“…Manual therapy interventions were used as part of a holistic approach to the patient and, therefore, combined treatment to structures locally as well as distant to the craniofacial region. Some studies have demonstrated that local as well as remote effects attributed to manual treatments, with changes in disability/functional parameters, [32][33][34]36 pain, [33][34][35]55 and changes related to neurophysiologic mechanisms of the autonomic nervous system. 26,27,29 , 56-58 The rhinosinusitis-specific questionnaires are used in the diagnosis and management of CRS, and patients in this study demonstrated a significant decrease in their SNAQ-11 and RSTF scores (Ps b .001) after their first treatment session.…”