Changes in movement-related brain activity during transient deafferentation: a neuromagnetic study

Kristeva-Feige, Rumyana; Rossi, Símone; Pizzella, Vittorio; Sabato, Alessandro; Tecchio, Franca; Feige, Bernd; Romani, Gian Luca; Edrich, J.; Rossini, Paolo Maria

doi:10.1016/0006-8993(95)01537-x

Cited by 45 publications

(24 citation statements)

References 38 publications

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“…Activation resembling MEF was attributed to early somatosensory feedback (Cheyne and Weinberg, 1989;Kristeva et al, 1991). The role of MEF was elucidated in more detail in subsequent studies: anesthetic medial and radial nerve blockage during voluntary finger movements led to MEF increases suggesting that proprioceptive as well as cutaneous afferents contribute to the MEF (Kristeva-Feige et al, 1996). Enhancement via cortico-cortical afferents could also be an explanation of this result, since activation of somatosensory cells was found even 100 ms before muscle activation in monkeys during self paced movements (Soso and Fetz, 1980).…”

Section: Discussionmentioning

confidence: 89%

Increased sensory feedback in Tourette syndrome

et al. 2012

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Section: Discussionmentioning

confidence: 89%

Increased sensory feedback in Tourette syndrome

et al. 2012

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“…It has been demonstrated repeatedly that electro‐ and magnetoencephalographic source imaging is able to characterize the functional organization of the primary somatosensory cortex (e.g. Inui et al ., 2003; Beisteiner et al ., 2004), plastic changes after deafferentation/deefferentation (Mogilner et al ., 1993; Buchner et al ., 1995, 1999; Kristeva‐Feige et al ., 1996; Tinazzi et al ., 2003), after amputation (Elbert et al ., 1994, 1995, 1997; Yang et al ., 1994a,b; Flor et al ., 1995, 2001; Birbaumer et al ., 1997; Weiss et al ., 1998, 2000; Karl et al ., 2001), or as a consequence of special somatosensory skills (Elbert et al ., 1995; Sterr et al ., 1998a,b; Braun et al ., 2000, 2002). Different methods have been applied to assess plasticity using, for example, angles of cortical ‘mirror representations’ projected across the midline (Birbaumer et al ., 1997; Karl et al ., 2001), dipole strength (Elbert et al ., 1995), or distances between dipole locations for different stimulated parts of the body (Elbert et al ., 1994, 1995; Flor et al ., 1995, 2001; Weiss et al ., 1998, 2000).…”

Section: Methodsmentioning

confidence: 99%

Rapid functional plasticity in the primary somatomotor cortex and perceptual changes after nerve block

Weiß¹,

Miltner²,

Liepert³

et al. 2004

Eur J of Neuroscience

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The mature human primary somatosensory cortex displays a striking plastic capacity to reorganize itself in response to changes in sensory input. Following the elimination of afferent return, produced by either amputation, deafferentation by dorsal rhizotomy, or nerve block, there is a well-known but little-understood 'invasion' of the deafferented region of the brain by the cortical representation zones of still-intact portions of the brain adjacent to it. We report here that within an hour of abolishing sensation from the radial and medial three-quarters of the hand by pharmacological blockade of the radial and median nerves, magnetic source imaging showed that the cortical representation of the little finger and the skin beneath the lower lip, whose intact cortical representation zones are adjacent to the deafferented region, had moved closer together, presumably because of their expansion across the deafferented area. A paired-pulse transcranial magnetic stimulation procedure revealed a motor cortex disinhibition for two muscles supplied by the unaffected ulnar nerve. In addition, two notable perceptual changes were observed: increased two-point discrimination ability near the lip and mislocalization of touch of the intact ulnar portion of the fourth finger to the neighbouring third finger whose nerve supply was blocked. We suggest that disinhibition within the somatosensory system as a functional correlate for the known enlargement of cortical representation zones might account for not only the 'invasion' phenomenon, but also for the observed behavioural correlates of the nerve block.

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“…The second concerns the effects of transient deprivation of these signals, for example, in the case of amputation (Cohen et al 1991; Elbert et al 1994; Kew et al 1994), anesthesia (e.g. Rossini et al 1994; Rossini, Rossi, et al 1996; Rossini, Tecchio, et al 1996; Kristeva-Feige et al 1996; Rossi et al 1998), or immobilization (e.g. Liepert et al 1995; Huber et al 2006; Lissek et al 2009; Weibull et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Training the Motor Cortex by Observing the Actions of Others During Immobilization

et al. 2013

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Limb immobilization and nonuse are well-known causes of corticomotor depression. While physical training can drive the recovery from nonuse-dependent corticomotor effects, it remains unclear if it is possible to gain access to motor cortex in alternative ways, such as through motor imagery (MI) or action observation (AO). Transcranial magnetic stimulation was used to study the excitability of the hand left motor cortex in normal subjects immediately before and after 10 h of right arm immobilization. During immobilization, subjects were requested either to imagine to act with their constrained limb or to observe hand actions performed by other individuals. A third group of control subjects watched a nature documentary presented on a computer screen. Hand corticomotor maps and recruitment curves reliably showed that AO, but not MI, prevented the corticomotor depression induced by immobilization. Our results demonstrate the existence of a visuomotor mechanism in humans that links AO and execution which is able to effect cortical plasticity in a beneficial way. This facilitation was not related to the action simulation, because it was not induced by explicit MI.

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Changes in movement-related brain activity during transient deafferentation: a neuromagnetic study

Cited by 45 publications

References 38 publications

Increased sensory feedback in Tourette syndrome

Increased sensory feedback in Tourette syndrome

Rapid functional plasticity in the primary somatomotor cortex and perceptual changes after nerve block

Training the Motor Cortex by Observing the Actions of Others During Immobilization

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