Changes in monoamine contents in the brains of Mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries.

Uchiyama-Tsuyuki, Yoshimi; Araki, Hiroaki; Karasawa, Yasuko; Aihara, Hironaka

doi:10.1254/jjp.50.357

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…In the present study, the striatal tissue contents of 3-MT in creased 0 and 5 min after reperfusion, and its extracellu lar level also did, as previously reported in other ischemic models (16,24). Thus, the excessive release of DA follow ing cerebral ischemia could be proved by not only the in crease in extracellular DA level but also the changes in the tissue contents of 3-MT.…”

Section: Discussionsupporting

confidence: 90%

“…On the contrary, the tissue contents of DA did not change markedly in the early period, name ly at 0 and 5 min after reperfusion, and slightly increased only at 240 min, while the tissue contents of NE and 5-HT decreased, or tended to decrease, both immediately after ischemia-reperfusion and during the subsequent period. Similar changes in tissue contents of monoamines, i.e., no change or increase in DA and decrease in 5-HT and NE, were reported in the striatum in several ischemic models (16)(17)(18)(19). A previous study (20) reported that the in vivo activity of tyrosine hydroxylase, but not trypto phan hydroxylase, was accelerated after ischemia-reperfu sion in anesthetized rats.…”

Section: Discussionsupporting

confidence: 70%

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Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia

Izumi

Inagaki

Kiuchi

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-We investigated the changes in striatal monoaminergic functions, focusing on the release and metabolism, in a cerebral ischemic model induced by a 5-min bilateral occlusion of the carotid arteries (BOCA) and reperfusion in anesthetized gerbils. In the microdialysis study, the striatal extracellular level of dopamine (DA) markedly increased (144-fold) immediately after BOCA. Although norepinephrine (NE) and 5-hydroxytryptamine (5-HT) could not be detected in the dialysates throughout the baseline period, they increased to detectable levels after BOCA. On the contrary, the tissue contents of NE and 5-HT decreas ed or tended to decrease up to 4 hr following reperfusion. Striatal DA contents did not show any changes in the early period after ischemia-reperfusion and slightly increased at 4 hr or later. Tissue contents of 3 methoxytyramine (3-MT), a metabolite of DA by catechol-O-methyltransferase (COMT), increased 0 and 5 min after reperfusion. Normethanephrine (NMN), which is a metabolite of NE by COMT, also increased not only 5 min after but also up to 4 hr after ischemia-reperfusion, indicating a sustained increase in NE re lease. These results suggested that the neuronal activity of NE, which is supposed to exert a protective effect on ischemic damage, was enhanced for a longer period than that of DA after transient ischemia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 70%

Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia

Izumi

Inagaki

Kiuchi

et al. 1993

Japanese Journal of Pharmacology

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“…In an experiment on transient ischemic attack using Mongolian gerbils, many transmitters are released during and immediately after transient ischemia (4). Although attention has been increasingly directed to the "delayed neuronal death in hippocampal CA1 neurons" elicited by transient ischemia, it is possible that functional deficit will occur after the carotid arteries occlusion.…”

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confidence: 99%

Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hyperactivity in Mongolian Gerbils

Araki

Yamamoto

Kobayashi

et al. 2002

Japanese Journal of Pharmacology

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ABSTRACT-Ischemia-induced hyperactivity is recognized several hours after both common carotid arteries' occlusion for 5 min in Mongolian gerbils, and it continues for at least 7 days. The aim of this study is to investigate the possible mechanisms of this abnormal behavior. Methamphetamine (MAP) (1 and 3 mg /kg) was administered for 7 days and imipramine (IMP) (5 and 10 mg /kg) was administered for 7 or 14 days. Bilateral carotid artery was occluded for 5 min 24 h after the last administrations of these drugs. MAP, which had been administered every day for 1 week, showed marked inhibition in the ischemia-induced hyperactivity. However, IMP did not have any effect even though it had been injected every day for 2 weeks. Hippocampal CA1 neuronal changes also appeared in the MAP-and IMP-administered groups. As the dopaminergic neurotransmission is facilitated by the repeated administration of MAP, the ischemia-induced hyperactivity may be related to abnormalities in dopaminergic function. The participation of the other neurotransmitters is also discussed.

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Changes in levels of monoamines and their metabolites in incompletely ischemic brains of spontaneously hypertensive rats

Kozuka¹,

Iwata²

1995

Neurochem Res

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In order to investigate changes in levels of monoamines and their related substances together with those of other neurotransmitters (acetylcholine and GABA), choline and substances related to energy metabolism (ATP, lactate and glucose) accompanying incomplete cerebral ischemia, a bilateral common carotid artery occlusion model of spontaneously hypertensive rats (SHR) was utilized. Animals were subjected to 1 or 2 h ischemia. Then the concentrations of substances were measured in the cerebral cortex, hippocampus and striatum and compared with control values. Due to the incomplete ischemia, ATP showed a moderate decrease, while lactate and choline increased remarkably, and GABA underwent a moderate increase. With regard to monoamines, both noradrenaline and serotonin levels were reduced in the cerebral cortex and hippocampus, whereas dopamine levels increased in the hippocampus. All monoamine metabolites, i.e. metabolites by monoamine oxidase (MAO), metabolites by catechol-O-methyltransferase (COMT), and metabolites by both MAO and COMT, underwent increases. The 3-methoxytyramine level in particular showed marked increases. Furthermore levels of precursor amino acids as well as 5-hydroxytryptophan rose. Acetylcholine decreased moderately only in the cerebral cortex. Among these changes, sustained increases in all the monoamine metabolites were characteristic of changes in the incompletely ischemic brain, suggesting that both COMT and MAO retain their activities in the incompletely ischemic brain.

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Changes in monoamine contents in the brains of Mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries.

Cited by 9 publications

References 16 publications

Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia

Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia

Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hyperactivity in Mongolian Gerbils

Changes in levels of monoamines and their metabolites in incompletely ischemic brains of spontaneously hypertensive rats

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