Changes in Nervous System with Age

Wilcox, Harry H.

doi:10.2307/4589647

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…As people age, body organs, tissues, and cells undergo change. Histological studies have shown that ageing affects the central nervous system (CNS) since it experiences neuroanatomical alterations, including an overall reduction in brain activity [2,3]. Therefore, changes and damage in the CNS are worrisome, due to its decisive role in controlling and coordinating essential functions of the body, including cognitive functions [4].…”

Section: Introductionmentioning

confidence: 99%

Physical Activity Interventions and Their Effects on Cognitive Function in People with Dementia: A Systematic Review and Meta-Analysis

Cardona

Afi

Lakičević

et al. 2021

IJERPH

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Background: Physical activity (PA) has emerged as an alternative nonpharmacological approach to effectively address the effects of dementia. The primary aim was to identify and summarize PA interventions and their effects on cognitive function among persons with dementia (PwD). Methods: A systematic review was conducted with a meta-analysis using different electronic databases, such as PubMed, Embase, APA PsycNET, and the Web of Science. The identified and selected studies were randomized controlled trials (RCTs) that were written in English, published between 2000 and 2020, and implemented among PwD who received a PA intervention and whose cognitive function was measured at baseline and during a follow-up. Results: Twenty-two PA intervention studies met the eligibility criteria and showed a medium-size effect on the cognitive function of PwD, 0.4803 (95% CI = 0.1901–0.7704), with a high percentage of heterogeneity (I2 = 86%, p ≤ 0.0001). Moreover, this review complements other reviews by including eight studies that have not previously been considered. Overall, studies have methodological limitations. However, six studies implemented in the past five years have shown more robust methodological designs, including larger sample sizes and more comprehensive measurement tools. Conclusion: It is not yet possible to draw a conclusion on the ideal PA intervention for this population due to the high proportion of heterogeneity within the included studies. More emphasis is needed on the intensity of PA monitoring and adherence to such programs.

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Section: Introductionmentioning

confidence: 99%

Physical Activity Interventions and Their Effects on Cognitive Function in People with Dementia: A Systematic Review and Meta-Analysis

Cardona

Afi

Lakičević

et al. 2021

IJERPH

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“…The structural changes which occur in old age might be considered as normal ageing changes, whereas those occurring in the young are undoubtedly abnormal (Wilcox, 1956).…”

Section: Introductionmentioning

confidence: 99%

“…The anatomy of the nervous system is unique and highly specialized. The individual neurons in a single nucleus may be structurally and functionally different from those neurons of an adjacent nucleus (Wilcox, 1956). Neuroanatomy is one of the most research field during the past decades (Czeibert et al., 2014).…”

Section: Introductionmentioning

confidence: 99%

Age‐dependent changes in the brain of albino rats (Rattus norvegicus): A morphometric analysis and magnetic resonance imaging

Mohamad,

Hassan,

Moussa

et al. 2024

Anat Histol Embryol

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The current manuscript had been conducted to evaluate the effect of ageing on the brains of albino rats on the macro‐morphometric level and to assess the different parameters of brain and brain structures affected by ageing. Fifty apparently healthy rats of both sexes (27 males and 23 females) were used in the study, in addition to three rats for MRI. The animals were divided into four groups according to their age. Magnetic resonance imaging and cross sections of the brain were performed to document dimensions of various brain structures such as the hippocampus, surface area of lateral ventricle as well as dorsal and piriform cortices. Ageing would result into a negative impact on some brain structures. However, some others had not been affected as much. Furthermore, sex of the animal presented an important role as a variant where male rats of each age group demonstrated different results than their analogous female rats. In addition, MRI examination of the rat brain allowed recognition of the major cerebral structures. Findings of this work might be considered as a trial to provide a proof of changes resulted from normal ageing in both male and female rats and which sex is more affected than the other.

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“…These differences were progressively reduced as the ani mal increased in age. Wilcox (1956Wilcox ( , 1959 has suggested that the highly active cells tend to accumulate less pigment than the less active ones. He reported that the earliest pigmentation occurred in the mesencephalic nucleus of the trigeminal nerve, the activ ity of which was only slightly less than that of the somatic brachiomeric motor nuclei.…”

Section: Medial Defectsmentioning

confidence: 99%

Extrinsic and intrinsic blood supply and histomorphological changes associated with age in the cerebral arteries and brain nuclei in dog (Canis familiaris) and pig (Sus scrofa domestica)

Nanda

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Changes in Nervous System with Age

Cited by 7 publications

References 25 publications

Physical Activity Interventions and Their Effects on Cognitive Function in People with Dementia: A Systematic Review and Meta-Analysis

Physical Activity Interventions and Their Effects on Cognitive Function in People with Dementia: A Systematic Review and Meta-Analysis

Age‐dependent changes in the brain of albino rats (Rattus norvegicus): A morphometric analysis and magnetic resonance imaging

Extrinsic and intrinsic blood supply and histomorphological changes associated with age in the cerebral arteries and brain nuclei in dog (Canis familiaris) and pig (Sus scrofa domestica)

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