary analysis.ConclusionThis study identified a stable and strong positive association between TyG-related indicators (TyG-BMI, TyG-WC, and TyG-WHtR) and psoriasis. This association persisted even after adjusting for multiple factors. It is suggested that high IR is significantly associated with psoriasis.

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Section: Discussionmentioning

confidence: 99%

Positive association between different triglyceride glucose index-related indicators and psoriasis: evidence from NHANES

Huang,

Ma,

Zhong

et al. 2023

Front. Immunol.

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“…Psoriasis patients are typically dyslipidemic [26]. Recent studies have reported that psoriasis decreases cholesterol efflux capacity as well as HDL composition [6,27,28]. A previous study reported that HDL's antioxidant and anti-inflammatory effects decreased in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models

Liu

Niu

et al. 2022

Lipids Health Dis

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Background Psoriasis is a chronic inflammatory skin disorder related to dyslipidemia, with decreased high-density lipoprotein (HDL). Various cell types express phospholipid transfer protein (PLTP) as well as cholesteryl ester transfer protein (CETP). Their elevated levels among transgenic (Tg) mice led to reduced HDL and a higher risk of atherosclerosis (AS). This study examined whether elevated CETP and PLTP could aggravate psoriasis in a psoriasis vulgaris mouse model. Methods The back skins of CETP-Tg, PLTP-Tg, and C57BL/6 male mice, aged six to 8 weeks, were shaved for imiquimod cream (IMQ) (5%) treatment for five consecutive days. The clinical pathological parameters were rated independently using the modified target lesion psoriasis severity score. The skin sections stained with hematoxylin-eosin were scored by the Baker score. Epidermal thickening and differentiation and inflammatory factor infiltration were determined by immunohistochemistry. Inflammatory cytokine levels were measured using quantitative reverse transcription-polymerase chain reaction (RT–PCR) and enzyme-linked immunosorbent assay (ELISA) kits. This work employed SPSS Statistics Version to conduct statistical analyses. Results In this study, CETP-Tg and PLTP-Tg mice had higher clinical and histological scores than wild-type (WT) mice. Immunohistochemistry of the epidermis and dermis revealed a high proportion of proliferating cell nuclear antigen (PCNA) positivity within psoriatic skin lesions of CETP-Tg and PLTP-Tg mice compared with WT mice. Interferon-α (IFN-α), interleukin-1β (IL-1β), IL-6, IL-17A, IL-17F, IL-22, and IL-23p19 mRNA levels increased within CETP-Tg and PLTP-Tg mice compared with WT counterparts. In comparison with WT mice, plasma tumor necrosis factor-α (TNF-α) levels, rather than IL-6 levels, were increased in CETP-Tg and PLTP-Tg mice. Conclusions Elevated CETP and PLTP aggravate psoriasis in a imiquimod-induced mouse model.

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“…Patient:innen mit einer Psoriasis haben in Abhängigkeit von Erkrankungsschwere und -dauer ein erhöhtes Risiko, ein metabolisches Syndrom als Komorbidität zu entwickeln [ 6 , 47 ]. Umgekehrt stellt das metabolische Syndrom einen Risikofaktor für das Auftreten einer Psoriasis dar [ 29 , 37 ]. Als Diagnosekriterien für ein metabolisches Syndrom gelten der Bauchumfang bei Männern von mehr als 94 cm und bei Frauen von mehr als 80 cm sowie das Vorliegen von mindestens 2 weiteren der folgenden Störungen: arterielle Hypertonie (systolisch ≥ 130 mm Hg, diastolisch ≥ 85 mm Hg als Mittelwert einer 24-h-Langzeitblutdruckmessung oder alternativ systolisch ≥ 140 mm Hg, diastolisch ≥ 90 mm Hg als wiederholte Einzelmessung) oder eine bereits behandelte arterielle Hypertonie, Nüchtern-Triglyzeride ≥ 150 mg/dl (≥ 1,7 mmol/l) (ohne Medikation), HDL-Cholesterin < 40 mg/dl (< 1,03 mmol/l) bei Männern und < 50 mg/dl (< 1,29 mmol/l) bei Frauen, erhöhte Nüchtern-Blutglukose ≥ 100 mg/dl (≥ 5,6 mmol/l) bzw.…”

Section: Metabolisches Syndromunclassified

Recommendations for individual comorbidity risk assessment in adult patients with psoriasis

Wohlrab

Körber²,

Adler

et al. 2023

Dermatologie

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ZusammenfassungEs ist seit Langem bekannt, dass chronisch entzündliche Systemerkrankungen wie die Psoriasis ein hohes Risiko für die Entwicklung von Komorbidität bieten. Im klinischen Alltag ist es deshalb von besonderer Bedeutung, Patient:innen zu identifizieren, die ein individuell erhöhtes Risikoprofil bieten. Bei Menschen mit Psoriasis konnten in epidemiologischen Studien in Abhängigkeit von Krankheitsdauer und -schwere die Komorbiditätsmuster „metabolisches Syndrom“, „kardiovaskuläre Komorbidität“ und „psychische Erkrankungen“ als besonders relevant identifiziert werden. In der alltäglichen Versorgung von Menschen mit Psoriasis in der dermatologischen Praxis haben sich der Einsatz einer interdisziplinär inhaltlich abgestimmten Checkliste für die Risikoanalyse und die Bahnung einer professionellen Anschlussversorgung bewährt. Auf der Basis einer existierenden Checkliste wurden die Inhalte von einer interdisziplinären Expertengruppe kritisch bewertet, und eine leitlinienorientierte Aktualisierung wurde vorgenommen. Der nun vorgelegte Analysebogen stellt nach Auffassung der Autoren ein praktikables, sachbezogen fokussiertes und inhaltlich aktualisiertes Werkzeug für die Risikoermittlung von Komorbidität bei Patient:innen mit mittelschwerer bis schwerer Psoriasis dar.

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Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study

Cited by 7 publications

References 40 publications

Positive association between different triglyceride glucose index-related indicators and psoriasis: evidence from NHANES

Positive association between different triglyceride glucose index-related indicators and psoriasis: evidence from NHANES

Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models

Recommendations for individual comorbidity risk assessment in adult patients with psoriasis

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